Granzyme A-immunoreactive cells in synovial fluid in reactive and rheumatoid arthritis.

Abstract:

:Perforin and granzyme A co-localize in the cytotoxic granules of killer cells like cytotoxic T lymphocytes (CTL). Perforin is the cytolytic pore-forming protein, whereas the function of the homodimeric serine protease granzyme A and other members of the granzyme family is still unclear. Granzyme A-immunoreactive cells formed 8 +/- 2% of the resting peripheral blood lymphocytes of healthy individuals. In contrast, granzyme A-positive cells formed 15% of peripheral blood mononuclear cells in patients with reactive or rheumatoid arthritis. However, 29 +/- 4% (p < 0.05 compared to normal peripheral blood) and 25 +/- 4% (p < 0.05) of all lymphocytes in synovial fluid in reactive and rheumatoid arthritis, respectively, were granzyme A-positive. This suggests involvement of cell-mediated cytolytic mechanisms in the articular pathogenic mechanisms. This involvement, however, does not differentiate between reactive and rheumatoid arthritis.

journal_name

Clin Rheumatol

journal_title

Clinical rheumatology

authors

Nordström DC,Konttinen YT,Sorsa T,Nykanen P,Pettersson T,Santavirta S,Tschopp J

doi

10.1007/BF02283113

subject

Has Abstract

pub_date

1992-12-01 00:00:00

pages

529-32

issue

4

eissn

0770-3198

issn

1434-9949

journal_volume

11

pub_type

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