Humoral immunity to varicella zoster virus is altered in patients with rheumatoid arthritis.

Abstract:

INTRODUCTION:The prevalence of herpes zoster (HZ) is high in patients with rheumatologic diseases. The incidence in patients with rheumatoid arthritis (RA) is at least twice as high as in healthy people. Nevertheless, little is known about humoral immunity against varicella zoster virus (VZV), in particular in patients with RA. We, therefore, aimed to retrospectively compare VZV antibody concentrations in a collective of patients with RA in a German outpatient clinic with age- and sex-matched controls without RA. METHODS:We included n = 247 patients with RA from one single university centre as well as n = 250 age- and sex-matched controls from the in-house routine in this retrospective analysis. The concentration of VZV IgG antibody concentration was either available from the records or was measured using an enzyme-linked immunosorbent assay (ELISA). Additionally, avidity for specific IgG was analysed for some of the samples. The antibody concentrations have been compared between the two groups. Moreover, a consecutive subgroup analysis after stratification by age was performed. RESULTS:A total of 68.4% (n = 169) of the included patients were treated with conventional synthetic DMARDs, either as monotherapy or in combination. Biological originator DMARDs were used in 45.8% (n = 113) of the patients, with the majority (85%, n = 96) of them being on tumour necrosis factor (TNF)-inhibiting agents. As the main result of this study, antibody titres for VZV were found to be significantly lower in RA patients compared with healthy controls (p < 0.0001). The observed difference was most pronounced for the older patients being in the sixth and seventh decade. Antibody avidity was high in both groups with a significantly higher avidity among the controls (p = 0.0006). CONCLUSIONS:A possible explanation for the low VZV antibody concentration in RA patients might be premature immunosenescence, which most likely also effects the B cell compartment and humoral immunity. This thesis is emphasised by the significantly higher antibody avidity among the controls. The data also suggest that the increased HZ risk is a consequence of a poor humoral immunity. The available HZ vaccinations should contribute to decreasing the elevated HZ risk in RA patients. KEY POINTS:• Humoral immunity to varicella zoster virus seems to be reduced in patients with RA. • This impaired immunity might contribute to the increased herpes zoster susceptibility in RA patients. • An accelerated immunosenescence in RA could be causative for this finding.

journal_name

Clin Rheumatol

journal_title

Clinical rheumatology

authors

Krasselt M,Baerwald C,Liebert UG,Seifert O

doi

10.1007/s10067-019-04563-9

subject

Has Abstract

pub_date

2019-09-01 00:00:00

pages

2493-2500

issue

9

eissn

0770-3198

issn

1434-9949

pii

10.1007/s10067-019-04563-9

journal_volume

38

pub_type

杂志文章
  • Systemic lupus erythematosus presenting as catatonic schizophrenia.

    abstract::A patient fulfilling the diagnostic criteria for systemic lupus erythematosus and presenting with catatonic schizophrenia is described. Psychiatric features of the disease and their management are discussed. ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/BF02031619

    authors: Tishler M,Abramov AL

    更新日期:1985-09-01 00:00:00

  • Granzyme A-immunoreactive cells in synovial fluid in reactive and rheumatoid arthritis.

    abstract::Perforin and granzyme A co-localize in the cytotoxic granules of killer cells like cytotoxic T lymphocytes (CTL). Perforin is the cytolytic pore-forming protein, whereas the function of the homodimeric serine protease granzyme A and other members of the granzyme family is still unclear. Granzyme A-immunoreactive cells...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/BF02283113

    authors: Nordström DC,Konttinen YT,Sorsa T,Nykanen P,Pettersson T,Santavirta S,Tschopp J

    更新日期:1992-12-01 00:00:00

  • Comparison of three classification criteria of rheumatoid arthritis in an inception early arthritis cohort.

    abstract::The aim of this study is to compare the three classification criteria for rheumatoid arthritis (RA) in a large cohort of early arthritis patients. Patients who had at least one clinically swollen joint with disease duration no more than 1 year and age more than 18 years were enrolled. The clinical and laboratory param...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-016-3281-2

    authors: Ye H,Su Y,Li R,Zhao J,Liu X,Mei Y,Zhang Z,Guo J,Bi L,Liu X,Wang G,Liu J,Leng X,Gu F,Sun L,Zou Q,Fang Y,Jiang Q,Li Z

    更新日期:2016-10-01 00:00:00

  • Differences in clinical Pneumocystis pneumonia in rheumatoid arthritis and other connective tissue diseases suggesting a rheumatoid-specific interstitial lung injury spectrum.

    abstract::To compare Pneumocystis pneumonia (PCP) in patients with rheumatoid arthritis (RA) with PCP in patients with non-RA connective tissue diseases (CTDs) in order to clarify the characteristics of the former. We extracted consecutive patients satisfying the following criteria for "clinical PCP": (1) positive plasma β-D-gl...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-018-4157-4

    authors: Shimada K,Yokosuka K,Nunokawa T,Sugii S

    更新日期:2018-08-01 00:00:00

  • Treatment of therapy-resistant sarcoidosis with adalimumab.

    abstract::A possible role of tumor necrosis factor alpha (TNFalpha) in the pathomechanism of sarcoidosis must be considered in the analysis of this disorder since elevated concentrations of this cytokine have been found. In addition, TNFalpha expression could be demonstrated in sarcoid granulomata [1]. It is well known that TNF...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-005-0037-9

    authors: Callejas-Rubio JL,Ortego-Centeno N,Lopez-Perez L,Benticuaga MN

    更新日期:2006-07-01 00:00:00

  • Central nervous system involvement in patients with antineutrophil cytoplasmic antibody-associated vasculitis: a study of 29 cases in a single Chinese center.

    abstract:BACKGROUND:In antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), central nervous system (CNS) involvement is relatively uncommon. The current study retrospectively investigated the clinical features and outcomes of AAV patients with CNS involvement. METHODS:A total of 497 AAV patients were retrosp...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-020-04975-y

    authors: Ma TT,Li ZY,Geng YS,Chen M,Zhao MH

    更新日期:2020-07-01 00:00:00

  • Increased IL-6 expression on THP-1 by IL-34 stimulation up-regulated rheumatoid arthritis Th17 cells.

    abstract::IL-34 is a pleiotropic cytokine, which is a key regulator of monocytes/macrophages and might participate in the pathogenesis of RA. In this study, we aimed to explore the effect of IL-34 on the monocyte-like cell line THP-1 and the quantitative variation of Th17 cells in THP-1 and RA CD4+T cells coculture system. CD4+...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-017-3746-y

    authors: Wang B,Tang Y,Sun X,Ouyang X,Li H,Wei J,Zhang Y,Li X

    更新日期:2018-01-01 00:00:00

  • Pattern of systemic lupus erythematosus among Nigerians.

    abstract::Systemic lupus erythematosus (SLE) has rarely being reported among African Blacks, in contrast with African-Americans. Such reports have been mostly case reports. Our encounter with new cases shows that this disease may not be rare after all. The objective of this study was to study the clinical presentations, laborat...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-009-1139-6

    authors: Adelowo OO,Oguntona SA

    更新日期:2009-06-01 00:00:00

  • CMV enteritis causing ileal perforation in underlying lupus enteritis.

    abstract::We report a case of cytomegalovirus (CMV) enteritis in a 31 year-old -woman with lupus enteritis. In August 2002 the patient complained of severe abdominal pain. An abdominopelvic CT scan at the time showed free air in the peritoneal cavity and wall thickening of the ileal loop. She was diagnosed as having panperitoni...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-003-0825-z

    authors: Bang S,Park YB,Kang BS,Park MC,Hwang MH,Kim HK,Lee SK

    更新日期:2004-02-01 00:00:00

  • Early onset systemic lupus erythematosus: differential diagnoses, clinical presentation, and treatment options.

    abstract::Juvenile systemic lupus erythematosus is a rare multisystemic autoimmune disease with variable clinical manifestations, and disease onset before 16 years of age. Patients younger than 5 years are rarely affected and the age of onset may contribute to the course of disease in terms of clinical presentation, organ invol...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,评审

    doi:10.1007/s10067-010-1576-2

    authors: Hedrich CM,Zappel H,Straub S,Laass MW,Wieczorek K,Hahn G,Heubner G,Gahr M

    更新日期:2011-02-01 00:00:00

  • Treatment of fibromyalgia (fibrositis syndrome): a parallel double blind trial with carisoprodol, paracetamol and caffeine (Somadril comp) versus placebo.

    abstract::Forty-three of fifty-eight (74.1%) female patients with fibromyalgia completed an eight-week treatment period testing the combination of carisoprodol, paracetamol (acetaminophen) and caffeine versus placebo. Twenty-three patients received placebo and twenty active medication. In the placebo group 56.5% of the patients...

    journal_title:Clinical rheumatology

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF02030081

    authors: Vaerøy H,Abrahamsen A,Førre O,Kåss E

    更新日期:1989-06-01 00:00:00

  • Clinical characteristics and treatment outcomes of patients with relapsing polychondritis with airway involvement.

    abstract::We investigated the clinical characteristics, management modalities, and outcomes in patients with relapsing polychondritis (RP) with airway involvement. The medical records of RP patients with airway involvement seen at Samsung Medical Center from August 2004 to December 2011 were collected. The clinical manifestatio...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-013-2279-2

    authors: Hong G,Kim H

    更新日期:2013-09-01 00:00:00

  • Does rural residence impact total ankle arthroplasty utilization and outcomes?

    abstract::The objective of this study was to compare total ankle arthroplasty (TAA) utilization and outcomes by patient residence. We used the Nationwide Inpatient Sample (NIS) from 2003 to 2011 to compare utilization and outcomes (post-arthroplasty discharge disposition, length of hospitalization, and mortality) by rural vs. u...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-015-2908-z

    authors: Singh JA,Ramachandaran R

    更新日期:2016-02-01 00:00:00

  • Interleukin-1, -6, and -8 levels in juvenile chronic arthritis.

    abstract::The immunoinflammatory pathogenesis of juvenile chronic arthritis (JCA) involves the activation of many pathways including various cytokines. We have evaluated the levels of interleukin(IL)-1, IL-6 and IL-8 in 29 JCA patients. The age range was 1-16 with a mean of 10.1. A disease activity score was developed on the ba...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/BF02247847

    authors: Ozen S,Saatci U,Bakkaloglu A,Ozdemir O,Besbas N,Kirazli S,Ozdemir S

    更新日期:1997-03-01 00:00:00

  • Intravenous cyclophosphamide pulse therapy for the treatment of lung disease associated with scleroderma.

    abstract::Until recently, renal crisis was the most significant cause of morbidity and mortality in patients with scleroderma (SSc). Nowadays, following the introduction of angiotensin-converting enzyme inhibitors used in renovascular hypertension, pulmonary fibrosis and pulmonary hypertension have become the most common causes...

    journal_title:Clinical rheumatology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s100670050138

    authors: Davas EM,Peppas C,Maragou M,Alvanou E,Hondros D,Dantis PC

    更新日期:1999-01-01 00:00:00

  • Very recent onset arthritis: the value of initial rheumatologist evaluation and anti-cyclic citrullinated peptide antibodies in the diagnosis of rheumatoid arthritis.

    abstract::The objective of this study is to identify baseline factors associated with rheumatoid arthritis (RA) diagnosis at the end of 1-year follow-up in a cohort of patients with very recent onset arthritis. Incident cases with self-reported arthritis (

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-009-1206-z

    authors: Rojas-Serrano J,Burgos-Vargas R,Pérez LL,García CG,Moctezuma F,Vázquez-Mellado J

    更新日期:2009-10-01 00:00:00

  • Spontaneous fracture of the sternum simulating myocardial infarction.

    abstract::Spontaneous fractures of the sternum are rare but worth knowing as they may simulate acute cardiac and pulmonary emergencies. A case of an insufficiency sternal fracture mimicking myocardial infarction and subsequent anginal pain is presented. The risk factors of this condition, its clinical features and the diagnosti...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/BF02207687

    authors: Schapira D,Nachtigal A,Scharf Y

    更新日期:1995-07-01 00:00:00

  • Urticaria as a presenting manifestation of adult-onset Still's disease.

    abstract::Adult-onset Still's disease (AOSD) is a rare disorder of unknown aetiology, characterised by high spiking fever, an evanescent, erythematous, maculopapular rash, arthralgia or arthritis, lymphadenopathy, hepatosplenomegaly, sore throat and serositis. It is associated with marked leukocytosis, high erythrocyte sediment...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s100670070034

    authors: Salaffi F,Filosa G,Bugatti L,Maestrini MD

    更新日期:2000-01-01 00:00:00

  • Uric acid metabolism in two patients with coexistent Down's syndrome and gout.

    abstract::Two patients with coexistent Down's syndrome and gout are described. Although increased serum urate levels are frequently reported in Down's syndrome, only a few such patients have been described with concomitant gout. In our patients no significant alterations of the purine salvage pathway were found, and the turnove...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/BF02030760

    authors: Ciompi ML,Bazzichi LM,Bertolucci D,Mazzoni MR,Barbieri P,Mencacci S,Macchia D,Mariani G

    更新日期:1984-06-01 00:00:00

  • Clinical characteristics of autoimmune rheumatic disease-related organizing pneumonia.

    abstract::To study the clinical characteristics of autoimmune rheumatic disease-related organizing pneumonia (AIRD-OP), the clinical presentation, radiological findings, treatment, and outcome of AIRD-OP patients were analyzed, in comparison with patients with cryptogenic organizing pneumonia (COP). A total of 131 OP patients w...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-017-3694-6

    authors: Dong X,Zheng Y,Wang L,Chen WH,Zhang YG,Fu Q

    更新日期:2018-04-01 00:00:00

  • Gout: a disease involved with complicated immunoinflammatory responses: a narrative review.

    abstract::Gout is a disease with acute and/or chronic inflammation and tissue damage induced by the precipitation of monosodium urate crystal (MSU) crystals in bone joints, kidneys, and subcutaneous sites. In recent years, with the continuous research on gout animal models and patient clinical investigations, the mechanism of i...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,评审

    doi:10.1007/s10067-020-05090-8

    authors: Wu M,Tian Y,Wang Q,Guo C

    更新日期:2020-10-01 00:00:00

  • Gynaecologic history in systemic sclerosis.

    abstract::The aim of the study was to analyse the gynaecologic history of 150 Brazilian patients with systemic sclerosis (SSc) by comparing the outcome of the pregnancies before and after disease onset and in the two clinical variants of SSc, as well as to assess the effects of the pregnancy on the progress of the disease. A re...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s100670050152

    authors: Sampaio-Barros PD,Samara AM,Marques Neto JF

    更新日期:2000-01-01 00:00:00

  • Axial spondyloarthritis: the heart of the matter.

    abstract::A variety of cardiovascular clinical manifestations have been described in patients with spondyloarthritis, especially in well-established ankylosing spondylitis. These include both structural heart disease, conduction defects and ischemic heart disease. The true prevalence of cardiovascular involvement in patients wi...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,评审

    doi:10.1007/s10067-015-2959-1

    authors: Gensler LS

    更新日期:2015-06-01 00:00:00

  • Predicting outcomes in rheumatoid arthritis.

    abstract::Biologic therapies have brought improved efficacy in the field of rheumatoid arthritis (RA), but their use in clinical practice may be limited by concerns over cost. Predictive models are, therefore, needed to identify those people with RA with the worst potential outcomes, who will benefit most from the use of these ...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章,评审

    doi:10.1007/s10067-010-1639-4

    authors: Conaghan PG

    更新日期:2011-03-01 00:00:00

  • Anti-CCP antibodies have more diagnostic impact than rheumatoid factor (RF) in a population tested for RF.

    abstract::To compare the diagnostic powers of rheumatoid factor (RF) and anti-cyclic citrullinated peptide (CCP) in a population selected for its high statistical relevance, over a 6-month period, an informed consent to test for anti-CCP was obtained from 1,025 consecutive patients for whom RF was ordered at a University labora...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-007-0601-6

    authors: Silveira IG,Burlingame RW,von Mühlen CA,Bender AL,Staub HL

    更新日期:2007-11-01 00:00:00

  • Efficacy of methylprednisolone pulse therapy in children with rheumatoid arthritis.

    abstract::Pulse therapy is one of the most well-known methods used in the treatment of juvenile rheumatoid arthritis. This study assessed the outcome of methylprednisolone pulse therapy, its rate of efficacy, and its associated complications in patients with juvenile rheumatoid arthritis (JRA). This cross-sectional study was pe...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-008-0919-8

    authors: Aghighi Y,Attarod L,Javanmard M

    更新日期:2008-11-01 00:00:00

  • Serum levels of the bone turnover markers dickkopf-1, osteoprotegerin, and TNF-α in knee osteoarthritis patients.

    abstract::Knee osteoarthritis (KOA) is a common degenerative joint disease causing pain, stiffness, reduced motion, swelling, crepitus, and disability. Several inflammatory markers and cartilage degradation products can be used as biomarkers in OA. The key factors of bone metabolism in normal joint bone, dickkopf-1 (DKK1) and o...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-017-3690-x

    authors: Min S,Wang C,Lu W,Xu Z,Shi D,Chen D,Teng H,Jiang Q

    更新日期:2017-10-01 00:00:00

  • A survey of renal function in outpatients with rheumatoid arthritis.

    abstract::The acute renal side-effects of nonsteroidal anti-inflammatory drugs are well documented. These include interstitial nephritis, hyperkalaemia, renal tubular acidosis, fluid retention, hypertension and nephrotic syndrome. The long-term effects are less well known. We have carried out a cross-sectional survey of an unse...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/BF02204466

    authors: Richards IM,Fraser SM,Capell HA,Fox JG,Boulton-Jones JM

    更新日期:1988-06-01 00:00:00

  • An early diagnosis of kidney involvement in immunologically-mediated multisystem diseases.

    abstract::Kidney involvement in immuno-mediated diseases is a life threatening complication to be early detected. Glomerulo-tubular functional indices, kidney-released enzymes and metabolic profiles were assessed in 21 patients with systemic lupus erythematosus, progressive systemic sclerosis and mixed cryoglobulinaemia, withou...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/BF02231679

    authors: Matteucci E,Migliorini P,Bertoni C,Dolcher MP,Marchini B,Giampietro O

    更新日期:1996-01-01 00:00:00

  • High-dose methylprednisolone pulse therapy upregulated FcγRIIb expression on B cells in primary Sjögren's syndrome patients with thrombocytopenia.

    abstract::Abnormalities in B cell are characteristic feature of primary Sjögren's syndrome (pSS). As FcγRIIb is a key regulator of B cells, the objective of this study is to investigate the role of the inhibitory receptor FcγRIIb in B cells from pSS patients, and whether glucocorticoid can affect B cell subpopulations or FcγRII...

    journal_title:Clinical rheumatology

    pub_type: 杂志文章

    doi:10.1007/s10067-013-2344-x

    authors: Chen H,Zhou S,Su D,Lu L,Li X,Sun L

    更新日期:2013-12-01 00:00:00