Abstract：
BACKGROUND:Structural neuroimaging studies revealed a consistent pattern of volumetric reductions in both hippocampus (HC) and anterior cingulate cortex (ACC) of individuals with major depressive episode(s) (MDE). This study investigated HC and ACC volume differences in currently depressed individuals (n = 150), individuals with a past lifetime MDE history (n = 79) and healthy controls (n = 287). METHODS:Non-demented individuals were recruited from a cohort of community-dwelling older adults (ESPRIT study). T1-weighted magnetic resonance images and FreeSurfer Software (automated method) were used. Concerning HC, a manual method of measurement dividing HC into head, body, and tail was also used. General Linear Model was applied adjusting for covariates. RESULTS:Current depression was associated with lower left posterior HC volume, using manual measurement, in comparison to healthy status. However, when we slightly changed sub-group inclusion criteria, results did not survive to correction for multiple comparisons. CONCLUSIONS:The finding of lower left posterior HC volume in currently depressed individuals but not in those with a past MDE compared to healthy controls could be related to brain neuroplasticity. Additionally, our results may suggest manual measures to be more sensitive than automated methods.
journal_name
J Psychiatr Resjournal_title
Journal of psychiatric researchauthors
Bensassi I,Lopez-Castroman J,Maller JJ,Meslin C,Wyart M,Ritchie K,Courtet P,Artero S,Calati Rdoi
10.1016/j.jpsychires.2018.04.008subject
Has Abstractpub_date
2018-07-01 00:00:00pages
159-167eissn
0022-3956issn
1879-1379pii
S0022-3956(17)31415-2journal_volume
102pub_type
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journal_title：Journal of psychiatric research
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pub_type： 杂志文章,评审
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doi：10.1016/j.jpsychires.2012.04.012
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