Abstract:
:For over a century, clinicians have struggled with how to conceptualize the primary psychoses, which include psychotic mood disorders and schizophrenia. Indeed, the nature of the relationship between mood disorders and schizophrenia is an area of ongoing controversy. Psychotic bipolar disorders have characteristics such as phenomenology, biology, therapeutic response, and brain imaging findings, suggesting both commonalities with and dissociations from schizophrenia. Taken together, these characteristics are in some instances most consistent with a dimensional view, with psychotic bipolar disorders being intermediate between non-psychotic bipolar disorders and schizophrenia spectrum disorders. However, in other instances, a categorical approach appears useful. Although more research is clearly necessary to address the dimensional versus categorical controversy, it is feasible that at least in the interim, a mixed dimensional/categorical approach could provide additional insights into pathophysiology and management options, which would not be available utilizing only one of these models.
journal_name
J Psychiatr Resjournal_title
Journal of psychiatric researchauthors
Ketter TA,Wang PW,Becker OV,Nowakowska C,Yang Ysdoi
10.1016/s0022-3956(03)00099-2subject
Has Abstractpub_date
2004-01-01 00:00:00pages
47-61issue
1eissn
0022-3956issn
1879-1379pii
S0022395603000992journal_volume
38pub_type
杂志文章,评审abstract::The heterogeneity of mood and anxiety disorders has been widely documented and epidemiologic studies have found different prevalence rates for psychiatric disorders across subgroups (i.e. sex and race/ethnic). The current study compares the latent class structure across sex and race/ethnic groups to determine group di...
journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2018.07.005
更新日期:2018-09-01 00:00:00
abstract::Brain-derived neurotrophic factor (BDNF) plays a central role in synaptic plasticity and neurogenesis. Bipolar disorder (BD) is among the most disabling of all psychiatric disorders and is associated with poor outcomes. Some studies suggest that BDNF levels decrease during mood states and remain normal during euthymia...
journal_title:Journal of psychiatric research
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.jpsychires.2011.03.002
更新日期:2011-08-01 00:00:00
abstract::Attention-deficit and hyperactivity disorder (ADHD) is a common psychiatric disorder with a worldwide prevalence of 5-6% in children and 4.4% in adults. Recently, copy number variations (CNVs) have been implicated in different neurodevelopmental disorders such as ADHD. Based on these previous reports that focused on p...
journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2013.10.022
更新日期:2014-02-01 00:00:00
abstract::Smooth pursuit eye movement (SPEM) performance has been linked to nonvoluntary attentional processes. Amphetamine is a psychotropic drug with documented effects on attentional performance. In order to evaluate the relationship between SPEM performance and amphetamine's attentional effects, SPEM performance was measure...
journal_title:Journal of psychiatric research
pub_type: 临床试验,杂志文章
doi:10.1016/0022-3956(87)90013-6
更新日期:1987-01-01 00:00:00
abstract::The neurogenesis hypothesis of major depression has two main facets. One states that the illness results from decreased neurogenesis while the other claims that the very functioning of antidepressants depends on increased neurogenesis. In order to verify the latter, we have used cyclin D2 knockout mice (cD2 KO mice), ...
journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2014.05.009
更新日期:2014-09-01 00:00:00
abstract:OBJECTIVES:A vast amount of studies demonstrates the presence of psychomotor slowing in schizophrenia. The objective of the present study was to investigate whether this overall psychomotor slowing can be divided into distinct processes that differentially affect cognitive functioning in schizophrenia. METHODS:The pen...
journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2005.04.014
更新日期:2006-04-01 00:00:00
abstract::The concentrations of amino acids in the cerebrospinal fluid (CSF) were measured in pairs of healthy mono- and dizygotic twins. Intraclass correlations were calculated. Genetic and cultural heritabilities were estimated using a path analytical model. CSF levels of glycine, tyrosine and arginine were shown to be influe...
journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/0022-3956(88)90028-3
更新日期:1988-01-01 00:00:00
abstract:INTRODUCTION:It has been proposed that the often found hyperintensities on MRI representing vascular changes might be correlated with a worse outcome of cognitive malfunction in depression. The purpose of this study was to evaluate neuropsychological status in the acute depressed state and following remission and to in...
journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2004.06.004
更新日期:2005-03-01 00:00:00
abstract::It is generally accepted that patients with major depressive disorder have smaller hippocampus size compared to healthy people. However, it is still not known if this situation exists before the onset of the disease or is a result of the toxic mechanism created by the depression itself. The findings of the long-term f...
journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2012.08.022
更新日期:2013-01-01 00:00:00
abstract::Temperamental features are strongly associated with suicidal behaviors both in general population and clinical samples. In the present study we considered the association between personality traits, measured by Temperament and Character Inventory (TCI), and suicidal behavior. We analyzed five samples: a German control...
journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2007.10.006
更新日期:2008-09-01 00:00:00
abstract:BACKGROUND:Although schizophrenia and major depressive disorder (MDD) differ on a variety of neuroanatomical measures, a diagnostic tool to discriminate these disorders has not yet been established. We tried to identify structural changes of the brain that best discriminate between schizophrenia and MDD on the basis of...
journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2013.06.010
更新日期:2013-10-01 00:00:00
abstract::Self-harm behaviors are a major public health concern across the lifespan, particularly among individuals with psychiatric disorders. Little research, however, has examined these behaviors among individuals with a diagnosis characterized by recurrent acts of impulsive aggression, Intermittent Explosive Disorder (IED)....
journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2014.08.013
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Resilience, the ability to adapt positively to adversity, may be an important factor in successful aging. However, the assessment and correlates of resilience in elderly individuals have not received adequate attention. METHOD:A total of 1395 community-dwelling women over age 60 who were participants at the...
journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2008.03.007
更新日期:2008-12-01 00:00:00
abstract::Efficacy trials with antidepressant drugs often fail to show significant treatment effect even though efficacious treatments are investigated. This failure can, amongst other factors, be attributed to the lack of sensitivity of the statistical method as well as of the endpoints to pharmacological activity. For regulat...
journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2007.11.009
更新日期:2008-10-01 00:00:00
abstract::Twenty-six psychoneurotic inpatients received oxazepam (60-120 mg daily) or placebo for one to two weeks. The strongest evidence for the superiority of oxazepam over placebo was that a greater proportion of oxazepam-treated patients remained on the study the full two weeks than placebo-treated patients. Patients' self...
journal_title:Journal of psychiatric research
pub_type: 杂志文章,随机对照试验
doi:10.1016/0022-3956(66)90007-0
更新日期:1966-12-01 00:00:00
abstract::A childhood history of attention deficit hyperactivity disorder (ADHD) is common in psychotic disorders, yet prescription stimulants may interact adversely with the physiology of these disorders. Specifically, exposure to stimulants leads to long-term increases in dopamine release. We therefore hypothesized that indiv...
journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2015.09.012
更新日期:2015-12-01 00:00:00
abstract:OBJECTIVES:Recent genome-wide association studies revealed that Triggering receptor expressed on myeloid cells 2 (TREM2) was associated with Alzheimer's disease (AD) and other neurodegenerative diseases. We previously reported that TREM2 mRNA is highly expressed in leukocytes of AD patients compared to those in healthy...
journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2017.04.003
更新日期:2017-09-01 00:00:00
abstract::The etiology of schizophrenia continues to be confounding and elusive. Some knowledge gaps exist in the neurodegenerative theory of schizophrenia. Oxidative DNA damage and repair deficits are relevant to the mechanisms of neurodegeneration but have not been studied in drug naïve schizophrenia. The present study used t...
journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2015.05.018
更新日期:2015-09-01 00:00:00
abstract::Elevated rates of cigarette smoking are observed prior to the onset of psychosis and remain stable early in the illness. Cannabis use frequently co-occurs with cigarette smoking and is independently associated with distinct clinical outcomes. However, past research has not controlled for cannabis use in cigarette smok...
journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2016.10.022
更新日期:2017-02-01 00:00:00
abstract::Platelet alpha 2-adrenoceptor number and affinity were measured in 31 drug-free patients with major depressive illness utilizing 3H-clonidine as ligand. A significant negative correlation was found between number of alpha 2-adrenoceptors, baseline urinary 4-hydroxy-3-methoxyphenylglycol (MHPG) excretion, present age a...
journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/0022-3956(85)90077-9
更新日期:1985-01-01 00:00:00
abstract::There is growing evidence for a relationship between the duration of untreated psychosis (DUP) and the prognosis in schizophrenia. The objective of this study is to evaluate whether DUP and premorbid level of social functioning are related to treatment response in acute treatment of first-episode schizophrenia. Sevent...
journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/s0022-3956(03)00104-3
更新日期:2004-03-01 00:00:00
abstract:BACKGROUND:Few studies have investigated protective factors against suicide. OBJECTIVES:To identify whether reasons for living (RFL), measured with the Reasons for Living Inventory (RFLI), protect against suicidal ideation (SI), attempts (SA) and suicide death. METHOD:This systematic review followed the PRISMA (Prefe...
journal_title:Journal of psychiatric research
pub_type: 杂志文章,评审
doi:10.1016/j.jpsychires.2016.02.019
更新日期:2016-06-01 00:00:00
abstract::Thirty-one elderly depressed patients were treated for seven weeks with nortriptyline with plasma levels kept between 50-180 ng/ml. Electrocardiograms were taken at the third and seventh weeks of treatment. There were significant increases in the PR interval, QTc interval, and heart rate from before and after treatmen...
journal_title:Journal of psychiatric research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0022-3956(89)90019-8
更新日期:1989-01-01 00:00:00
abstract:OBJECTIVE:The requirement in classificatory systems that some impairment from attention-deficit/hyperactivity disorder (ADHD) symptoms starts before 7 years of age (age of onset of impairment criteria - AOC) has been harshly criticized. Although there is evidence that late-onset ADHD is a valid diagnosis, little is kno...
journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2008.10.001
更新日期:2009-04-01 00:00:00
abstract::Learning health systems use data to generate knowledge that informs clinical care, but few studies have evaluated how to leverage patient-reported mental health symptoms and substance use data to make patient-specific predictions. We developed a general Bayesian prediction algorithm that uses self-reported psychiatric...
journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2020.12.049
更新日期:2020-12-19 00:00:00
abstract::Prevalence figures of depression usually show a sex ratio for males:females of 1:2. This unequal ratio has been examined by varying the time periods for the calculation of prevalance rates and the criteria for case definition. Based on results of a 20-23 yr-old cohort of 591 males and females studied in Switzerland, s...
journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/0022-3956(84)90029-3
更新日期:1984-01-01 00:00:00
abstract::Familial risk and environmental stress promote the development of alcohol dependence. We investigated whether a positive family history of alcoholism affects the neuroendocrine response to a standardized laboratory stress test in healthy subjects without alcohol use disorders. Twenty-four high-risk subjects with a pat...
journal_title:Journal of psychiatric research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.jpsychires.2003.11.009
更新日期:2004-07-01 00:00:00
abstract::Previous studies have reported abnormalities either in the cAMP-dependent endogenous phosphorylation or in the levels of Rap1 in platelets from bipolar patients. One limitation of these findings was that they come from different groups of patients in independent studies. To overcome this limitation, we designed the pr...
journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/s0022-3956(99)00047-3
更新日期:2000-03-01 00:00:00
abstract::A dysregulation of the hypothalamic-pituitary-adrenocortical (HPA) axis represents a prominent finding in major depression, possibly related to a dysfunction of the corticosteroid receptor system. Antidepressants are involved in the restoration of the altered feed-back mechanism of the HPA-axis, probably via normaliza...
journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2011.03.007
更新日期:2011-09-01 00:00:00
abstract::Depression not only creates enormous costs for treatment and lost work time, but also increases the risk for other costly chronic diseases such as cardiovascular disease and diabetes. The magnitude of these risks remains unclear, with existing prospective studies using small sample sizes with limited diversity and rel...
journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2020.02.030
更新日期:2020-06-01 00:00:00