Changes in immune cell frequencies after cyclophosphamide or mycophenolate mofetil treatments in patients with systemic lupus erythematosus.

abstract：:Joint hypermobility syndrome (JHS) is common in patients presenting to rheumatologists and can cause a range of symptoms leading to physical and psychological distress. Chronic musculoskeletal pain in patients with JHS often responds poorly to analgesics, and a pain management approach may be helpful. Since patients w...

journal_title：Clinical rheumatology

authors： Rahman A,Daniel C,Grahame R

更新日期：2014-11-01 00:00:00

abstract：:Treatment with methotrexate (MTX) is well established in rheumatoid arthritis (RA), but dosing remains arbitrary as studies on the effect of different dosing schedules are lacking. In a randomised crossover design of 20 patients with RA, the effect of low (2.5mg) oral daily doses of MTX (15 mg weekly) was compared to ...

journal_title：Clinical rheumatology

authors： Seideman P

更新日期：1993-06-01 00:00:00

abstract：OBJECTIVE:This study was designed to compare outcomes of dose reduction, withdrawal, and continuation of tofacitinib in patients with rheumatoid arthritis (RA) and to examine effectiveness of rescue with an original treatment regimen for disease flare. METHODS:We prospectively enrolled 100 patients who had high or mod...

journal_title：Clinical rheumatology

authors： Mori S,Ueki Y

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVE:Tumor necrosis factor inhibitors (anti-TNF) have become the standard treatment for rheumatoid arthritis (RA). However, evidence is inconsistent as to whether RA patients with anti-TNF are associated with an increased risk of non-melanoma skin cancer (NMSC) compared with those without anti-TNF. We performed a ...

journal_title：Clinical rheumatology

authors： Wang JL,Yin WJ,Zhou LY,Zhou G,Liu K,Hu C,Zuo XC,Wang YF

更新日期：2020-03-01 00:00:00

abstract：:A 43-year-old man suffered from migrating then additive arthralgias associated with macroscopic and microscopic cutaneous lesions compatible at first sight with reticular erythematous mucinosis. After nine months, the cutaneous picture evolved into a papular mucinosis. The patient developed "multiple frozen joints" wi...

journal_title：Clinical rheumatology

authors： Dufour JP,Lachapelle JM,Nagant de Deuxchaisnes C,Devogelaer JP,Noel H,Maldague B

更新日期：1986-06-01 00:00:00

abstract：:Behçet's disease (BD) has well-defined pulmonary complications, but cardiopulmonary exercise testing and the strength of the respiratory muscles have not been studied in detail. We aimed to investigate the pulmonary functions tests, inspiratory and expiratory muscle strength and endurance, cardiopulmonary exercise tes...

journal_title：Clinical rheumatology

authors： Gökoğlu F,Yorgancioğlu ZR,Ustün N,Ardiç FA

更新日期：2007-09-01 00:00:00

abstract：:Mycophenolate mofetil (MMf) has recently been reported as a useful alternative immunosuppressive drug in autoimmune diseases. There is paucity of literature on its use in Takayasu's arteritis (TA). The aim of this study was to assess the safety and efficacy of MMf in Asian Indian patients with Takayasu's arteritis. Re...

journal_title：Clinical rheumatology

authors： Goel R,Danda D,Mathew J,Edwin N

更新日期：2010-03-01 00:00:00

abstract：:Perforin and granzyme A co-localize in the cytotoxic granules of killer cells like cytotoxic T lymphocytes (CTL). Perforin is the cytolytic pore-forming protein, whereas the function of the homodimeric serine protease granzyme A and other members of the granzyme family is still unclear. Granzyme A-immunoreactive cells...

journal_title：Clinical rheumatology

authors： Nordström DC,Konttinen YT,Sorsa T,Nykanen P,Pettersson T,Santavirta S,Tschopp J

更新日期：1992-12-01 00:00:00

abstract：:Although peripheral blood eosinophilia is observed in patients with active inflammatory rheumatoid arthritis (RA), RA is not a recognised cause of pulmonary eosinophilia. We describe a 55-year-old woman affected by chronic eosinophilic pneumonia (CEP) concomitantly with an initiation of RA. Both diseases responded rap...

journal_title：Clinical rheumatology

authors： Kwak JJ,Chang JE,Lee J,Cho YJ,Sung SH

更新日期：2003-09-01 00:00:00

abstract：:The coexistence of polymyositis (PM) and primary biliary cirrhosis (PBC) is rare; only nine cases have been described in English literature. We report a case of a 46-year-old woman presenting with these two autoimmune diseases. The diagnosis of PM was based on the symmetrical, proximal limb muscle weakness, elevated m...

journal_title：Clinical rheumatology

authors： Boki KA,Dourakis SP

更新日期：1995-05-01 00:00:00

abstract：:The aim of this study is to find out the outcome of 28 patients who got the diagnosis of primary fibromyalgia (pFM) 26 years ago. In 1986, 56 patients with widespread pain were examined and filled in a base questionnaire (BQ). Of them, 42 fulfilled the Yunus criteria for pFM. Twenty-six years later, addresses of 38 pa...

journal_title：Clinical rheumatology

authors： Isomeri R,Mikkelsson M,Partinen M,Kauppi MJ

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVE:MicroRNAs (miRNAs) regulate gene expression and are disease biomarkers. Rheumatoid arthritis (RA) patients have accelerated atherosclerosis leading to excess cardiovascular morbidity and mortality, but traditional risk factors for cardiovascular risk stratification are inadequate. In the general population, m...

journal_title：Clinical rheumatology

authors： Ormseth MJ,Solus JF,Sheng Q,Chen SC,Ye F,Wu Q,Oeser AM,Allen R,Raggi P,Vickers KC,Stein CM

更新日期：2021-01-02 00:00:00

abstract：:Takayasu arteritis (TA) is a chronic inflammatory disease. Interleukin (IL)-6 and IL-10 are important cytokines involved in the immune response of TA in some ethnicities. We investigated whether the single-nucleotide polymorphism (SNP) of IL-6 and IL-10 genes and their expressions were associated with TA in a Chinese ...

journal_title：Clinical rheumatology

authors： Gao Q,Lv N,Dang A,Li Z,Ye J,Zheng D

更新日期：2019-01-01 00:00:00

abstract：:Immunoglobulins are often high in active rheumatoid arthritis and fall when treatment with a slow-acting anti-rheumatic drug is instituted. We assessed the value of monitoring immunoglobulins during penicillamine therapy; 145 patients were followed for up to 5 years, IgA, IgM and IgG levels were compared to 12 other c...

journal_title：Clinical rheumatology

authors： Williams A,Scott DL,Greenwood A,Huskisson EC

更新日期：1988-09-01 00:00:00

abstract：:The immunoinflammatory pathogenesis of juvenile chronic arthritis (JCA) involves the activation of many pathways including various cytokines. We have evaluated the levels of interleukin(IL)-1, IL-6 and IL-8 in 29 JCA patients. The age range was 1-16 with a mean of 10.1. A disease activity score was developed on the ba...

journal_title：Clinical rheumatology

authors： Ozen S,Saatci U,Bakkaloglu A,Ozdemir O,Besbas N,Kirazli S,Ozdemir S

更新日期：1997-03-01 00:00:00

abstract：:Low-dose naltrexone (LDN) has been demonstrated to reduce symptom severity in conditions such as fibromyalgia, Crohn's disease, multiple sclerosis, and complex regional pain syndrome. We review the evidence that LDN may operate as a novel anti-inflammatory agent in the central nervous system, via action on microglial ...

journal_title：Clinical rheumatology

authors： Younger J,Parkitny L,McLain D

更新日期：2014-04-01 00:00:00

abstract：:The Revised Fibromyalgia Impact Questionnaire (FIQR) attempts to address the limitations of the Fibromyalgia Impact Questionnaire (FIQ). As there is no Turkish version of the FIQR available, we aimed to investigate the validity and reliability of a Turkish translation of the FIQR in Turkish female fibromyalgia (FM) pa...

journal_title：Clinical rheumatology

authors： Ediz L,Hiz O,Toprak M,Tekeoglu I,Ercan S

更新日期：2011-03-01 00:00:00

abstract：:Takayasu's arteritis (TA) is a rare vasculitis that affects the aorta and its primary branches. Heterogeneous clinical manifestations have been described in different geographical areas. We aimed to evaluate demographic, clinical, and angiographic features and the outcome in 16 TA patients who were followed in a singl...

journal_title：Clinical rheumatology

authors： Petrovic-Rackov L,Pejnovic N,Jevtic M,Damjanov N

更新日期：2009-02-01 00:00:00

abstract：:The aim of the study was to investigate the pulmonary parenchymal abnormalities by high resolution computed tomography (HRCT) in patients with various forms of scleroderma. Three scans were performed sequentially in all cases: one at the level of aortic arch, one at the tracheal carina and one 1-2 cm above the diaphra...

journal_title：Clinical rheumatology

authors： Dévényi K,Czirják L

更新日期：1995-11-01 00:00:00

abstract：:Monocytes are an important component in the innate immune system. However, studies to date have failed to conclude whether their levels are altered in patients with systemic lupus erythematosus (SLE). We applied the cytodiff counting method and comprehensively measured the circulating levels of distinct white blood ce...

journal_title：Clinical rheumatology

authors： Wu Z,Zhang S,Zhao L,Fei Y,Wang L,Li J,Wen X,Zeng X,Zhang F,Li Y

更新日期：2017-10-01 00:00:00

abstract：:The original version of this article was revised due to a retrospective Open Access order. ...

journal_title：Clinical rheumatology

authors： Gourlay ML,Gourlay LL

更新日期：2020-10-01 00:00:00

abstract：:Paroxysmal crises of fever and systemic inflammation herald familial Mediterranean fever (FMF), considered as the archetype of all inherited systemic autoinflammatory diseases. Inflammatory bouts are characterized by short-term and self-limited abdominal, thoracic, and/or articular symptoms which subside spontaneously...

journal_title：Clinical rheumatology

authors： Rigante D,Lopalco G,Tarantino G,Compagnone A,Fastiggi M,Cantarini L

更新日期：2015-09-01 00:00:00

abstract：:Survival and outcomes have improved considerably among patients with juvenile dermatomyositis (JDM) in the west. However, mortality continues to be high in the developing world. There is paucity of literature on this aspect of JDM from developing countries. We reviewed case files of all patients with JDM registered in...

journal_title：Clinical rheumatology

authors： Singh S,Suri D,Aulakh R,Gupta A,Rawat A,Kumar RM

更新日期：2014-11-01 00:00:00

abstract：:Juvenile systemic lupus erythematosus is a rare multisystemic autoimmune disease with variable clinical manifestations, and disease onset before 16 years of age. Patients younger than 5 years are rarely affected and the age of onset may contribute to the course of disease in terms of clinical presentation, organ invol...

journal_title：Clinical rheumatology

authors： Hedrich CM,Zappel H,Straub S,Laass MW,Wieczorek K,Hahn G,Heubner G,Gahr M

更新日期：2011-02-01 00:00:00

abstract：:While fibromyalgia is frequently associated with ear-related symptoms such as feeling of ear fullness, earache, and tinnitus, the pathogenesis of these ear-related symptoms in fibromyalgia patients is unknown. Here, we focused on clarifying the pathogenesis of ear fullness, a particularly common symptom observed in fi...

journal_title：Clinical rheumatology

authors： Iikuni F,Nomura Y,Goto F,Murakami M,Shigihara S,Ikeda M

更新日期：2013-10-01 00:00:00

abstract：:A 12-week double-blind randomized drug trial followed by an open extension period of 36 weeks was carried out in 38 male patients with ankylosing spondylitis (AS) to compare the efficacy and safety of diflunisal (500 mg twice daily) and phenylbutazone (200 mg twice daily). Both drugs proved to be effective in improvin...

journal_title：Clinical rheumatology

authors： Franssen MJ,Gribnau FW,van de Putte LB

更新日期：1986-06-01 00:00:00

abstract：:Over the last decade, biologic therapeutic proteins have advanced the treatment of diseases such as rheumatoid arthritis (RA). Therapeutic antibodies such as infliximab, adalimumab, rituximab, tocilizumab, golimumab, certolizumab pegol, the receptor construct etanercept, and abatacept, an anticluster of differentiatio...

journal_title：Clinical rheumatology

authors： Alawadhi A,Alawneh K,Alzahrani ZA

更新日期：2012-09-01 00:00:00

abstract：:The aim of this study was to identify and evaluate laboratory parameters associated with normal bone mineral density (BMD) and to test if -308 tumour necrosis factor (TNF) alpha gene promoter polymorphisms could influence BMD. We performed a comparative cross-sectional study of four main groups: young healthy individu...

journal_title：Clinical rheumatology

authors： Canhao H,Fonseca JE,Caetano-Lopes J,Saldanha C,Queiroz MV

更新日期：2008-03-01 00:00:00

abstract：OBJECTIVE:To explore the trends in diagnosis of Kawasaki disease (KD) and determine the characteristics for patients outside the usual age range of 6 months to 4 years. METHOD:A retrospective review of patients with KD identified in four epidemiological surveys spanning 20 years (1998-2017) in Shanghai was performed. ...

journal_title：Clinical rheumatology

authors： Zhao QM,Huang M,Huang MR,Chen S,Liu F,Huang GY,Shanghai Kawasaki Disease Research Group.

更新日期：2020-08-26 00:00:00

abstract：:We aimed to evaluate the presence of peripheral antineutrophil cytoplasmic antibodies (p-ANCA) and cytoplasmic antineutrophil cytoplasmic antibodies (c-ANCA) in children with SLE and to correlate its association of laboratory findings. Twenty-one children with SLE were studied. Serum samples in patients were tested by...

journal_title：Clinical rheumatology

authors： Bakkaloglu A,Topaloglu R,Saatçi U,Ozdemir S,Ozen S,Başsoy Y,Beşbaş N

更新日期：1998-01-01 00:00:00