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Familiality of clinical characteristics in schizophrenia.

Abstract：

:Few studies have assessed the familiality of clinical characteristics in schizophrenia. Therefore, we set out to investigate the familiality of the following characteristics; age of onset, course of disorder, employment status at onset, impairment during disorder, marital status at onset, mode of onset and premorbid functioning. Clinical characteristics were recorded using the Operational Criteria Checklist for Psychotic Illness for 155 subjects with an RDC diagnosis of schizophrenia, schizoaffective disorder, or psychosis of unknown origin, from 61 families multiply affected by schizophrenia. Age of onset, course of disorder, impairment during disorder, mode of onset, and premorbid functioning were shown to be familial. The familiality of these clinical characteristics supports their use in the delineation of homogeneous subsets for future genetic studies.

journal_name

J Psychiatr Res

journal_title

Journal of psychiatric research

authors

Wickham H,Walsh C,Asherson P,Gill M,Owen MJ,McGuffin P,Murray R,Sham P

doi

10.1016/s0022-3956(02)00008-0

subject

Has Abstract

pub_date

2002-09-01 00:00:00

pages

325-9

issue

5

eissn

0022-3956

issn

1879-1379

pii

S0022395602000080

journal_volume

36

pub_type

杂志文章

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