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Association between methylation of the glucocorticoid receptor gene, childhood maltreatment, and clinical severity in borderline personality disorder.

Abstract：

:The hypothalamus-pituitary-adrenal axis (HPA) is essential in the regulation of stress responses. Increased methylation of the promoter region of the glucocorticoid receptor gene (NR3C1) has been described both in subjects with history of childhood trauma and in patients with Borderline Personality Disorder (BPD). However, no data on the possible association between a higher methylation of this gene and clinical severity is available. The aim of this study was to evaluate the association between NR3C1 methylation status, the history of childhood trauma, and current clinical severity in subjects with BPD. A sample of 281 subjects with BPD (diagnosed by SCID-II and DIB-R semi-structured diagnostic interviews) was recruited. Clinical variables included previous hospitalizations, self-injurious behavior, and self-reported history of childhood trauma. DNA was extracted from peripheral blood. The results indicated a significant positive correlation between NR3C1 methylation status and childhood maltreatment (specifically physical abuse). In addition, a positive correlation between methylation status and clinical severity (DIB-R total score and hospitalizations) was observed. These findings suggest that NR3C1 methylation in subjects with BPD may be associated not only with childhood trauma but also with clinical severity, adding new evidence to the involvement of gene-environment interactions in this disorder.

journal_name

J Psychiatr Res

journal_title

Journal of psychiatric research

authors

Martín-Blanco A,Ferrer M,Soler J,Salazar J,Vega D,Andión O,Sanchez-Mora C,Arranz MJ,Ribases M,Feliu-Soler A,Pérez V,Pascual JC

doi

10.1016/j.jpsychires.2014.06.011

subject

Has Abstract

pub_date

2014-10-01 00:00:00

pages

34-40

eissn

0022-3956

issn

1879-1379

pii

S0022-3956(14)00179-4

journal_volume

57

pub_type

杂志文章

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