Abstract:
:Psoriatic arthritis (PsA) is a chronic T cell-mediated inflammatory spondyloarthropathy affecting 10-40 % of psoriasis (PSO) patients (0.3-1.0 % of the general population). Recent epidemiological studies have shown an increased prevalence of cardiovascular (CV) risk factors and/or morbidity among PSO or PsA patients as compared to control individuals. The aim of this study is to describe the CV profile of PsA patients in Newfoundland, Canada. The possible impact of duration of chronic inflammation on CV variables was also explored. PsA patients were selected from a registry of PSO and PsA patients in Newfoundland. PsA patients diagnosed as per the CASPAR criteria are entered in the registry at the time of diagnosis, questioned on their medical history, and are followed indefinitely. Based on the duration since PsA diagnosis patients were classified as having early (<2 years) or established (≥2 years) PsA. CV risk was assessed using both conventional (hypertension, hypercholesterolemia, diabetes, obesity) and non-conventional (markers of chronic inflammation) factors. A total of 196 PsA patients were included; 42.9 % had early PsA and 57.1 % had established PsA. The prevalence of hypercholesterolemia, obesity, hypertension, diabetes mellitus, anxiety/depression, and coronary heart disease was 61.6, 59.7, 32.7, 13.8, 13.8, and 8.7 %, respectively. The prevalence of comorbidities was generally comparable between cohorts with exception of anxiety/depression, which was considerably higher in patients with established PsA compared to early PsA and obesity which was more common among male patients with established PsA. However, upon adjusting for age and gender differences, no statistically significant between-group differences were observed. Overall, these results suggest that PsA, even at early stages, is associated with significant CV comorbidity. These conditions should be taken into consideration when assessing the PsA burden of illness in epidemiological and health outcomes studies. Furthermore, early detection and management of these conditions could improve the patients' disability and quality of life.
journal_name
Clin Rheumatoljournal_title
Clinical rheumatologyauthors
Khraishi M,Aslanov R,Rampakakis E,Pollock C,Sampalis JSdoi
10.1007/s10067-014-2743-7subject
Has Abstractpub_date
2014-01-01 00:00:00pages
1495-500issue
10eissn
0770-3198issn
1434-9949journal_volume
33pub_type
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journal_title:Clinical rheumatology
pub_type: 杂志文章,评审
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journal_title:Clinical rheumatology
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pub_type: 杂志文章,评审
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journal_title:Clinical rheumatology
pub_type: 临床试验,杂志文章
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pub_type: 杂志文章,评审
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journal_title:Clinical rheumatology
pub_type: 杂志文章
doi:10.1007/s100670170028
更新日期:2001-01-01 00:00:00
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journal_title:Clinical rheumatology
pub_type: 临床试验,杂志文章
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journal_title:Clinical rheumatology
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journal_title:Clinical rheumatology
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pub_type: 杂志文章,已发布勘误
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journal_title:Clinical rheumatology
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journal_title:Clinical rheumatology
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journal_title:Clinical rheumatology
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