Abstract:
:Various studies have assessed autonomic and respiratory underpinnings of panic attacks, yet the psychophysiological functioning of panic disorder (PD) patients has rarely been examined under naturalistic conditions at times when acute attacks were not reported. We hypothesized that emotional activation in daily life causes physiologically demonstrable deviations from efficient metabolic regulation in PD patients. Metabolic coupling was estimated as within-individual correlations between heart rate (HR) and indices of metabolic activity, i.e., physical activity (measured by 3-axial accelerometry, Acc), and minute ventilation (Vm, measured by calibrated inductive plethysmography, as proxy for oxygen consumption). A total of 565 daytime hours were recorded in 19 PD patients and 20 healthy controls (HC). Pairwise cross-correlations of minute-by-minute averages of these metabolic indices were calculated for each participant and then correlated with several indices of self-reported anxiety. Ambulatory HR was elevated in PD (p = .05, d = 0.67). Patients showed reduced HR-Acc (p < .006, d = 0.97) and HR-Vm coupling (p < .009, d = 0.91). Combining Vm and Acc to predict HR showed the strongest group separation (p < .002, d = 1.07). Discriminant analyses, based on the combination of Vm and Acc to predict HR, classified 77% of all participants correctly. In PD, HR-Acc coupling was inversely related to trait anxiety sensitivity, as well as tonic and phasic daytime anxiety. The novel method that was used demonstrates that anxiety in PD may reduce efficient long-term metabolic coupling. Metabolic decoupling may serve as physiological characteristic of PD and might aid diagnostics for PD and other anxiety disorders. This measure deserves further study in research on health consequences of anxiety and psychosocial stress.
journal_name
J Psychiatr Resjournal_title
Journal of psychiatric researchauthors
Pfaltz MC,Kolodyazhniy V,Blechert J,Margraf J,Grossman P,Wilhelm FHdoi
10.1016/j.jpsychires.2015.04.027subject
Has Abstractpub_date
2015-09-01 00:00:00pages
377-83eissn
0022-3956issn
1879-1379pii
S0022-3956(15)00130-2journal_volume
68pub_type
杂志文章abstract::Several lines of evidence, including psychopathological, neurobiological, pharmacological and epidemiological data, supported the association between Anorexia Nervosa (AN) and Obsessive-Compulsive Disorder (OCD). The aim of the present study is to test the hypothesis of partial common genetic background of both diseas...
journal_title:Journal of psychiatric research
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pub_type: 杂志文章,meta分析,评审
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journal_title:Journal of psychiatric research
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journal_title:Journal of psychiatric research
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journal_title:Journal of psychiatric research
pub_type: 杂志文章,评审
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journal_title:Journal of psychiatric research
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pub_type: 杂志文章,meta分析
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journal_title:Journal of psychiatric research
pub_type: 杂志文章,随机对照试验
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journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/0022-3956(66)90020-3
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journal_title:Journal of psychiatric research
pub_type: 临床试验,杂志文章
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journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2012.02.011
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journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2018.04.008
更新日期:2018-07-01 00:00:00
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journal_title:Journal of psychiatric research
pub_type: 杂志文章,评审
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pub_type: 杂志文章
doi:10.1016/j.jpsychires.2010.03.005
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journal_title:Journal of psychiatric research
pub_type: 杂志文章
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journal_title:Journal of psychiatric research
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Journal of psychiatric research
pub_type: 杂志文章
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journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2011.04.001
更新日期:2011-09-01 00:00:00
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journal_title:Journal of psychiatric research
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Journal of psychiatric research
pub_type: 杂志文章,评审
doi:10.1016/j.jpsychires.2017.04.007
更新日期:2017-09-01 00:00:00
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pub_type: 杂志文章
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