Circulating Glial-derived neurotrophic factor is reduced in late-life depression.

Abstract:

BACKGROUND:The Glial cell-line derived neurotrophic factor (GDNF) is part of the TGF-β superfamily and is abundantly expressed in the central nervous system. Changes in GDNF homeostasis have been reported in affective disorders. AIM:To assess serum GDNF concentration in elderly subjects with late-life depression, before antidepressant treatment, as compared to healthy elderly controls. METHODS:Thirty-four elderly subjects with major depression and 37 age and gender-matched healthy elderly controls were included in this study. Diagnosis of major depression was ascertained by the SCID interview for DSM-IV and the severity of depressive symptoms was assessed by the Hamilton Depression Rating Scale (HDRS-21). Serum GDNF concentration were determined by sandwich ELISA. RESULTS:Patients with major depression showed a significant reduction in GDNF levels as compared to healthy elderly controls (p < 0.001). Also, GDNF level was negatively correlated with HDRS-21 scores (r = -0.343, p = 0.003). DISCUSSION:Our data provide evidence that GDNF may be a state marker of depressive episode in older adults. Changes in the homeostatic control of GDNF production may be a target to development of new antidepressant strategies.

journal_name

J Psychiatr Res

authors

Diniz BS,Teixeira AL,Miranda AS,Talib LL,Gattaz WF,Forlenza OV

doi

10.1016/j.jpsychires.2011.09.007

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

135-9

issue

1

eissn

0022-3956

issn

1879-1379

pii

S0022-3956(11)00193-2

journal_volume

46

pub_type

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