Abstract：
:Drug treatment of panic disorder with benzodiazepines and antidepressants has been established as efficacious in the short-term (6-8 weeks). The efficacy of medications during long-term (i.e., continuous) treatment has not often been addressed and a review of the evidence is presented. Most data exists for the long-term effectiveness of benzodiazepines. Experience with the triazolobenzodiazepine, alprazolam, is reviewed together with some other high potency drugs, e.g., clonazepam. Tricyclic antidepressants are also effective in the long-term treatment of panic and the relevant studies are presented. Long-term efficacy for monoamine oxidase inhibitors is not as clearly established. The issue of relapse following drug withdrawal is addressed and some strategies for patient management in long-term therapy are discussed.
journal_name
J Psychiatr Resjournal_title
Journal of psychiatric researchauthors
Burrows GD,Judd FK,Norman TRdoi
10.1016/0022-3956(93)90022-tsubject
Has Abstractpub_date
1993-01-01 00:00:00pages
111-25eissn
0022-3956issn
1879-1379journal_volume
27 Suppl 1pub_type
杂志文章,评审abstract：:Negative symptoms are the most resilient manifestations in schizophrenia. An imbalance in dopamine and glutamate pathways has been proposed for the emergence of these symptoms. SP1, SP3 and SP4 transcription factors regulate genes in these pathways, suggesting a possible involvement in negative symptoms. In this study...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2013.03.004
更新日期：2013-07-01 00:00:00
abstract：:This study explored whether cerebral metabolic changes seen in treatment resistant and rapid cycling bipolar depression inpatients are also found in an outpatient sample not specifically selected for treatment resistance or rapid cycling. We assessed 15 depressed outpatients with bipolar disorder (six type I and nine ...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2008.04.015
更新日期：2009-01-01 00:00:00
abstract：:The anterior cingulate cortex (ACC) plays a major role in modulating executive control of attention. Here, 15 medication-nai ve patients with attention deficit/hyperactivity disorder (ADHD) and 10 carefully matched healthy controls were studied with 2D (1)H-magnetic resonance spectroscopic imaging (MRSI) of the ACC [B...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2007.06.006
更新日期：2008-06-01 00:00:00
abstract：:Cognitive deficits, which are core manifestations in schizophrenia and exhibit a limited response to antipsychotic treatment, contribute to poor treatment outcomes and functional disability. Evidence on the effect of aerobic walking (AW) and exercise intensity on cognitive function in patients with schizophrenia is la...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2020.12.062
更新日期：2020-12-24 00:00:00
abstract：:Analysis of the distribution of diagnoses in families (segregation analysis) has not, so far, advanced us toward the goal of resolving the inheritance of the major psychiatric disorders. Recent advances in genetics, particularly the development of new molecular genetic linkage methods, have made it, at least theoretic...
journal_title：Journal of psychiatric research
pub_type： 杂志文章,评审
doi：10.1016/0022-3956(87)90103-8
更新日期：1987-01-01 00:00:00
abstract：:Physicians who prescribe benzodiazepines often are asked by their patients if these drugs might be addicting or have potential for abuse. Clarifying these concepts is difficult because of numerous "gray areas" of drug use and confusion over medical criteria for such terms as "addiction", "dependence", and "tolerance"....
journal_title：Journal of psychiatric research
pub_type： 杂志文章,评审
doi：10.1016/0022-3956(90)90036-p
更新日期：1990-01-01 00:00:00
abstract：:Previous reports suggest that massive hormonal changes that accompany the peripartum period may trigger perinatal depression. We investigated the relationship between magnitude of change and total level of estrogen and progesterone and grade of peripartal depression and depressive symptoms. One hundred and ninety two ...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2006.09.002
更新日期：2007-04-01 00:00:00
abstract：BACKGROUND:Patients with posttraumatic stress disorder (PTSD) are at increased risk for adverse consequences from comorbid medical conditions. Nonadherence to medications prescribed to treat those comorbid conditions may help explain this increased risk. We sought to determine the association between PTSD and medicatio...
journal_title：Journal of psychiatric research
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.jpsychires.2018.02.013
更新日期：2018-07-01 00:00:00
abstract：:Prenatal COVID-19 infection is anticipated by the U.S. Centers for Disease Control to affect fetal development similarly to other common respiratory coronaviruses through effects of the maternal inflammatory response on the fetus and placenta. Plasma choline levels were measured at 16 weeks gestation in 43 mothers who...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2020.05.019
更新日期：2020-09-01 00:00:00
abstract：:The results of several epidemiological studies and clinical trials investigating the effects of n-3 polyunsaturated fatty acids (PUFAs) on antenatal and postnatal depression remain controversial. We investigated the possible association of dietary intake of fish and n-3 PUFAs with the risks of maternal and paternal ps...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2017.11.013
更新日期：2018-03-01 00:00:00
abstract：:The post-partum period is a time of extreme vulnerability for a whole spectrum of psychiatric disorders. Delivery may be considered an important risk factor in genetically susceptible women. Five hundred and eight SNPs in 44 genes at candidate pathways putatively related to mood changes after delivery were genotyped i...
journal_title：Journal of psychiatric research
pub_type： 杂志文章,多中心研究
doi：10.1016/j.jpsychires.2009.12.012
更新日期：2010-08-01 00:00:00
abstract：:Few studies have tracked the long-term mental health outcomes following major disaster. We sought to document the trajectories of depressive symptoms and post-traumatic stress symptoms (PTSS) in the aftermath of the 2011 Great East Japan earthquake and tsunami. A cohort of community-dwelling older adults were followed...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2020.08.016
更新日期：2020-08-23 00:00:00
abstract：UNLABELLED:Remission rates for Major Depressive Disorder (MDD) are low and unpredictable for any given antidepressant. No biological or clinical marker has demonstrated sufficient ability to match individuals to efficacious treatment. Biosignatures developed from the systematic exploration of multiple biological marker...
journal_title：Journal of psychiatric research
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.jpsychires.2016.03.001
更新日期：2016-07-01 00:00:00
abstract：:The objective of this report is to determine whether those patients with panic disorder who have current major depression disorder (MDD) differ from those who do not in terms of demographics, comorbid disorders, severity of illness, nature of symptoms of panic attacks and psychosocial functioning. The sample consisted...
journal_title：Journal of psychiatric research
pub_type： 杂志文章,多中心研究
doi：10.1016/0022-3956(93)90015-t
更新日期：1993-01-01 00:00:00
abstract：:Recent evidence suggests that peripheral markers related to oxidative stress, inflammation and neurotrophins may be altered during mood episodes in bipolar disorder. These can be seen as proxies of peripheral toxicity or markers of illness activity. Here we report an en bloc assessment of a set of previously described...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2010.05.015
更新日期：2011-02-01 00:00:00
abstract：:The neurogenesis hypothesis of major depression has two main facets. One states that the illness results from decreased neurogenesis while the other claims that the very functioning of antidepressants depends on increased neurogenesis. In order to verify the latter, we have used cyclin D2 knockout mice (cD2 KO mice), ...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2014.05.009
更新日期：2014-09-01 00:00:00
abstract：:There is a body of evidence suggesting that BDNF is involved in bipolar disorder (BD) pathogenesis. Intracerebroventricular (ICV) injection of ouabain (OUA), a specific Na(+)/K(+) ATPase inhibitor, induces hyperlocomotion in rats, and has been used as an animal model of mania. The present study aims to investigate the...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2009.11.002
更新日期：2010-06-01 00:00:00
abstract：:Early discharge or reduced length of stay for inpatient psychiatric patients is related to increased readmission rates and worse clinical outcomes including increased risk for suicide. Trajectories of mental illness outcomes have been identified as an important method for predicting the optimal length of stay but the ...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2020.07.001
更新日期：2020-11-01 00:00:00
abstract：:Neural cell adhesion molecule (N-CAM) is a cell recognition molecule, four major isoforms (180, 140, 120, and 105-115 kDa) of which are present in brain. N-CAM has several roles in cellular organization and CNS development. Previously we have found an elevation in CSF N-CAM 120 kDa in the CSF of patients with schizoph...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/s0022-3956(99)00026-6
更新日期：2000-01-01 00:00:00
abstract：:Smooth pursuit eye movement (SPEM) performance has been linked to nonvoluntary attentional processes. Amphetamine is a psychotropic drug with documented effects on attentional performance. In order to evaluate the relationship between SPEM performance and amphetamine's attentional effects, SPEM performance was measure...
journal_title：Journal of psychiatric research
pub_type： 临床试验,杂志文章
doi：10.1016/0022-3956(87)90013-6
更新日期：1987-01-01 00:00:00
abstract：:Benzodiazepine hypnotics increase NREM sleep and alter its EEG by reducing delta (0.3-3 Hz) and increasing sigma (12-15 Hz) and beta (15-23 Hz) activity. We tested whether the nonbenzodiazepine hypnotic, zolpidem (10 mg), produced the same pattern of sleep and EEG changes as two "classical" benzodiazepines, triazolam ...
journal_title：Journal of psychiatric research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0022-3956(00)00038-8
更新日期：2000-11-01 00:00:00
abstract：:This study investigated the changes of the neuropsychological functions over a 4-month period of treatment in patients with obsessive-compulsive disorder (OCD). Thirty-nine OCD patients and 31 healthy controls were evaluated with neuropsychological and clinical tests. The same tests were readministered 4-months after ...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/s0022-3956(02)00017-1
更新日期：2002-07-01 00:00:00
abstract：:The anatomical basis of visuo-constructive impairment in AD is widely unexplored. FDG-PET can be used to determine functional neuronal networks underlying specific cognitive performance in the human brain. In the present study, we determined the pattern of cortical metabolism that was associated with visuo-constructiv...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2009.09.012
更新日期：2010-05-01 00:00:00
abstract：:Gender Identity Disorder (GID) is characterized by a strong and persistent cross-gender identification that affects different aspects of behavior. Brain-derived neurotrophic factor (BDNF) plays a critical role in neurodevelopment and neuroplasticity. Altered BDNF-signaling is thought to contribute to the pathogenesis ...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2013.04.012
更新日期：2013-10-01 00:00:00
abstract：:Vitamin A and its derivatives, the retinoids, exert modulatory roles on central nervous system (CNS) function. However, the clinical use of vitamin A at moderate to high doses induces serious side effects, including dysfunctional brain metabolism and mood disorders. Then, we have investigated in this work the effects ...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2008.10.002
更新日期：2009-05-01 00:00:00
abstract：:Consistent evidence indicates that exercise improves cognition and mood, with preliminary evidence suggesting that brain-derived neurotrophic factor (BDNF) may mediate these effects. The aim of the current meta-analysis was to provide an estimate of the strength of the association between exercise and increased BDNF l...
journal_title：Journal of psychiatric research
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.jpsychires.2014.10.003
更新日期：2015-01-01 00:00:00
abstract：BACKGROUND:The Glial cell-line derived neurotrophic factor (GDNF) is part of the TGF-β superfamily and is abundantly expressed in the central nervous system. Changes in GDNF homeostasis have been reported in affective disorders. AIM:To assess serum GDNF concentration in elderly subjects with late-life depression, befo...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2011.09.007
更新日期：2012-01-01 00:00:00
abstract：BACKGROUND:Sluggish cognitive tempo (SCT) is associated with-but distinct from-attention-deficit/hyperactivity disorder (ADHD). This study examined SCT rates in adult outpatients seeking an ADHD assessment, differences in rates based on ADHD status, impact of assessment method (i.e., reporting source, symptom count, an...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2020.09.013
更新日期：2020-12-01 00:00:00
abstract：:Aggressive behavior and violence in psychiatric patients have often been quoted to justify more restrictive settings in psychiatric facilities. However, the effects of open vs. locked door policies on aggressive incidents remain unclear. This study had a naturalistic observational design and analyzed the occurrence of...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2017.08.017
更新日期：2017-12-01 00:00:00
abstract：:People living with mental illness often experience poor sleep quality compared to the general population. Poor sleep quality exacerbates symptoms of mental illness and contributes to increased physical comorbidities. Exercise has been shown to be an effective non-pharmacological treatment for managing poor sleep in th...
journal_title：Journal of psychiatric research
pub_type： 杂志文章,meta分析
doi：10.1016/j.jpsychires.2018.11.004
更新日期：2019-02-01 00:00:00
