Abstract：
:Previous reports suggest that massive hormonal changes that accompany the peripartum period may trigger perinatal depression. We investigated the relationship between magnitude of change and total level of estrogen and progesterone and grade of peripartal depression and depressive symptoms. One hundred and ninety two women were assessed in the 38th week of pregnancy (SDS scores), peripartum period (DSM-III-R diagnosis (n=105); SDS scores) and 6 months postpartum (EPDS; n=89) regarding diagnosis of depression, self-ratings of depressive symptoms and levels of estrogen and progesterone. The comparison of three diagnostic groups (lifetime major depressive disorder MDD (N=7), MDD at birth (N=12), healthy controls (N=70) showed that there were no differences in the magnitude of decline of estrogen and progesterone from day 1 to day 3 after birth . With respect to total levels of estrogen and progesterone, estrogen on day 3 was significantly higher [F(2,92)=6.6, p<0.05] in women with current MDD than in those with lifetime MDD or normal controls. Depression scores were significantly higher at the end of pregnancy (12.6% self-identified as depressed) than in postpartum period (5.8% day 3 p<.0004; 9.2% day 5 p<.008), whereas 13.3% of women received a DSM-III -R diagnosis for MDD 5 days postpartum. The results were in contrast to the current hypotheses of estrogen withdrawal or hypogonadal levels as an etiological factor for peripartum depression. But a limitation of the actual study is the low number of subjects with depression; therefore the current non-significant findings should be interpreted with great caution.
journal_name
J Psychiatr Resjournal_title
Journal of psychiatric researchauthors
Klier CM,Muzik M,Dervic K,Mossaheb N,Benesch T,Ulm B,Zeller Mdoi
10.1016/j.jpsychires.2006.09.002subject
Has Abstractpub_date
2007-04-01 00:00:00pages
273-9issue
3-4eissn
0022-3956issn
1879-1379pii
S0022-3956(06)00182-8journal_volume
41pub_type
杂志文章abstract：:There are strong links between childhood trauma and the risk of violence (Ford et al., 2007). Despite evidence that people with psychotic disorders are at a higher risk of violence than the general population (Witt et al., 2013) there have been few studies that have examined the trauma-violence link in this population...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
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journal_title：Journal of psychiatric research
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journal_title：Journal of psychiatric research
pub_type： 杂志文章,随机对照试验
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abstract：:Sexual child abuse is one of the most destructive events for child development. One possible approach to avert it is the preventive treatment of individuals with a sexual interest in children. The aim of the current eye tracking study was to compare people with a self-reported sexual interest in children who participa...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
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abstract：OBJECTIVES:To determine the prevalence, age of onset, severity, associated disability, and treatment of major depression among United States ethnic groups, national survey data were analyzed. METHODS:National probability samples of US household residents aged 18-years and older (n=14,710) participated. The main outcom...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
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abstract：:The present work developed a virtual reality (VR) counterconditioning procedure (VRCP), and investigated its efficacy in treatment of cue-induced craving in individuals with methamphetamine (METH) dependence. In study 1, thirty-one patients diagnosed with METH dependence received VRCP, while twenty-nine METH-dependent...
journal_title：Journal of psychiatric research
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journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/0022-3956(82)90042-5
更新日期：1982-01-01 00:00:00
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journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2013.01.015
更新日期：2013-06-01 00:00:00
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journal_title：Journal of psychiatric research
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journal_title：Journal of psychiatric research
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更新日期：2011-02-01 00:00:00
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journal_title：Journal of psychiatric research
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pub_type： 杂志文章
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journal_title：Journal of psychiatric research
pub_type： 杂志文章
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更新日期：2014-05-01 00:00:00
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journal_title：Journal of psychiatric research
pub_type： 杂志文章
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更新日期：1988-01-01 00:00:00
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journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2007.11.009
更新日期：2008-10-01 00:00:00
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journal_title：Journal of psychiatric research
pub_type： 杂志文章,meta分析
doi：10.1016/j.jpsychires.2013.08.015
更新日期：2013-12-01 00:00:00
abstract：:The first genome-wide association study of human memory identified an association between a common T/C polymorphism of the KIBRA gene (rs17070145) and episodic memory performance in normal individuals; subsequent studies have implicated the same polymorphism in Alzheimer's disease. Since impaired neurocognitive perfor...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2010.01.012
更新日期：2010-09-01 00:00:00
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journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2014.08.013
更新日期：2015-01-01 00:00:00
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journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2018.03.008
更新日期：2018-07-01 00:00:00
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journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2019.01.015
更新日期：2019-04-01 00:00:00
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journal_title：Journal of psychiatric research
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.jpsychires.2017.07.020
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journal_title：Journal of psychiatric research
pub_type： 临床试验,杂志文章
doi：10.1016/s0022-3956(98)00047-8
更新日期：1998-01-01 00:00:00
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journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/0022-3956(85)90076-7
更新日期：1985-01-01 00:00:00
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journal_title：Journal of psychiatric research
pub_type： 杂志文章
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更新日期：2020-09-01 00:00:00
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journal_title：Journal of psychiatric research
pub_type： 杂志文章
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更新日期：2020-02-01 00:00:00
abstract：:Psychological distress and coping styles have been suggested to relate to altered function in the hypothalamic-pituitary-adrenal (HPA) axis, although there remains much to be understood about their relationships. High and low cortisol levels (or reactivity) both represent HPA axis dysfunction, with accumulated evidenc...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2010.02.007
更新日期：2010-10-01 00:00:00
abstract：OBJECTIVES:The DEX/CRH test has been proposed to be suitable as a biomarker for the prediction of treatment response in depression. METHODS:We performed the DEX/CRH test in 10 severely depressed male patients with melancholic features before initiation of antidepressant treatment with 20 mg fluoxetine. RESULTS:We fou...
journal_title：Journal of psychiatric research
pub_type： 临床试验,杂志文章
doi：10.1016/j.jpsychires.2010.04.010
更新日期：2010-12-01 00:00:00
abstract：BACKGROUND:Transcutaneous electrical acupoint stimulation (TEAS) is thought to have potential to treat obsessive-compulsive disorder (OCD). OBJECTIVE:The purpose of this study was to determine whether adding TEAS to cognitive behavioral therapy (CBT) and clomipramine would improve the efficacy of these conventional tr...
journal_title：Journal of psychiatric research
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.jpsychires.2016.05.015
更新日期：2016-09-01 00:00:00
abstract：:Early score fluctuation in double-blind, placebo-controlled studies may affect the reliability of the baseline measurement and adversely affect the eventual study outcome. We examined the effect of early score fluctuation during a 2-week double-blind placebo lead-in period in a phase II, double-blind, placebo-controll...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2019.11.014
更新日期：2020-02-01 00:00:00
abstract：AIM:The goal of this retrospective cohort study was to analyze the relationship between induced abortion and the incidence of depression, anxiety disorder, adjustment disorder, and somatoform disorder in Germany. METHODS:Women who had undergone induced abortions for the first time in 281 gynecological practices in Ger...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2019.04.022
更新日期：2019-07-01 00:00:00
