Abstract:
:We compared scores from three different ratings methods in a clinical trial of patients with Major Depressive Disorder (MDD). The Quick Inventory of Depressive Symptoms (QIDS-SR16) was compared to site-based clinician and centralized (site-independent) ratings of the Inventory of Depressive Symptoms (IDSc30). An extracted QIDSc16 was used for a matched comparison with the QIDS-SR16. Patient self-ratings were more depressed at baseline than either site-based ratings (p = 0.131) or centralized ratings (p = 0.005), but significantly less depressed at the end of double-blind treatment than either site-based (p = 0.006) or centralized ratings (p = 0.014), and after 12 weeks (site-based ratings: p = 0.048; centralized ratings: p = 0.004). The matched comparisons with patient self-ratings revealed ICC of r = 0.55 (site-based raters) and r = 0.49 (centralized raters) at baseline. After baseline, the correlations between the two different clinician ratings and patient self-ratings improved to r-values between 0.78 and 0.89. At the end of double-blind treatment, site-based raters separated the combination treatment from placebo on the IDSc30 (p = 0.030) whereas neither centralized ratings nor patient self-ratings achieved statistical significance. Alternatively, patient self-ratings separated the combination treatment from buspirone (p = 0.030) whereas neither clinician rating method achieved significance. A "dual" scoring concordance range reduced the placebo response rate and increased the drug effect between the combination treatment and placebo. These findings reveal scoring variability between each of the three ratings methods and challenge the reliability of any single method to accurately assess symptom severity scores, particularly at baseline. The use of "dual" scoring criteria may help to confirm symptom severity scores and improve ratings precision, particularly prior to enrolling subjects into CNS trials.
journal_name
J Psychiatr Resjournal_title
Journal of psychiatric researchauthors
Targum SD,Wedel PC,Robinson J,Daniel DG,Busner J,Bleicher LS,Rauh P,Barlow Cdoi
10.1016/j.jpsychires.2013.02.016subject
Has Abstractpub_date
2013-07-01 00:00:00pages
944-54issue
7eissn
0022-3956issn
1879-1379pii
S0022-3956(13)00082-4journal_volume
47pub_type
临床试验,杂志文章,随机对照试验abstract::There are very few magnetic resonance spectroscopy studies in anorexia nervosa and none of them with young adolescent patients. We studied 12 anorexia nervosa (DSM-IV) patients aged 11-17 consecutively admitted to an Eating Disorders Unit. An evaluation with laboratory data, psychopathological scales, magnetic resonan...
journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2006.09.013
更新日期:2007-12-01 00:00:00
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journal_title:Journal of psychiatric research
pub_type: 杂志文章
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abstract::It is generally accepted that patients with major depressive disorder have smaller hippocampus size compared to healthy people. However, it is still not known if this situation exists before the onset of the disease or is a result of the toxic mechanism created by the depression itself. The findings of the long-term f...
journal_title:Journal of psychiatric research
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journal_title:Journal of psychiatric research
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journal_title:Journal of psychiatric research
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journal_title:Journal of psychiatric research
pub_type: 杂志文章,多中心研究
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journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2012.09.006
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abstract::Depression has a chronic and recurrent course often with early onset and is the leading cause of disability worldwide. In contrast to diagnoses for other conditions which rely on precise medical tests, the diagnosis of depression still focuses exclusively on symptom reports. As a result, heterogeneous patient groups a...
journal_title:Journal of psychiatric research
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journal_title:Journal of psychiatric research
pub_type: 杂志文章,meta分析,评审
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journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/0022-3956(88)90007-6
更新日期:1988-01-01 00:00:00
abstract::Cognitive-behavioral therapy (CBT) constitutes an empirically based treatment for tic disorders (TD), but much remains to be learned about its impact at the neural level. Therefore, we examined the electrophysiological correlates of CBT in TD patients, and we evaluated the utility of event-related potentials (ERP) as ...
journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2018.08.020
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:Patients with posttraumatic stress disorder (PTSD) are at increased risk for adverse consequences from comorbid medical conditions. Nonadherence to medications prescribed to treat those comorbid conditions may help explain this increased risk. We sought to determine the association between PTSD and medicatio...
journal_title:Journal of psychiatric research
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.jpsychires.2018.02.013
更新日期:2018-07-01 00:00:00
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journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2020.12.049
更新日期:2020-12-19 00:00:00
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journal_title:Journal of psychiatric research
pub_type: 杂志文章,meta分析
doi:10.1016/j.jpsychires.2017.04.004
更新日期:2017-09-01 00:00:00
abstract::Cognitive-behavioral therapy (CBT) alleviates symptoms of depression in youth with bipolar disorder (BD) and major depressive disorder (MDD). Empirical research has linked inflammatory markers to depressive symptoms and acute psychosocial stress; however, a gap remains as to whether immune response to stress may serve...
journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2019.10.012
更新日期:2020-01-01 00:00:00
abstract::Measurements of the ventricular brain ratio (VBR), width of the sylvian fissure, and symmetry of the frontal lobes were obtained from 26 chronic schizophrenic patients, 22 alcoholic and neurological patients, and 20 normal controls. All schizophrenic subjects were non-responsive to long-term neuroleptic medication for...
journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/0022-3956(82)90042-5
更新日期:1982-01-01 00:00:00
abstract::Reports have described how psychiatric patients respond to disasters. However, previous reports on the response depending on diagnostic categories have provided no clear consensus. Here we analyzed response to the Great East Japan Earthquake of March 11, 2011, among psychiatric patients in light of severity of pre-exi...
journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2013.06.006
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abstract::Deep transcranial magnetic stimulation (DTMS) is a non-invasive brain stimulation method mostly utilised in the treatment of major depression. The aim of the current study was to systematically review the literature on the cognitive effects of DTMS applied with the H-coil system in major psychiatric disorders. Followi...
journal_title:Journal of psychiatric research
pub_type: 杂志文章,评审
doi:10.1016/j.jpsychires.2015.12.019
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journal_title:Journal of psychiatric research
pub_type: 临床试验,杂志文章
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journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2005.11.001
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journal_title:Journal of psychiatric research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.jpsychires.2009.09.013
更新日期:2010-04-01 00:00:00
abstract::Glutamatergic therapies are emerging as the new path for the treatment of Major Depression Disorder. Recent reports reviewing the use of glutamate activity modulators in the treatment of resistant depression advocate the importance of understanding the alterations of the diverse components of this complex system in mo...
journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2013.04.007
更新日期:2013-09-01 00:00:00
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journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2020.07.038
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journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2008.05.007
更新日期:2009-01-01 00:00:00
abstract::A fraction of genetic risk to develop schizophrenia may be due to low-frequency variants. This multistep study attempted to find low-frequency variants of high effect at coding regions of eleven schizophrenia susceptibility genes supported by genome-wide association studies (GWAS) and nine genes for the DISC1 interact...
journal_title:Journal of psychiatric research
pub_type: 杂志文章,meta分析
doi:10.1016/j.jpsychires.2015.04.013
更新日期:2015-07-01 00:00:00
abstract:OBJECTIVE:To examine gender differences in the associations of levels of pain interference and psychiatric disorders among a nationally representative sample of adult men and women. METHOD:Chi-square tests and multinomial logistic regression analyses were performed on data obtained from the National Epidemiologic Surv...
journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2011.09.004
更新日期:2012-01-01 00:00:00
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journal_title:Journal of psychiatric research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jpsychires.2005.08.009
更新日期:2007-10-01 00:00:00
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journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/s0022-3956(02)00050-x
更新日期:2002-11-01 00:00:00
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journal_title:Journal of psychiatric research
pub_type: 杂志文章
doi:10.1016/j.jpsychires.2006.02.010
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