Abstract:
INTRODUCTION:Investigations of gray matter changes in relation with auditory verbal hallucinations (AVH) have reported conflicting results. Assuming that alterations in gray matter might be related to certain symptoms in schizophrenia this study aimed to investigate changes in cortical thickness specific to AVH. It was hypothesized that schizophrenia patients suffering from persistent AVH would show significant differences in cortical thickness in regions involved in language-production and perception when compared to schizophrenia patients which had never experienced any hallucinations. METHODS:Using cortical thickness analysis the present study investigated ten schizophrenic patients suffering from AVH, ten non-hallucinating schizophrenic patients, and ten healthy control subjects. Anatomical data were acquired on a 3 T MRI system, transformed into standard space and cortically aligned to investigate local differences in whole brain cortical thickness between the two patient groups. Based on this comparison, brain regions with alterations specific for the patients with AVH were identified and then used as regions of interest to compare both patient groups to the healthy subjects respectively. RESULTS:Hallucinating patients showed gray matter reductions in the dominant hemisphere predominantly in sensory language areas relevant for speech processing. Increased cortical thickness was found in regions related to self-monitoring. CONCLUSIONS:Gray matter reductions in chronic schizophrenic patients may be the sequel of synaptic derangement or disease-related deregulation of language circuits. In order to clarify the ambiguous information processing additional demands might be put on cortical structures responsible for self-monitoring processes leading to changes in cortical thickness in the sense of neural plasticity.
journal_name
J Psychiatr Resjournal_title
Journal of psychiatric researchauthors
van Swam C,Federspiel A,Hubl D,Wiest R,Boesch C,Vermathen P,Kreis R,Strik W,Dierks Tdoi
10.1016/j.jpsychires.2012.03.016subject
Has Abstractpub_date
2012-08-01 00:00:00pages
1015-23issue
8eissn
0022-3956issn
1879-1379pii
S0022-3956(12)00098-2journal_volume
46pub_type
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