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Cognitive MR spectroscopy of anterior cingulate cortex in ADHD: elevated choline signal correlates with slowed hit reaction times.

Abstract：

:The anterior cingulate cortex (ACC) plays a major role in modulating executive control of attention. Here, 15 medication-nai ve patients with attention deficit/hyperactivity disorder (ADHD) and 10 carefully matched healthy controls were studied with 2D (1)H-magnetic resonance spectroscopic imaging (MRSI) of the ACC [Brodmann areas 24b'-c' and 32']. Attentional skills were assessed using the identical pairs version of the continuous performance task (CPT-IP). Analysis of regional brain spectra revealed a significantly increased signal of choline-containing compounds (Ch) in the ACC of ADHD patients (p<0.05). Across and within groups, the Ch signal showed high correlations with slowed hit reaction times on the CPT-IP. No group differences in N-acetyl-aspartate (NAA) and creatine (tCr) were detectable. The combination of performance deficits and elevated Ch levels in the ACC supports the hypothesis that subtle structural abnormalities underlie the functional alterations in ACC activation previously observed in ADHD patients.

journal_name

J Psychiatr Res

journal_title

Journal of psychiatric research

authors

Colla M,Ende G,Alm B,Deuschle M,Heuser I,Kronenberg G

doi

10.1016/j.jpsychires.2007.06.006

subject

Has Abstract

pub_date

2008-06-01 00:00:00

pages

587-95

issue

7

eissn

0022-3956

issn

1879-1379

pii

S0022-3956(07)00102-1

journal_volume

42

pub_type

杂志文章

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