Abstract:
OBJECTIVES:To explore the anxiolytic effects of a 4-month randomized, placebo-controlled trial of exercise and antidepressant medication in patients with major depressive disorder (MDD), and to examine the potential modifying effects of anxiety in treating depressive symptoms. MATERIALS AND METHODS:In this secondary analysis of the SMILE-II trial, 148 sedentary adults with MDD were randomized to: (a) supervised exercise, (b) home-based exercise, (c) sertraline, or (d) placebo control. Symptoms of state anxiety measured by the Spielberger Anxiety Inventory were examined before and after 4 months of treatment. Depressive symptoms were assessed by the Hamilton Depression Rating Scale (HAMD) and Beck Depression Inventory-II (BDI-II). Analyses were carried out using general linear models. RESULTS:Compared to placebo controls, the exercise and sertraline groups had lower state anxiety scores (standardized difference = 0.3 [95% CI = -0.6, -0.04]; p = 0.02) after treatment. Higher pretreatment state anxiety was associated with poorer depression outcomes in the active treatments compared to placebo controls for both the HAMD (p = .004) and BDI-II (p = .02). CONCLUSION:Aerobic exercise as well as sertraline reduced symptoms of state anxiety in patients with MDD. Higher levels of pretreatment anxiety attenuated the effects of the interventions on depressive symptoms, however, especially among exercisers. Patients with MDD with higher comorbid state anxiety appear to be less likely to benefit from exercise interventions in reducing depression and thus may require supplemental treatment with special attention to anxiety.
journal_name
Depress Anxietyjournal_title
Depression and anxietyauthors
Blumenthal JA,Babyak MA,Craighead WE,Davidson J,Hinderliter A,Hoffman B,Doraiswamy PM,Sherwood Adoi
10.1002/da.23088subject
Has Abstractpub_date
2020-08-12 00:00:00eissn
1091-4269issn
1520-6394pub_type
杂志文章abstract:BACKGROUND:There has been little research on the generalizability of clinical trials for generalized anxiety disorder (GAD). The present study examines the generalizability of pharmacological and psychotherapy clinical trials' results of individuals with DSM-IV GAD to a large community sample. METHODS:Data were drawn ...
journal_title:Depression and anxiety
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abstract::Given the high rates of maladjustment among children of depressed mothers, parenting is likely to cause significant life stress in this population, potentially worsening the course of mothers' depression. The present study is a comparison of severe life stress in 38 mothers and 62 non-mothers receiving treatment for r...
journal_title:Depression and anxiety
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abstract::Disrupted sensory filtering, or problems with suppressing irrelevant environmental sensory stimuli, has been reported in individuals with posttraumatic stress disorder (PTSD). However, the relationship of sensory filtering deficits to specific PTSD symptoms versus an association with general trauma exposure is unclear...
journal_title:Depression and anxiety
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journal_title:Depression and anxiety
pub_type: 杂志文章,评审
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abstract:BACKGROUND:Complicated grief (CG) is a bereavement-specific syndrome distinct from but commonly comorbid with posttraumatic stress disorder (PTSD). While bereavement is common among military personnel (Simon et al., 2018), there is little research on the impact of CG comorbidity on PTSD treatment outcomes. METHODS:To ...
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pub_type: 杂志文章,随机对照试验
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20027
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Depression and anxiety
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doi:
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Depression and anxiety
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doi:10.1002/da.22379
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journal_title:Depression and anxiety
pub_type: 杂志文章
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journal_title:Depression and anxiety
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journal_title:Depression and anxiety
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doi:
更新日期:1997-01-01 00:00:00
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pub_type: 杂志文章
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abstract::This study explores the psychometric properties of the Portuguese version of Corah's Dental Anxiety Scale (DAS), an instrument designed to assess the manifestations of dental anxiety. The DAS has been translated into several languages, but no adaptation and reliability analysis of the Portuguese version of the scale h...
journal_title:Depression and anxiety
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abstract::Little is known about the beliefs of patients suffering from major depression as to the causes of their illness and effective treatments. This study introduces a new instrument for capturing these beliefs, the Explanatory Model for Depression (EMD) Questionnaire, and explores the beliefs of patients participating in a...
journal_title:Depression and anxiety
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journal_title:Depression and anxiety
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