Abstract:
:Perforin and granzyme A co-localize in the cytotoxic granules of killer cells like cytotoxic T lymphocytes (CTL). Perforin is the cytolytic pore-forming protein, whereas the function of the homodimeric serine protease granzyme A and other members of the granzyme family is still unclear. Granzyme A-immunoreactive cells formed 8 +/- 2% of the resting peripheral blood lymphocytes of healthy individuals. In contrast, granzyme A-positive cells formed 15% of peripheral blood mononuclear cells in patients with reactive or rheumatoid arthritis. However, 29 +/- 4% (p < 0.05 compared to normal peripheral blood) and 25 +/- 4% (p < 0.05) of all lymphocytes in synovial fluid in reactive and rheumatoid arthritis, respectively, were granzyme A-positive. This suggests involvement of cell-mediated cytolytic mechanisms in the articular pathogenic mechanisms. This involvement, however, does not differentiate between reactive and rheumatoid arthritis.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Nordström DC,Konttinen YT,Sorsa T,Nykanen P,Pettersson T,Santavirta S,Tschopp Jdoi
10.1007/BF02283113subject
Has Abstractpub_date
1992-12-01 00:00:00pages
529-32issue
4eissn
0770-3198issn
1434-9949journal_volume
11pub_type
杂志文章abstract::Paediatric systemic lupus erythematosus (pSLE) refers to childhood-onset systemic lupus erythematosus. pSLE has its own unique characteristics, and its pathogenesis is unclear. To study the relationship between microRNAs (miRNAs) and pSLE, we selected three pSLE patients who were newly diagnosed and had not yet been t...
journal_title:Clinical rheumatology
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doi:10.1007/s10067-014-2583-5
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journal_title:Clinical rheumatology
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pub_type: 杂志文章,评审
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更新日期:2018-03-01 00:00:00
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pub_type: 杂志文章,已发布勘误
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02031611
更新日期:1985-09-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02206665
更新日期:1991-12-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-019-04747-3
更新日期:2019-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s10067-014-2639-6
更新日期:2015-02-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-007-0691-1
更新日期:2008-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s10067-010-1496-1
更新日期:2010-09-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/BF02206850
更新日期:1987-09-01 00:00:00
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doi:10.1007/s10067-006-0255-9
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pub_type: 杂志文章
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s10067-007-0671-5
更新日期:2008-02-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2008-01-01 00:00:00
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pub_type: 杂志文章,已发布勘误
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更新日期:2019-06-01 00:00:00
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pub_type: 杂志文章
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