当前位置： SCI文献检索 > JOURNAL OF PSYCHIATRIC RESEARCH期刊下所有文献 > The metabolic effects of antipsychotics in the early stage of treatment in first-episode patients with schizophrenia: A real-world study in a naturalistic setting.

The metabolic effects of antipsychotics in the early stage of treatment in first-episode patients with schizophrenia: A real-world study in a naturalistic setting.

Abstract：

OBJECTIVE:This study aims to better characterize the metabolic effects of antipsychotics in the early stage of treatment in first-episode patients with schizophrenia. METHODS:We performed a retrospective real-world study in a naturalistic setting that included inpatients with first-episode drug-naïve schizophrenia; metabolic profiles were measured at baseline and 2 weeks and 4 weeks after antipsychotic treatment. The metabolic profiles of medicated patients with first-episode schizophrenia were also included. RESULTS:Insulin resistance, based on the ratio of triglycerides to high-density lipoprotein cholesterol (TG/HDL-C), increased significantly after 2 weeks of antipsychotic treatment, whereas fasting glucose (FG) decreased significantly. Regarding lipid metabolism, triglycerides (TG), cholesterol (CHOL) and low-density lipoprotein cholesterol (LDL-C) increased significantly after 2 weeks of antipsychotic treatment; however, high-density lipoprotein cholesterol (HDL-C) decreased significantly after 4 weeks of antipsychotic treatment. There were no statistically significant differences between the antipsychotic groups in any of the metabolic parameters evaluated. CONCLUSION:Our study revealed that insulin resistance and lipid metabolic abnormalities occurred as early as two weeks after the initiation of antipsychotic treatment. Our findings suggest that metabolic profiles should been monitored in the early stage of antipsychotics treatment in clinical practice. Further research is needed to explore the underlying mechanisms of the short-term effects of antipsychotics on metabolic parameters.

journal_name

J Psychiatr Res

journal_title

Journal of psychiatric research

authors

Cao H,Meng Y,Li X,Ma X,Deng W,Guo W,Li T

doi

10.1016/j.jpsychires.2020.07.038

subject

Has Abstract

pub_date

2020-10-01 00:00:00

pages

265-271

eissn

0022-3956

issn

1879-1379

pii

S0022-3956(20)30903-1

journal_volume

129

pub_type

杂志文章

相关文献

JOURNAL OF PSYCHIATRIC RESEARCH文献大全
  • The nosology of abuse and dependence.

    abstract：:Physicians who prescribe benzodiazepines often are asked by their patients if these drugs might be addicting or have potential for abuse. Clarifying these concepts is difficult because of numerous "gray areas" of drug use and confusion over medical criteria for such terms as "addiction", "dependence", and "tolerance"....

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章,评审

    doi：10.1016/0022-3956(90)90036-p

    authors： Kleber HD

    更新日期：1990-01-01 00:00:00

  • Effects of hypnotics on the sleep EEG of healthy young adults: new data and psychopharmacologic implications.

    abstract：:Benzodiazepine hypnotics increase NREM sleep and alter its EEG by reducing delta (0.3-3 Hz) and increasing sigma (12-15 Hz) and beta (15-23 Hz) activity. We tested whether the nonbenzodiazepine hypnotic, zolpidem (10 mg), produced the same pattern of sleep and EEG changes as two "classical" benzodiazepines, triazolam ...

    journal_title：Journal of psychiatric research

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0022-3956(00)00038-8

    authors： Feinberg I,Maloney T,Campbell IG

    更新日期：2000-11-01 00:00:00

  • DNA methylation changes at TREM2 intron 1 and TREM2 mRNA expression in patients with Alzheimer's disease.

    abstract：OBJECTIVES:Recent genome-wide association studies revealed that Triggering receptor expressed on myeloid cells 2 (TREM2) was associated with Alzheimer's disease (AD) and other neurodegenerative diseases. We previously reported that TREM2 mRNA is highly expressed in leukocytes of AD patients compared to those in healthy...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2017.04.003

    authors： Ozaki Y,Yoshino Y,Yamazaki K,Sao T,Mori Y,Ochi S,Yoshida T,Mori T,Iga JI,Ueno SI

    更新日期：2017-09-01 00:00:00

  • Fast BDNF serum level increase and diurnal BDNF oscillations are associated with therapeutic response after partial sleep deprivation.

    abstract：OBJECTIVE:Preclinical and clinical studies support a role for brain-derived neurotrophic factor (BDNF) in the pathophysiology of stress-related mood disorders. Furthermore, BDNF seems to be linked to antidepressant action. Available pharmacological treatments for depression are characterized by significant limitations ...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2014.09.005

    authors： Giese M,Beck J,Brand S,Muheim F,Hemmeter U,Hatzinger M,Holsboer-Trachsler E,Eckert A

    更新日期：2014-12-01 00:00:00

  • Depressive symptoms, impaired glucose metabolism, high visceral fat, and high systolic blood pressure in a subgroup of women with recent gestational diabetes.

    abstract：:Women with gestational diabetes (GDM) are a high risk group for early type 2 diabetes (T2D). Depression is a risk factor for T2D in the general population. We investigated in women after a recent pregnancy with GDM and without a clinical diagnosis of depression, whether mild to moderate depressive symptoms associate w...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2017.12.001

    authors： Ferrari U,Banning F,Freibothe I,Tröndle K,Sacco V,Wichmann C,Reif S,Moschko S,Potzel A,Gar C,Sommer NN,Popp D,Seissler J,Lechner A,Künzel H

    更新日期：2018-02-01 00:00:00

  • Epigenetics of neuroinflammation: Immune response, inflammatory response and cholinergic synaptic involvement evidenced by genome-wide DNA methylation analysis of delirious inpatients.

    abstract：:Previously our study has shown that the DNA methylation (DNAm) levels at CpG sites in the pro-inflammatory cytokine gene, TNF-alpha, decrease along with aging, suggesting the potential role of DNAm in aging and heightened inflammatory process leading to increased risk for delirium. However, DNAm differences between de...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2020.06.005

    authors： Saito T,Toda H,Duncan GN,Jellison SS,Yu T,Klisares MJ,Daniel S,Andreasen AJ,Leyden LR,Hellman MM,Shinozaki E,Lee S,Yoshino A,Cho HR,Shinozaki G

    更新日期：2020-10-01 00:00:00

  • Decreased prefrontal, anterior cingulate, insula, and ventral striatal metabolism in medication-free depressed outpatients with bipolar disorder.

    abstract：:This study explored whether cerebral metabolic changes seen in treatment resistant and rapid cycling bipolar depression inpatients are also found in an outpatient sample not specifically selected for treatment resistance or rapid cycling. We assessed 15 depressed outpatients with bipolar disorder (six type I and nine ...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2008.04.015

    authors： Brooks JO 3rd,Wang PW,Bonner JC,Rosen AC,Hoblyn JC,Hill SJ,Ketter TA

    更新日期：2009-01-01 00:00:00

  • Possible dysregulation of cortical plasticity in auditory verbal hallucinations-A cortical thickness study in schizophrenia.

    abstract：INTRODUCTION:Investigations of gray matter changes in relation with auditory verbal hallucinations (AVH) have reported conflicting results. Assuming that alterations in gray matter might be related to certain symptoms in schizophrenia this study aimed to investigate changes in cortical thickness specific to AVH. It was...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2012.03.016

    authors： van Swam C,Federspiel A,Hubl D,Wiest R,Boesch C,Vermathen P,Kreis R,Strik W,Dierks T

    更新日期：2012-08-01 00:00:00

  • Intraday weather conditions can influence self-report of depressive symptoms.

    abstract：:The weather is arguably one of the most common topics in daily conversation. However, it is also a well-known factor in psychiatric problems worldwide such as depression, where particularly elders and females are prone to the condition. Previous studies have mostly focused on the association between long-term climate/...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2020.02.006

    authors： Xu C,Wu W,Peng-Li D,Xu P,Sun D,Wan B

    更新日期：2020-04-01 00:00:00

  • Negative association of perceived risk and willingness to participate in innovative psychiatric research protocols.

    abstract：:Psychiatric researchers grapple with concerns that individuals with mental illness may be less likely to appreciate risks of research participation, particularly compared to people not suffering from mental illness. Therefore, empirical studies that directly compare the perspectives of such individuals are needed. In ...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2019.12.010

    authors： Tsungmey T,Kim JP,Dunn LB,Ryan K,Lane-McKinley K,Roberts LW

    更新日期：2020-03-01 00:00:00

  • Childhood trauma and the risk of violence in adulthood in a population with a psychotic illness.

    abstract：:There are strong links between childhood trauma and the risk of violence (Ford et al., 2007). Despite evidence that people with psychotic disorders are at a higher risk of violence than the general population (Witt et al., 2013) there have been few studies that have examined the trauma-violence link in this population...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2014.03.011

    authors： Bosqui TJ,Shannon C,Tiernan B,Beattie N,Ferguson J,Mulholland C

    更新日期：2014-07-01 00:00:00

  • Association between prenatal and perinatal factors and the severity of clinical presentation of children with ASD: Report from the ELENA COHORT.

    abstract：:Many studies have suggested that prenatal and perinatal factors increase the risk for autism spectrum disorder (ASD). However, few reports have addressed the question of their influence on the severity of the clinical presentation of children with ASD. Our objective was to determine the prenatal and perinatal factors ...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2020.11.005

    authors： Traver S,Geoffray MM,Mazières L,Geneviève D,Michelon C,Picot MC,Baghdadli A

    更新日期：2020-11-04 00:00:00

  • Quantification of cell-free DNA in blood plasma and DNA damage degree in lymphocytes to evaluate dysregulation of apoptosis in schizophrenia patients.

    abstract：:Oxidative DNA damage has been proposed as one of the causes of schizophrenia (SZ), and post mortem data indicate a dysregulation of apoptosis in SZ patients. To evaluate apoptosis in vivo we quantified the concentration of plasma cell-free DNA (cfDNA index, determined using fluorescence), the levels of 8-oxodG in cfDN...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2016.12.006

    authors： Ershova ES,Jestkova EM,Chestkov IV,Porokhovnik LN,Izevskaya VL,Kutsev SI,Veiko NN,Shmarina G,Dolgikh O,Kostyuk SV

    更新日期：2017-04-01 00:00:00

  • The outlook for linkage research in psychiatric disorders.

    abstract：:Analysis of the distribution of diagnoses in families (segregation analysis) has not, so far, advanced us toward the goal of resolving the inheritance of the major psychiatric disorders. Recent advances in genetics, particularly the development of new molecular genetic linkage methods, have made it, at least theoretic...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章,评审

    doi：10.1016/0022-3956(87)90103-8

    authors： Gershon ES,Goldin LR

    更新日期：1987-01-01 00:00:00

  • Cognition in offspring of parents with psychotic and non-psychotic severe mental illness.

    abstract：BACKGROUND:Cognitive impairment is a feature of severe mental illness (SMI; schizophrenia, bipolar disorder, major depressive disorder). Psychotic forms of SMI may be associated with greater cognitive impairment, but it is unclear if this differential impairment pre-dates illness onset or whether it reflects a conseque...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2020.08.019

    authors： MacKenzie LE,Howes Vallis E,Rempel S,Zwicker A,Drobinin V,Pavlova B,Uher R

    更新日期：2020-11-01 00:00:00

  • Genetics of the serotonergic system in suicidal behavior.

    abstract：:Genetic factors contribute to the risk of psychopathology in many psychiatric conditions, but the specific genes are yet to be identified. Neurotransmitter alterations are implicated in the etiology of psychopathology based, in part, on studies of neurotransmitter receptors and their biosynthetic or degradative enzyme...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章,评审

    doi：10.1016/s0022-3956(03)00048-7

    authors： Arango V,Huang YY,Underwood MD,Mann JJ

    更新日期：2003-09-01 00:00:00

  • Physiological responsivity to emotional pictures in schizophrenia.

    abstract：:Schizophrenic patients are known to experience difficulties in emotional information processing, yet knowledge of their physiological responsivity to emotional stimuli is limited. The purpose of this study was to investigate the physiological reactions of schizophrenic patients to emotional stimuli. We presented pictu...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2004.11.004

    authors： Hempel RJ,Tulen JH,van Beveren NJ,van Steenis HG,Mulder PG,Hengeveld MW

    更新日期：2005-09-01 00:00:00

  • Hostile attributional bias in severe alcohol use disorder.

    abstract：:Impairments in social cognition have been documented in severe alcohol use disorder (SAUD) over the past two decades. They have been linked with lower social functioning and poor treatment outcomes, illustrating their key role in the disorder. However, studies investigating social cognition in SAUD have largely focuse...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2020.06.031

    authors： Pabst A,Peyroux E,Rolland B,de Timary P,Maurage P

    更新日期：2020-10-01 00:00:00

  • The combination of triiodothyronine (T3) and sertraline is not superior to sertraline monotherapy in the treatment of major depressive disorder.

    abstract：OBJECTIVE:To determine whether the combination of triiodothyronine (T3) plus sertraline at treatment initiation confers greater antidepressant efficacy than sertraline plus placebo in patients with major depressive disorder. METHOD:Eight-week, double blind, randomized placebo controlled clinical trial of 153 adult out...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.jpsychires.2012.08.009

    authors： Garlow SJ,Dunlop BW,Ninan PT,Nemeroff CB

    更新日期：2012-11-01 00:00:00

  • Induced abortion and anxiety, mood, and substance abuse disorders: isolating the effects of abortion in the national comorbidity survey.

    abstract：:The purpose of this study was to examine associations between abortion history and a wide range of anxiety (panic disorder, panic attacks, PTSD, Agoraphobia), mood (bipolar disorder, mania, major depression), and substance abuse disorders (alcohol and drug abuse and dependence) using a nationally representative US sam...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2008.10.009

    authors： Coleman PK,Coyle CT,Shuping M,Rue VM

    更新日期：2009-05-01 00:00:00

  • Aggression and violence in psychiatric hospitals with and without open door policies: A 15-year naturalistic observational study.

    abstract：:Aggressive behavior and violence in psychiatric patients have often been quoted to justify more restrictive settings in psychiatric facilities. However, the effects of open vs. locked door policies on aggressive incidents remain unclear. This study had a naturalistic observational design and analyzed the occurrence of...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2017.08.017

    authors： Schneeberger AR,Kowalinski E,Fröhlich D,Schröder K,von Felten S,Zinkler M,Beine KH,Heinz A,Borgwardt S,Lang UE,Bux DA,Huber CG

    更新日期：2017-12-01 00:00:00

  • Volumetric brain analysis as a predictor of a worse cognitive outcome in Parkinson's disease.

    abstract：:Cognitive impairment in Parkinson's disease (PD) results in significant morbidity and mortality being early diagnosis essential. Identification of patients who are at higher risk of developing cognitive impairment based only on clinical data is not sufficient. To this end, magnetic resonance imaging (MRI) with automat...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2018.04.016

    authors： Vasconcellos LF,Pereira JS,Adachi M,Greca D,Cruz M,Malak AL,Charchat-Fichman H

    更新日期：2018-07-01 00:00:00

  • Functional neuroanatomy of response inhibition in bipolar disorders--combined voxel based and cognitive performance meta-analysis.

    abstract：OBJECTIVES:Impaired response inhibition underlies symptoms and altered functioning in patients with bipolar disorders (BD). The interpretation of fMRI studies requires an accurate estimation of neurocognitive performance, for which individual studies are typically underpowered. Thus, we performed the first combined met...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.jpsychires.2013.08.015

    authors： Hajek T,Alda M,Hajek E,Ivanoff J

    更新日期：2013-12-01 00:00:00

  • Immune response to stress induction as a predictor of cognitive-behavioral therapy outcomes in adolescent mood disorders: A pilot study.

    abstract：:Cognitive-behavioral therapy (CBT) alleviates symptoms of depression in youth with bipolar disorder (BD) and major depressive disorder (MDD). Empirical research has linked inflammatory markers to depressive symptoms and acute psychosocial stress; however, a gap remains as to whether immune response to stress may serve...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2019.10.012

    authors： Pearlstein JG,Staudenmaier PJ,West AE,Geraghty S,Cosgrove VE

    更新日期：2020-01-01 00:00:00

  • Frequency and correlates of anxiety symptoms during the COVID-19 pandemic in low- and middle-income countries: A multinational study.

    abstract：OBJECTIVE:Studies have documented the significant direct and indirect psychological, social, and economic consequences of the Coronavirus disease 2019 (COVID-19) in many countries but little is known on its impact in low- and middle-income countries (LMICs) already facing difficult living conditions and having vulnerab...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jpsychires.2020.09.031

    authors： Cénat JM,Dalexis RD,Guerrier M,Noorishad PG,Derivois D,Bukaka J,Birangui JP,Adansikou K,Clorméus LA,Kokou-Kpolou CK,Ndengeyingoma A,Sezibera V,Auguste RE,Rousseau C

    更新日期：2021-01-01 00:00:00

  • Age of onset of bipolar disorder: Combined effect of childhood adversity and familial loading of psychiatric disorders.

    abstract：BACKGROUND:Family history and adversity in childhood are two replicated risk factors for early onset bipolar disorder. However, their combined impact has not been adequately studied. METHODS:Based on questionnaire data from 968 outpatients with bipolar disorder who gave informed consent, the relationship and interacti...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2016.06.008

    authors： Post RM,Altshuler LL,Kupka R,McElroy SL,Frye MA,Rowe M,Grunze H,Suppes T,Keck PE Jr,Leverich GS,Nolen WA

    更新日期：2016-10-01 00:00:00

  • Increased levels of serum leptin in the early stages of psychosis.

    abstract：BACKGROUND:Studies evaluating leptin levels in patients with first-episode psychoses (FEP) have been inconclusive, and apparently, the high levels of leptin reported in patients with schizophrenia may be associated with weight gain. The aim of this study was to evaluate leptin levels at the early stages of the disease ...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2019.01.006

    authors： Martorell L,Muntané G,Porta-López S,Moreno I,Ortega L,Montalvo I,Sanchez-Gistau V,Monseny R,Labad J,Vilella E

    更新日期：2019-04-01 00:00:00

  • Intranasal administration of nanostructured lipid carriers containing CNS acting drug: pharmacodynamic studies and estimation in blood and brain.

    abstract：:The present study was aimed to investigate and compare the efficacy of duloxetine (DLX) loaded nanostructured lipid carriers (NLC) with DLX solution pharmacodynamically following intranasal administration. The study was further conducted to estimate DLX concentration in brain and blood. DLX was administered to albino ...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2012.05.014

    authors： Alam MI,Baboota S,Ahuja A,Ali M,Ali J,Sahni JK

    更新日期：2012-09-01 00:00:00

  • Tolerability of the dexamethasone-corticotropin releasing hormone test in major depressive disorder.

    abstract：BACKGROUND:The dexamethasone-corticotropin releasing hormone (Dex-CRH) test may differentially predict which depressed patients will respond to antidepressant medication. However, a comprehensive analysis of the safety of this test in psychiatric patients has not previously been performed. METHODS:We conducted a poole...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2010.04.020

    authors： Dunlop BW,Betancourt Y,Binder EB,Heim C,Holsboer F,Ising M,McKenzie M,Mletzko T,Pfister H,Nemeroff CB,Craighead WE,Mayberg HS

    更新日期：2011-01-01 00:00:00

  • Life history of impulsive behavior: development and validation of a new questionnaire.

    abstract：:A self-report version of the Lifetime History of Impulsive Behaviors (LHIB) interview was developed and its psychometric properties examined. Initially, forty-two personality disordered and 20 control subjects completed both the interview (I) and self-report (Q53) versions of the LHIB along with other self-report meas...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2011.11.008

    authors： Coccaro EF,Schmidt-Kaplan CA

    更新日期：2012-03-01 00:00:00