Abstract:
:Vitamin A and its derivatives, the retinoids, exert modulatory roles on central nervous system (CNS) function. However, the clinical use of vitamin A at moderate to high doses induces serious side effects, including dysfunctional brain metabolism and mood disorders. Then, we have investigated in this work the effects of vitamin A supplementation at 1000, 2500, 4500, or 9000IU/kg/day for 28 days on redox and bioenergetics parameters in adult rat frontal cortex. Additionally, we have measured caspase-3 and caspase-8 activities to analyze whether vitamin A supplementation as retinol palmitate induces neuronal death in such brain area. The levels of the pro-inflammatory cytokine TNF-alpha were also quantified. We have found increased rates of O(2)(-) production and increased levels of markers of oxidative insult in frontal cortex and also in mitochondrial membranes. Superoxide dismutase (SOD) enzyme activity was increased, and catalase (CAT) enzyme activity did not change in this experimental model. Surprisingly, we observed increased mitochondrial electron transfer chain (METC) activity. Caspase-3 and caspase-8 activities and TNF-alpha levels did not change in this experimental model. Finally, vitamin A supplementation did not induce depression in adult rats after 28 days of treatment. However, exploration in the center of an open field was decreased and time spent in freezing behavior was increased in vitamin A treated rats.
journal_name
J Psychiatr Resjournal_title
Journal of psychiatric researchauthors
De Oliveira MR,Oliveira MW,Behr GA,Moreira JCdoi
10.1016/j.jpsychires.2008.10.002subject
Has Abstractpub_date
2009-05-01 00:00:00pages
754-62issue
8eissn
0022-3956issn
1879-1379pii
S0022-3956(08)00231-8journal_volume
43pub_type
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pub_type: 杂志文章,meta分析,评审
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pub_type: 杂志文章
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pub_type: 杂志文章
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