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Serotonin receptor HTR1A and HTR2C variants and personality traits in suicide attempters and controls.

Abstract：

INTRODUCTION:Serotonin has been extensively studied in relation to both personality features and suicidal behaviours. OBJECTIVE:In this study, we considered the association between the serotonin receptor 1A (HTR1A) and 2C (HTR2C) SNPs and personality traits, as measured by the Temperament and Character Inventory (TCI), in a sample of suicide patients and healthy volunteers. METHODS:The SNPs considered were, for HTR1A rs1423691, rs878567 and rs6295, and for HTR2C rs547536, rs2192372, rs6318, rs2428707, rs4272555 and rs1801412. The sample was composed of three groups: two German samples, consisting of a healthy control group of 289 subjects (42.6% males, mean age: 45.2+/-14.9) and a psychiatric patient group of 111 suicide attempters (38.7% males, mean age: 39.2+/-13.6), and an Italian sample, composed of 64 mood disorder patients (35.9% males, mean age: 43.0+/-14.8). In the German samples all the SNPs were investigated, while in the Italian sample only the HTR1A rs6295 and the HTR2C rs6318 SNPs were considered. RESULTS:Controlling for sex, age and educational level, single markers and haplotypes were not or only marginally associated with personality dimensions. CONCLUSIONS:Our study does not support the role of HTR1A and HTR2C gene variants on personality traits in both healthy volunteers and mood disorder patients.

journal_name

J Psychiatr Res

journal_title

Journal of psychiatric research

authors

Serretti A,Calati R,Giegling I,Hartmann AM,Möller HJ,Rujescu D

doi

10.1016/j.jpsychires.2008.06.005

subject

Has Abstract

pub_date

2009-02-01 00:00:00

pages

519-25

issue

5

eissn

0022-3956

issn

1879-1379

pii

S0022-3956(08)00138-6

journal_volume

43

pub_type

杂志文章

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