当前位置： SCI文献检索 > JOURNAL OF PSYCHIATRIC RESEARCH期刊下所有文献 > Working memory dysfunction in obsessive-compulsive disorder: a neuropsychological and functional MRI study.

Working memory dysfunction in obsessive-compulsive disorder: a neuropsychological and functional MRI study.

Abstract：

:Previous neuropsychological studies indicate that OCD subtypes such as checking rituals might be associated with a working memory deficit. On the other hand, functional neuroimaging studies found functional abnormalities of the frontal cortex and subcortical structures in OCD. Combined with functional imaging method, we applied neuropsychological batteries to demonstrate a working memory deficit in OCD by comparison with normal controls. In addition, working memory and brain activation were further examined with symptom-based analysis. Forty patients with OCD and 25 normal controls were examined using neuropsychological tests including the WAIS-R, WCST, WMS-R, and R-OCFT and functional MRI (fMRI) during the N-back task including 0- and 2-back task. On fMRI, the brain regions activated during the performance and the differences in the activation between patients and controls were identified. Additional analyses of severity and subtypes were conducted by using Y-BOCS severity score, symptom-checklist and Leckman's four-factor model, respectively. On the neuropsychological tests, the OCD patients had significantly lower scores on the delayed recall section of the WMS-R and the immediate recall section of the R-OCFT compared to the controls. On fMRI, the patients showed greater activation in the right dorsolateral prefrontal cortex (DLPFC), left superior temporal gyrus (STG), left insula, and cuneus during two-back task compared to the controls. Right orbitofrontal cortex activity showed a significant positive correlation with Y-BOCS scores in OCD. Furthermore, patients with obsessions/checking rituals (n=10) showed severer memory deficits and decreased activity in the postcentral gyrus than patients with cleanliness/washing rituals (n=14). In conclusion, we found neuropsychological dysfunction and brain abnormalities in OCD. Furthermore, our results suggested that symptom severity and symptom subtype such as obsessions/checking might affect neuropsychological dysfunction and related brain activities.

journal_name

J Psychiatr Res

journal_title

Journal of psychiatric research

authors

Nakao T,Nakagawa A,Nakatani E,Nabeyama M,Sanematsu H,Yoshiura T,Togao O,Tomita M,Masuda Y,Yoshioka K,Kuroki T,Kanba S

doi

10.1016/j.jpsychires.2008.10.013

subject

Has Abstract

pub_date

2009-05-01 00:00:00

pages

784-91

issue

eissn

0022-3956

issn

1879-1379

pii

S0022-3956(08)00245-8

journal_volume

pub_type

杂志文章

在线工具

Working memory dysfunction in obsessive-compulsive disorder: a neuropsychological and functional MRI study.