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Dopamine-system genes, childhood abuse, and clinical manifestations in women with Bulimia-Spectrum Disorders.

Abstract：

OBJECTIVE:We explored interaction effects involving polymorphisms of targeted dopamine system genes and selected forms of childhood abuse (sexual, physical and emotional) acting upon severity of binge-eating and psychopathological symptoms in women with Bulimia-Spectrum Disorders (BSDs). METHODS:Women diagnosed with a BSD (n = 216) were assessed for childhood traumata, eating-disorder (ED) symptoms, and selected psychopathological features (sensation seeking, impulsivity, compulsivity and affective instability), and then provided blood samples for genotyping of main polymorphisms of dopamine-2 receptor (DRD2), dopamine transporter (DAT1) and catechol o-methyltransferase (COMT) genes. RESULTS:Sensation Seeking was elevated in carriers of the low-function allele of the DRD2 Taq1A polymorphism who also reported childhood sexual abuse, relative to that in individuals showing other combinations of alleles and abuse exposures. In addition, carriers of a low-function allele of COMT scored higher on compulsivity, lower on impulsivity, and marginally lower on frequency of binge-eating than did individuals in whom the allele was absent. DISCUSSION:Our results suggest that genes acting within the dopamine system may contribute, either directly or indirectly (i.e., in interaction with traumatic childhood experiences), to variations in the presentation of comorbid traits and, possibly, of bulimic symptoms.

journal_name

J Psychiatr Res

journal_title

Journal of psychiatric research

authors

Groleau P,Steiger H,Joober R,Bruce KR,Israel M,Badawi G,Zeramdini N,Sycz L

doi

10.1016/j.jpsychires.2012.05.018

subject

Has Abstract

pub_date

2012-09-01 00:00:00

pages

1139-45

issue

9

eissn

0022-3956

issn

1879-1379

pii

S0022-3956(12)00181-1

journal_volume

46

pub_type

杂志文章

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