当前位置： SCI文献检索 > JOURNAL OF PSYCHIATRIC RESEARCH期刊下所有文献 > Altered T2* relaxation time of the hippocampus in major depressive disorder: implications of ultra-high field magnetic resonance imaging.

Altered T2* relaxation time of the hippocampus in major depressive disorder: implications of ultra-high field magnetic resonance imaging.

Abstract：

:Previous studies with 1.5 T or 3.0 T magnetic resonance imaging (MRI) have produced mixed results regarding the structural changes of the hippocampus in major depressive disorder (MDD). Subtle region-specific hippocampal tissue changes might be more sensitively detected by measuring the T2* relaxation time (T2*-RT) by ultra-high-field (UHF) MRI, as it provides much higher contrast and sensitivity and consequently greater resolution. We assessed the T2*-RTs of hippocampal sub-regions in 16 MDD patients (9 with recurrent MDD) and 16 control subjects using an UHF 7.0 T MRI system. T2*-RTs of CA1, CA2, CA3, CA4, and subiculum were calculated for both left and right hippocampus. MDD patients had significantly longer T2*-RTs in the right CA1 and subiculum than control subjects. Patients with recurrent MDD had significantly longer T2*-RTs in the right subiculum than those experiencing a first depressive episode, and longer T2*-RTs in the right CA1, CA3, and subiculum than control subjects. Values for T2*-RTs of the right CA3 were significantly correlated with illness duration. In conclusion, we report that T2*-RTs in the right subiculum and CA1 were increased in patients with MDD, especially in cases of recurrent MDD. These findings suggest that region-specific hippocampal damage may be occurring in recurrent depression.

journal_name

J Psychiatr Res

journal_title

Journal of psychiatric research

authors

Cho ZH,Kim YB,Han JY,Kim NB,Hwang SI,Kim SJ,Cho SJ

doi

10.1016/j.jpsychires.2010.02.014

subject

Has Abstract

pub_date

2010-10-01 00:00:00

pages

881-6

issue

14

eissn

0022-3956

issn

1879-1379

pii

S0022-3956(10)00055-5

journal_volume

44

pub_type

杂志文章

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