Abstract:
:The antisaccade task is well suited to study the interplay between environmental stimuli and action goals in controlling behavior. It requires subjects to look to the mirror position of visual stimuli. Schizophrenia patients usually show enhanced rates of erroneous saccades toward the stimulus. The present study was designed to investigate the role of task set activation and error detection for this impairment. Fifteen patients with a diagnosis of schizophrenia and 15 control subjects made antisaccades under standard conditions and under precue conditions. In the precue conditions the imperative visual stimulus was immediately preceded by short precues on either the same or the opposite side. Subjects had to evaluate their performance on each trial. Schizophrenia patients showed enhanced error rates on the standard condition and after same side precues but not after opposite side precues. Opposite side precues entailed increased errors in both groups, but the increase was weaker in schizophrenia patients. This lower precue effect in schizophrenia is proposed to reflect reduced activation of the task set for antisaccades in schizophrenia. The study also revealed strongly impaired error detection in schizophrenia. The relative roles of task-set activation and error detection for poor antisaccade performance in schizophrenia are discussed.
journal_name
J Psychiatr Resjournal_title
Journal of psychiatric researchauthors
Reuter B,Herzog E,Kathmann Ndoi
10.1016/j.jpsychires.2005.02.007subject
Has Abstractpub_date
2006-03-01 00:00:00pages
122-30issue
2eissn
0022-3956issn
1879-1379pii
S0022-3956(05)00034-8journal_volume
40pub_type
杂志文章abstract::Smooth pursuit eye movement (SPEM) performance has been linked to nonvoluntary attentional processes. Amphetamine is a psychotropic drug with documented effects on attentional performance. In order to evaluate the relationship between SPEM performance and amphetamine's attentional effects, SPEM performance was measure...
journal_title:Journal of psychiatric research
pub_type: 临床试验,杂志文章
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更新日期:1987-01-01 00:00:00
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journal_title:Journal of psychiatric research
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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更新日期:1985-01-01 00:00:00
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pub_type: 杂志文章
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pub_type: 临床试验,杂志文章,随机对照试验
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