Abstract:
:The aggregation of disorder in families identified by a schizophrenic disorder proband (index case) has provided indirect clues to the question of diagnostic boundaries of schizophrenic spectrum categories. The Danish Adoption Studies provided quasi-experimental evidence for the range of expression of a putative schizophrenic spectrum disorder which was subsequently denoted schizotypal personality disorder (STPD) in DSM-III-R. It has been hypothesized that such schizophrenic spectrum categories bear a genetic relationship to schizophrenic disorder and thus are continuous with schizophrenia in terms of etiology and pathogenesis. For meaningful use of such spectrum categories in genetic analyses, i.e., linkage analysis, it is important that rates of spectrum traits and disorder in normal control and in psychiatric control populations are known. The rate of DSM-III-R schizotypal traits and disorder was assessed in three offspring groups (ages 18-29) defined by parental diagnoses, including schizophrenic disorder (N = 90), affective disorder (N = 79), and no parental disorder (N = 161). The assessment was conducted by trained social workers and psychologists by means of a direct interview (Personality Disorder Examination). The interviewers were blind to the parental status and to previous psychiatric assessments of these offspring. The rates of three, four and five schizotypal features were elevated in the offspring with parental psychiatric disorder in contrast to the offspring with no parental psychiatric disorder. However, the rates between the offspring of the schizophrenic disorder parental group and the offspring of the affective disorder parental group did not differ significantly, thus failing to support the assumption of diagnostic specificity.
journal_name
J Psychiatr Resjournal_title
Journal of psychiatric researchauthors
Squires-Wheeler E,Skodol AE,Bassett A,Erlenmeyer-Kimling Ldoi
10.1016/0022-3956(89)90028-9subject
Has Abstractpub_date
1989-01-01 00:00:00pages
229-39issue
3-4eissn
0022-3956issn
1879-1379journal_volume
23pub_type
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journal_title:Journal of psychiatric research
pub_type: 杂志文章
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journal_title:Journal of psychiatric research
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abstract::Gilles de la Tourette syndrome (GTS) can manifest as debilitating, medically-refractory tics for which deep brain stimulation (DBS) of the centromedian-parafascicular complex (CM) can provide effective treatment. However, patients have reported benefit with activation of contacts dorsal to the CM and likely in the ven...
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journal_title:Journal of psychiatric research
pub_type: 杂志文章,多中心研究
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journal_title:Journal of psychiatric research
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journal_title:Journal of psychiatric research
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journal_title:Journal of psychiatric research
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journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2014.06.011
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journal_title:Journal of psychiatric research
pub_type: 杂志文章,meta分析
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pub_type: 杂志文章
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journal_title:Journal of psychiatric research
pub_type: 杂志文章
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journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2011.10.009
更新日期:2012-02-01 00:00:00
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journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2017.04.011
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pub_type: 杂志文章,评审
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journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2014.06.021
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journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2012.04.019
更新日期:2012-08-01 00:00:00
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journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2013.04.012
更新日期:2013-10-01 00:00:00
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journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2012.11.017
更新日期:2013-04-01 00:00:00
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journal_title:Journal of psychiatric research
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.jpsychires.2015.07.005
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journal_title:Journal of psychiatric research
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Journal of psychiatric research
pub_type: 杂志文章
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更新日期:2009-04-01 00:00:00
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journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2012.09.017
更新日期:2013-02-01 00:00:00
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journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2020.02.020
更新日期:2020-05-01 00:00:00
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journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2020.06.002
更新日期:2020-10-01 00:00:00
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journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2020.11.017
更新日期:2020-11-09 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.jpsychires.2010.11.003
更新日期:2011-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:2003-11-01 00:00:00
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journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2009.01.002
更新日期:2009-08-01 00:00:00
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journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2018.09.001
更新日期:2018-10-01 00:00:00