当前位置： SCI文献检索 > JOURNAL OF PSYCHIATRIC RESEARCH期刊下所有文献 > Effects of ghrelin on psychopathology, sleep and secretion of cortisol and growth hormone in patients with major depression.

Effects of ghrelin on psychopathology, sleep and secretion of cortisol and growth hormone in patients with major depression.

Abstract：

:Ghrelin showed antidepressant-like effects in mice. Furthermore, ghrelin influences sleep and the activity of hypothalamic-pituitary-adrenal (HPA) and somatotropic axis in healthy humans as indicated by increased cortisol and growth hormone (GH) plasma levels. Both sleep and the activity of these endocrine axes are disturbed in depression. We therefore studied the impact of ghrelin on psychopathology, sleep and secretion of cortisol and GH in patients with major depression. Depressive symptoms as assessed by a validated self rating scale ('Befindlichkeits-Skala', [mental state scale]), secretion profiles of cortisol and GH and sleep-EEGs were determined in 14 unmedicated patients with major depression (7 women) twice, receiving 50 μg ghrelin or placebo at 22:00, 23:00, 00:00, and 01:00 hours. Overall, depressive symptoms did not change significantly after ghrelin administration (placebo: 37 ± 8; ghrelin: 33 ± 10, p = 0.178). However, there was an improvement at trend level in men (placebo: 36 ± 9 to ghrelin: 30 ± 9, p = 0.093) but not in women. In men, ghrelin was associated with less time awake (placebo: 149.0 ± 11.1; ghrelin: 88.0 ± 12.2 min, p = 0.029) and more non-REM sleep (placebo: 263.2 ± 24.1; ghrelin: 304.9 ± 14.1 min, p = 0.027), in women with less REM sleep (placebo: 108.6 ± 15.7; ghrelin: 74.1 ± 13.8 min, p = 0.031) and longer REM latency (placebo: 49.9 ± 6.5; ghrelin: 85.6 ± 14.1 min, p = 0.019). In both sexes, ghrelin caused strong transient increases of GH and cortisol. In conclusion, our study may provide some initial indication that ghrelin can exert antidepressant effects in patients with major depression. Ghrelin strongly affected sleep and secretion of GH and cortisol in a partly different way as previously reported in healthy subjects.

journal_name

J Psychiatr Res

journal_title

Journal of psychiatric research

authors

Kluge M,Schüssler P,Dresler M,Schmidt D,Yassouridis A,Uhr M,Steiger A

doi

10.1016/j.jpsychires.2010.09.002

subject

Has Abstract

pub_date

2011-03-01 00:00:00

pages

421-6

issue

3

eissn

0022-3956

issn

1879-1379

pii

S0022-3956(10)00262-1

journal_volume

45

pub_type

杂志文章,随机对照试验

相关文献

JOURNAL OF PSYCHIATRIC RESEARCH文献大全
  • Temperament and character of suicide attempters.

    abstract：:Temperamental features are strongly associated with suicidal behaviors both in general population and clinical samples. In the present study we considered the association between personality traits, measured by Temperament and Character Inventory (TCI), and suicidal behavior. We analyzed five samples: a German control...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2007.10.006

    authors： Calati R,Giegling I,Rujescu D,Hartmann AM,Möller HJ,De Ronchi D,Serretti A

    更新日期：2008-09-01 00:00:00

  • Measurement and predictors of resilience among community-dwelling older women.

    abstract：BACKGROUND:Resilience, the ability to adapt positively to adversity, may be an important factor in successful aging. However, the assessment and correlates of resilience in elderly individuals have not received adequate attention. METHOD:A total of 1395 community-dwelling women over age 60 who were participants at the...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2008.03.007

    authors： Lamond AJ,Depp CA,Allison M,Langer R,Reichstadt J,Moore DJ,Golshan S,Ganiats TG,Jeste DV

    更新日期：2008-12-01 00:00:00

  • Early life stress impacts dorsolateral prefrontal cortex functional connectivity in healthy adults: informing future studies of antidepressant treatments.

    abstract：:Exposure to early life stress (ELS) is strongly associated with poor treatment outcomes, particularly for trauma-associated disorders such as depression. Little research to date, however, has examined the potential effects of ELS on outcomes with newer treatments, such as repetitive transcranial magnetic stimulation (...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2014.01.014

    authors： Philip NS,Valentine TR,Sweet LH,Tyrka AR,Price LH,Carpenter LL

    更新日期：2014-05-01 00:00:00

  • Shorter and longer durations of sleep are associated with an increased twelve-month prevalence of psychiatric and substance use disorders: Findings from a nationally representative survey of US adults (NESARC-III).

    abstract：:The lack of comprehensive data on the association between psychiatric and substance use disorders and habitual sleep duration represents a major health information gap. This study examines the 12-month prevalence of mental disorders stratified by duration of sleep. Data were drawn from face-to-face interviews conducte...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2020.02.018

    authors： Geoffroy PA,Tebeka S,Blanco C,Dubertret C,Le Strat Y

    更新日期：2020-05-01 00:00:00

  • Platelet MAO activity in subtypes of alcoholics and controls in a homogenous population.

    abstract：:The level of platelet monoamine oxidase (MAO) activity has been found to vary between alcoholics and healthy controls and between subtypes of alcoholics, in different populations. This study measured the MAO activity in a group of 46 abstinent alcohol dependent subjects and 22 healthy non-alcoholic controls, male and ...

    journal_title：Journal of psychiatric research

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0022-3956(98)00047-8

    authors： Farren CK,Clare AW,Tipton KF,Dinan TG

    更新日期：1998-01-01 00:00:00

  • Alterations of microRNA-124 expression in peripheral blood mononuclear cells in pre- and post-treatment patients with major depressive disorder.

    abstract：:Recently, increasing evidence has indicated that dysfunction of microRNA-124 (miR-124) might be involved in the pathophysiology and treatment of major depressive disorder (MDD) in some animal models of depression. However, the role of miR-124 in MDD patients remains unclear. The objective of this study was to investig...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2016.03.015

    authors： He S,Liu X,Jiang K,Peng D,Hong W,Fang Y,Qian Y,Yu S,Li H

    更新日期：2016-07-01 00:00:00

  • The association of comorbid anxiety disorders with suicide attempts and suicidal ideation in outpatients with bipolar disorder.

    abstract：:Individuals with bipolar disorder are at increased risk for suicide attempts and completion. Although anxiety may be a modifiable suicide risk factor among bipolar patients, anxiety disorder comorbidity has not been highlighted as critical in identification of high-risk individuals nor has its treatment been integrate...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2006.08.004

    authors： Simon NM,Zalta AK,Otto MW,Ostacher MJ,Fischmann D,Chow CW,Thompson EH,Stevens JC,Demopulos CM,Nierenberg AA,Pollack MH

    更新日期：2007-04-01 00:00:00

  • Establishing moderators and biosignatures of antidepressant response in clinical care (EMBARC): Rationale and design.

    abstract：UNLABELLED:Remission rates for Major Depressive Disorder (MDD) are low and unpredictable for any given antidepressant. No biological or clinical marker has demonstrated sufficient ability to match individuals to efficacious treatment. Biosignatures developed from the systematic exploration of multiple biological marker...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.jpsychires.2016.03.001

    authors： Trivedi MH,McGrath PJ,Fava M,Parsey RV,Kurian BT,Phillips ML,Oquendo MA,Bruder G,Pizzagalli D,Toups M,Cooper C,Adams P,Weyandt S,Morris DW,Grannemann BD,Ogden RT,Buckner R,McInnis M,Kraemer HC,Petkova E,Carmody TJ

    更新日期：2016-07-01 00:00:00

  • Investigation of the expression of genes affecting cytomatrix active zone function in the amygdala in schizophrenia: effects of antipsychotic drugs.

    abstract：:The cytomatrix active zone (CAZ) is a specialized cellular structure regulating release of vesicles. We reported previously increased expression of three CAZ genes, piccolo, RIMS2 and RIMS3 in the amygdala in schizophrenia. This study determined the levels of gene and protein expression for components of the active zo...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2008.04.001

    authors： Weidenhofer J,Scott RJ,Tooney PA

    更新日期：2009-01-01 00:00:00

  • Birth weight and obstetric complications determine age at onset in first episode of psychosis.

    abstract：BACKGROUND:Earlier age at onset of psychosis (AOP) has been associated with poor social adjustment and clinical outcome. Genetic and environmental factors such as obstetric complications, parental history of psychosis, advanced paternal age at time of birth, low birth weight and gestational age, and use of drugs have b...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2015.03.018

    authors： Rubio-Abadal E,Ochoa S,Barajas A,Baños I,Dolz M,Sanchez B,Del Cacho N,Carlson J,Huerta-Ramos E,GENIPE Group.,Usall J

    更新日期：2015-06-01 00:00:00

  • Smoking status and its relationship to demographic and clinical characteristics in first episode psychosis.

    abstract：:Elevated rates of cigarette smoking are observed prior to the onset of psychosis and remain stable early in the illness. Cannabis use frequently co-occurs with cigarette smoking and is independently associated with distinct clinical outcomes. However, past research has not controlled for cannabis use in cigarette smok...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2016.10.022

    authors： Grossman M,Bowie CR,Lepage M,Malla AK,Joober R,Iyer SN

    更新日期：2017-02-01 00:00:00

  • Gender inequality and depression among medical students: A global meta-regression analysis.

    abstract：:Depression is a serious mental health problem with a high prevalence among medical students. It is unclear whether a gender disparity of depression exists in this population, and whether gender inequality influences depression estimates by gender. We conducted a systematic search for published systematic reviews or me...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.jpsychires.2019.01.013

    authors： Pacheco JPG,Silveira JB,Ferreira RPC,Lo K,Schineider JR,Giacomin HTA,Tam WWS

    更新日期：2019-04-01 00:00:00

  • Panic disorder: the role of the balance system.

    abstract：:Experimental evidences suggest that Panic Disorder (PD) is characterized by abnormalities in respiratory and vestibular functions. We studied balance system function in patients with PD and its relationships with CO(2) reactivity and clinical characteristics. Nineteen patients with PD with/without agoraphobia underwen...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/s0022-3956(01)00031-0

    authors： Perna G,Dario A,Caldirola D,Stefania B,Cesarani A,Bellodi L

    更新日期：2001-09-01 00:00:00

  • Epidemiology, implications and mechanisms underlying drug-induced weight gain in psychiatric patients.

    abstract：:Body weight gain frequently occurs during drug treatment of psychiatric disorders and is often accompanied by increased appetite or food craving. While occurrence and time course of this side effect are difficult to predict, it ultimately results in obesity and the morbidity associated therewith in a substantial part ...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章,评审

    doi：10.1016/s0022-3956(03)00018-9

    authors： Zimmermann U,Kraus T,Himmerich H,Schuld A,Pollmächer T

    更新日期：2003-05-01 00:00:00

  • Detecting psychotic major depression using psychiatric rating scales.

    abstract：OBJECTIVE:The aim of this study was to assess whether individual or clusters of psychiatric symptoms can differentiate patients with psychotic major depression (PMD) from those with nonpsychotic depression (NPMD). METHOD:Data were pooled from two studies investigating patients with moderate depression. A total of 129 ...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2005.07.003

    authors： Keller J,Gomez RG,Kenna HA,Poesner J,DeBattista C,Flores B,Schatzberg AF

    更新日期：2006-02-01 00:00:00

  • Cognitive task performance and symptoms contribute to personality abnormalities in first hospitalized schizophrenia.

    abstract：:Chronic schizophrenia patients have personality abnormalities and cognitive deficits that are associated with poor clinical, social, and vocational outcomes. Very few studies have examined relationships between personality and cognitive function, and chronic illness effects may have confounded those studies. In this s...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2014.03.022

    authors： Gurrera RJ,McCarley RW,Salisbury D

    更新日期：2014-08-01 00:00:00

  • Gender differences in depression: an ethological study of nonverbal behavior during interviews.

    abstract：:Previous studies of gender differences in the phenomenology of depression have focused mostly on symptoms as measured by self-report questionnaires or clinician-rated scales. In this study, we examined gender differences in the interpersonal behavior of depressed patients by using ethological techniques which involve ...

    journal_title：Journal of psychiatric research

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0022-3956(98)00064-8

    authors： Troisi A,Moles A

    更新日期：1999-05-01 00:00:00

  • Relationships between psychological distress, coping styles, and HPA axis reactivity in healthy adults.

    abstract：:Psychological distress and coping styles have been suggested to relate to altered function in the hypothalamic-pituitary-adrenal (HPA) axis, although there remains much to be understood about their relationships. High and low cortisol levels (or reactivity) both represent HPA axis dysfunction, with accumulated evidenc...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2010.02.007

    authors： Hori H,Ozeki Y,Teraishi T,Matsuo J,Kawamoto Y,Kinoshita Y,Suto S,Terada S,Higuchi T,Kunugi H

    更新日期：2010-10-01 00:00:00

  • Glutamate transporters: a key piece in the glutamate puzzle of major depressive disorder.

    abstract：:Glutamatergic therapies are emerging as the new path for the treatment of Major Depression Disorder. Recent reports reviewing the use of glutamate activity modulators in the treatment of resistant depression advocate the importance of understanding the alterations of the diverse components of this complex system in mo...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2013.04.007

    authors： Medina A,Burke S,Thompson RC,Bunney W Jr,Myers RM,Schatzberg A,Akil H,Watson SJ

    更新日期：2013-09-01 00:00:00

  • Working memory dysfunction in obsessive-compulsive disorder: a neuropsychological and functional MRI study.

    abstract：:Previous neuropsychological studies indicate that OCD subtypes such as checking rituals might be associated with a working memory deficit. On the other hand, functional neuroimaging studies found functional abnormalities of the frontal cortex and subcortical structures in OCD. Combined with functional imaging method, ...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2008.10.013

    authors： Nakao T,Nakagawa A,Nakatani E,Nabeyama M,Sanematsu H,Yoshiura T,Togao O,Tomita M,Masuda Y,Yoshioka K,Kuroki T,Kanba S

    更新日期：2009-05-01 00:00:00

  • The familial transmission of primary major depressive disorder.

    abstract：:This is a study of the familial transmission of Primary Major Depressive Disorder in the families of 235 probands with this disorder ascertained as part of the NIMH-CRB Collaborative Depression Program. Eight hundred and twenty-six interviewed first degree relatives and 109 spouses are included. Research Diagnostic Cr...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/0022-3956(87)90112-9

    authors： Reich T,Van Eerdewegh P,Rice J,Mullaney J,Endicott J,Klerman GL

    更新日期：1987-01-01 00:00:00

  • Relationship between ethnicity and sleep patterns in normal controls: implications for psychopathology and treatment.

    abstract：:The purpose of the study was to examine ethnic influences on sleep regulation. Seventy-three normal volunteers from four ethnic groups (17 African-Americans, 10 Asians, 30 Caucasians and 16 Hispanics) were studied for two consecutive nights with sleep polysomnography recordings in the laboratory. The subjects were in ...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/s0022-3956(99)00019-9

    authors： Rao U,Poland RE,Lutchmansingh P,Ott GE,McCracken JT,Lin KM

    更新日期：1999-09-01 00:00:00

  • ABCB1 gene polymorphisms and violent suicide attempt among survivors.

    abstract：INTRODUCTION:Those suicide attempters that choose violent methods dramatically diminish the possibility of survival. Completed suicide using violent means, which is common among first-time suicide attempters, was recently found to be more likely among T allele carriers in the three most common ABCB1 SNPs, encoding for ...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2014.12.005

    authors： Peñas-Lledó E,Guillaume S,Delgado A,Naranjo ME,Jaussent I,LLerena A,Courtet P

    更新日期：2015-02-01 00:00:00

  • Temporal sequencing of nicotine dependence and bipolar disorder in the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC).

    abstract：:Bipolar disorder (BD) and nicotine dependence (ND) often co-occur. However, the mechanisms underlying this association remain unclear. We aimed to examine, for the first time in a national and representative sample, the magnitude and direction of the temporal relationship between BD and ND; and to compare, among indiv...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2013.03.012

    authors： Martínez-Ortega JM,Goldstein BI,Gutiérrez-Rojas L,Sala R,Wang S,Blanco C

    更新日期：2013-07-01 00:00:00

  • FDG-PET mapping the brain substrates of visuo-constructive processing in Alzheimer's disease.

    abstract：:The anatomical basis of visuo-constructive impairment in AD is widely unexplored. FDG-PET can be used to determine functional neuronal networks underlying specific cognitive performance in the human brain. In the present study, we determined the pattern of cortical metabolism that was associated with visuo-constructiv...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2009.09.012

    authors： Förster S,Teipel S,Zach C,Rominger A,Cumming P,Fougere Cl,Yakushev I,Haslbeck M,Hampel H,Bartenstein P,Bürger K

    更新日期：2010-05-01 00:00:00

  • A twin study of amino acid concentrations in cerebrospinal fluid.

    abstract：:The concentrations of amino acids in the cerebrospinal fluid (CSF) were measured in pairs of healthy mono- and dizygotic twins. Intraclass correlations were calculated. Genetic and cultural heritabilities were estimated using a path analytical model. CSF levels of glycine, tyrosine and arginine were shown to be influe...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/0022-3956(88)90028-3

    authors： Hagenfeldt L,Oxenstierna G,Alfredsson G,Edman G,Iselius L,Sedvall G

    更新日期：1988-01-01 00:00:00

  • Measuring resilience in women experiencing infertility using the CD-RISC: examining infertility-related stress, general distress, and coping styles.

    abstract：:Psychological morbidity concurrent with fertility problems has been the focus of substantial scientific inquiry. However, researchers have largely overlooked psychological resilience within this population. This study explored the associations between resilience, infertility-related and general distress, and coping be...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jpsychires.2009.06.007

    authors： Sexton MB,Byrd MR,von Kluge S

    更新日期：2010-03-01 00:00:00

  • From phone use to speeding and driving under influence: Identifying clusters of driving risk behaviors as an opportunity for targeted interventions.

    abstract：:Identifying the profile of risky behaviors among drivers is central to propose effective interventions. Due to the multidimensional and overlapping aspects of risky driving behaviors, cluster analysis can provide additional insights in order to identify specific subgroups of risk. This study aimed to identify clusters...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2020.11.025

    authors： Rabelo-da-Ponte FD,Scherer JN,Roglio V,Borges EN,Galland F,Sousa T,Passos IC,von Diemen L,Kessler F,Pechansky F

    更新日期：2020-11-12 00:00:00

  • 1H MRSI of middle frontal gyrus in pediatric ADHD.

    abstract：:Neuroimaging studies in multiple modalities have implicated the left or right dorsolateral prefrontal cortex (here, middle frontal gyrus) in attentional functions, in ADHD, and in dopamine agonist treatment of ADHD. The far lateral location of this cortex in the brain, however, has made it difficult to study with magn...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2012.11.011

    authors： Tafazoli S,O'Neill J,Bejjani A,Ly R,Salamon N,McCracken JT,Alger JR,Levitt JG

    更新日期：2013-04-01 00:00:00

  • Differential effects of fluoxetine and imipramine on the phosphorylation of the transcription factor CREB and cell-viability.

    abstract：:It has been shown that antidepressants increase the expression of CREB (cAMP-response-element-binding-protein) and BDNF (brain derived neurotrophic factor) in vivo. Apparently inconsistent to these survival-promoting properties for many years antidepressants are known to induce apoptosis in various cell types in vitro...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/s0022-3956(02)00061-4

    authors： Koch JM,Kell S,Aldenhoff JB

    更新日期：2003-01-01 00:00:00