Abstract：
:Borderline personality disorder (BPD) is marked by aggression and impulsive, often self-destructive behavior. Despite the severe risks associated with BPD, relatively little is known about the disorder's etiology. Identification of genetic correlates (endophenotypes) of BPD would improve the prospects of targeted interventions for more homogeneous subsets of borderline patients characterized by specific genetic vulnerabilities. The current study evaluated behavioral measures of aggression and impulsivity as potential endophenotypes for BPD. Subjects with BPD (N=127), a non cluster B personality disorder (OPD N=122), or healthy volunteers (HV N=112) completed self report and behavioral measures of aggression, motor impulsivity and cognitive impulsivity. Results showed that BPD subjects demonstrated more aggression and motor impulsivity than HV (but not OPD) subjects on behavioral tasks. In contrast, BPD subjects self-reported more impulsivity and aggression than either comparison group. Subsequent analyses showed that among BPD subjects behavioral aggression was associated with self-reported aggression, while behavioral and self-report impulsivity measures were more modestly associated. Overall, the results provide partial support for the use of behavioral measures of aggression and motor impulsivity as endophenotypes for BPD, with stronger support for behavioral aggression measures as an endophenotype for aggression within BPD samples.
journal_name
J Psychiatr Resjournal_title
Journal of psychiatric researchauthors
McCloskey MS,New AS,Siever LJ,Goodman M,Koenigsberg HW,Flory JD,Coccaro EFdoi
10.1016/j.jpsychires.2009.01.002subject
Has Abstractpub_date
2009-08-01 00:00:00pages
1036-48issue
12eissn
0022-3956issn
1879-1379pii
S0022-3956(09)00012-0journal_volume
43pub_type
杂志文章abstract：:Evidence is accumulating that aldosterone may exert central actions and influence mental functions. The aim of the present study was to test the hypothesis that major depressive disorder affects the diurnal variation of salivary aldosterone and that aldosterone concentrations reflect the duration and severity of the d...
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abstract：:Dysfunction of the N-methyl-d-aspartate receptor, which is modulated by excitatory amino acids (EAA), is involved in the pathophysiology of schizophrenia. The effects of antipsychotics on EAA metabolism are uncertain. Positive clinical effects of treatment with antipsychotics were not always associated with changes in...
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journal_title：Journal of psychiatric research
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journal_title：Journal of psychiatric research
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更新日期：1994-05-01 00:00:00
abstract：BACKGROUND:This nationwide population-based study investigated the risk of Parkinson's disease (PD) after zolpidem use in patients with sleep disturbance using the National Health Insurance Research Database (NHIRD) in Taiwan. MATERIAL AND METHODS:In total, 59,548 adult patients newly diagnosed with sleep disturbance ...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2014.07.003
更新日期：2014-11-01 00:00:00
abstract：INTRODUCTION:Those suicide attempters that choose violent methods dramatically diminish the possibility of survival. Completed suicide using violent means, which is common among first-time suicide attempters, was recently found to be more likely among T allele carriers in the three most common ABCB1 SNPs, encoding for ...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2014.12.005
更新日期：2015-02-01 00:00:00
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journal_title：Journal of psychiatric research
pub_type： 杂志文章
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更新日期：2012-09-01 00:00:00
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journal_title：Journal of psychiatric research
pub_type： 杂志文章
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更新日期：1991-01-01 00:00:00
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journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2010.05.017
更新日期：2011-02-01 00:00:00
abstract：:Impairments in social cognition have been documented in severe alcohol use disorder (SAUD) over the past two decades. They have been linked with lower social functioning and poor treatment outcomes, illustrating their key role in the disorder. However, studies investigating social cognition in SAUD have largely focuse...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2020.06.031
更新日期：2020-10-01 00:00:00
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journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2020.02.006
更新日期：2020-04-01 00:00:00
abstract：:The methylenetetrahydrofolate reductase (MTHFR) C677T mutation has been associated to high homocysteine levels and schizophrenia. Since cytokines are altered in schizophrenia and increments of homocysteine could promote an inflammatory response, it was investigated whether interleukin-6 (IL-6) and tumor necrosis facto...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2009.10.011
更新日期：2010-05-01 00:00:00
abstract：OBJECTIVE:Diffusion magnetic resonance imaging (dMRI) enables non-invasive characterization of white matter (WM) structures in vivo. Prior studies suggest that certain WM tracts may be affected in major depressive disorder (MDD), however, hippocampal subfield-specific dMRI measures have not yet been explored in MDD. We...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2019.02.008
更新日期：2019-04-01 00:00:00
abstract：:Glutamatergic therapies are emerging as the new path for the treatment of Major Depression Disorder. Recent reports reviewing the use of glutamate activity modulators in the treatment of resistant depression advocate the importance of understanding the alterations of the diverse components of this complex system in mo...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2013.04.007
更新日期：2013-09-01 00:00:00
abstract：:The neuregulin-1 (NRG1) gene on chromosome 8p has been suggested as a potential susceptibility gene for schizophrenia. The exact way in which genetic variation in NRG1 might impact on this susceptibility for the disorder is a focus of current research. The present study aimed at investigating the possible relationship...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2008.01.009
更新日期：2008-11-01 00:00:00
abstract：OBJECTIVES:Impaired response inhibition underlies symptoms and altered functioning in patients with bipolar disorders (BD). The interpretation of fMRI studies requires an accurate estimation of neurocognitive performance, for which individual studies are typically underpowered. Thus, we performed the first combined met...
journal_title：Journal of psychiatric research
pub_type： 杂志文章,meta分析
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更新日期：2013-12-01 00:00:00
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journal_title：Journal of psychiatric research
pub_type： 杂志文章
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更新日期：2002-11-01 00:00:00
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journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2018.09.001
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journal_title：Journal of psychiatric research
pub_type： 杂志文章
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更新日期：2021-01-11 00:00:00
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journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2008.10.009
更新日期：2009-05-01 00:00:00
abstract：:Veterans have high rates of suicide, and nonsuicidal self-injury (NSSI) is one of the strongest predictors of suicide risk; however, there is presently little known about antecedents of NSSI that might inform intervention efforts. Accumulating research suggests that anger and hostility play an important role in NSSI, ...
journal_title：Journal of psychiatric research
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abstract：:Although considerable empirical work has been devoted to identifying risk factors for suicide attempts, most longitudinal research has studied recurrent attempts rather than first lifetime attempts. The present study sought to examine prospective predictors of first lifetime suicide attempts among adults receiving tre...
journal_title：Journal of psychiatric research
pub_type： 杂志文章,多中心研究
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更新日期：2017-01-01 00:00:00
abstract：:People with a psychiatric illness are at high risk for suicide; however, variation of the risk by patients' sex and age and by specific diagnosis needs to be explored in a more detail. This large population study systematically assesses suicide incidence rate ratio (IRR) and population attributable risk (PAR) associat...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
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更新日期：2011-11-01 00:00:00
abstract：BACKGROUND:Resilience, the ability to adapt positively to adversity, may be an important factor in successful aging. However, the assessment and correlates of resilience in elderly individuals have not received adequate attention. METHOD:A total of 1395 community-dwelling women over age 60 who were participants at the...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2008.03.007
更新日期：2008-12-01 00:00:00
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journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2010.03.015
更新日期：2010-11-01 00:00:00
abstract：:Although schizophrenia and obsessive-compulsive disorder (OCD) are distinct diagnostic entities, there are substantial areas of overlap between the two disorders in clinical characteristics, affected brain areas and pharmacotherapy. Though OCD patients apparently do not have increased risk for developing schizophrenia...
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pub_type： 杂志文章,评审
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更新日期：2005-07-01 00:00:00
