Tricyclic therapy of the DSM-III anxiety disorders: a review with implications for further research.


:Existing data suggests dramatic efficacy for all tested tricyclics in disorders involving spontaneous panic attacks; moderate efficacy for clomipramine but not other tricyclics in obsessive-compulsive patients; possible, but as yet not well established, tricyclic efficacy in generalized anxiety; and lack of efficacy in simple phobias. Further studies in all DSM-III Anxiety Disorders are both warranted and required to answer the nosological, pathophysiological and treatment questions raised by these findings.


J Psychiatr Res


Liebowitz MR,Fyer AJ,Gorman JM,Campeas RB,Sandberg DP,Hollander E,Papp LA,Klein DF




Has Abstract


1988-01-01 00:00:00








22 Suppl 1


  • Psychopathology factors in first-episode affective and non-affective psychotic disorders.

    abstract:BACKGROUND:Since the onset, prevalence, and course of specific psychopathological features rarely have been analyzed simultaneously from the start of dissimilar psychotic illnesses, we compared symptom-clusters in first-episode DSM-IV affective and non-affective psychotic disorders. METHODS:Subjects (N=377) from the M...

    journal_title:Journal of psychiatric research

    pub_type: 杂志文章


    authors: Salvatore P,Khalsa HM,Hennen J,Tohen M,Yurgelun-Todd D,Casolari F,Depanfilis C,Maggini C,Baldessarini RJ

    更新日期:2007-11-01 00:00:00

  • The association between psychosis and severe pain in community-dwelling adults: Findings from 44 low- and middle-income countries.

    abstract::Previous studies examining the association between schizophrenia and pain have produced mixed results and data on sub-threshold psychosis or psychotic symptoms and pain are scarce. This study assessed the association between psychosis and severe pain among community-dwelling adults in 44 low- and middle-income countri...

    journal_title:Journal of psychiatric research

    pub_type: 杂志文章


    authors: Koyanagi A,Stickley A

    更新日期:2015-10-01 00:00:00

  • Psychotic depression in hospitalized patients: Longitudinal outcomes of psychotic vs. nonpsychotic depression among inpatients.

    abstract::Even though psychotic depression is related to worse outcomes than nonpsychotic depression, there is increasing evidence that this greater severity is not solely explained by the depressive symptoms. We evaluated the socio-demographic and clinical characteristics, as well as the differences in clinical outcomes of psy...

    journal_title:Journal of psychiatric research

    pub_type: 杂志文章


    authors: Costa FBPD,Trachtenberg E,Boni A,Primo de Carvalho Alves L,Magalhães PVDS,Rocha NS

    更新日期:2020-10-01 00:00:00

  • Persecutory ideation and anomalous perceptual experiences in the context of the COVID-19 outbreak in France: what's left one month later?

    abstract:PURPOSE:Beyond the effects of the coronavirus pandemic on the public's health, the length of lockdown and its possible psychological impacts on populations is heavily debated. However, the consequences of lockdown on psychotic symptoms have been poorly investigated. METHODS:An online survey was run from April 13 to Ma...

    journal_title:Journal of psychiatric research

    pub_type: 杂志文章


    authors: Bortolon C,Capdevielle D,Dubreucq J,Raffard S

    更新日期:2020-12-21 00:00:00

  • Prospective study of chronotype and incident depression among middle- and older-aged women in the Nurses' Health Study II.

    abstract:BACKGROUND:Prior cross-sectional studies have suggested that being a late chronotype is associated with depression and depressive symptoms, but prospective data are lacking. METHODS:We examined the association between chronotype and incident depression (defined as self-reported physician/clinician-diagnosed depression...

    journal_title:Journal of psychiatric research

    pub_type: 杂志文章


    authors: Vetter C,Chang SC,Devore EE,Rohrer F,Okereke OI,Schernhammer ES

    更新日期:2018-08-01 00:00:00

  • Arginine vasopressin and adrenocorticotropin secretion in response to psychosocial stress is attenuated by ethanol in sons of alcohol-dependent fathers.

    abstract::Familial risk and environmental stress promote the development of alcohol dependence. We investigated whether a positive family history of alcoholism affects the neuroendocrine response to a standardized laboratory stress test in healthy subjects without alcohol use disorders. Twenty-four high-risk subjects with a pat...

    journal_title:Journal of psychiatric research

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Zimmermann U,Spring K,Wittchen HU,Himmerich H,Landgraf R,Uhr M,Holsboer F

    更新日期:2004-07-01 00:00:00

  • Serum concentrations of brain-derived neurotrophic factor in patients with gender identity disorder.

    abstract::Gender Identity Disorder (GID) is characterized by a strong and persistent cross-gender identification that affects different aspects of behavior. Brain-derived neurotrophic factor (BDNF) plays a critical role in neurodevelopment and neuroplasticity. Altered BDNF-signaling is thought to contribute to the pathogenesis ...

    journal_title:Journal of psychiatric research

    pub_type: 杂志文章


    authors: Fontanari AM,Andreazza T,Costa ÂB,Salvador J,Koff WJ,Aguiar B,Ferrari P,Massuda R,Pedrini M,Silveira E,Belmonte-de-Abreu PS,Gama CS,Kauer-Sant'Anna M,Kapczinski F,Lobato MI

    更新日期:2013-10-01 00:00:00

  • Role of BDNF in bipolar and unipolar disorder: clinical and theoretical implications.

    abstract::A number of lines of converging evidence suggest that brain-derived neurotrophic factor (BDNF) may play a role in the onset and treatment of bipolar disorder. We review pertinent data on BDNF from several different areas of preclinical and clinical investigation that suggest novel theoretical and treatment implication...

    journal_title:Journal of psychiatric research

    pub_type: 杂志文章,评审


    authors: Post RM

    更新日期:2007-12-01 00:00:00

  • Anger precedes and predicts nonsuicidal self-injury in veterans: Findings from an ecological momentary assessment study.

    abstract::Veterans have high rates of suicide, and nonsuicidal self-injury (NSSI) is one of the strongest predictors of suicide risk; however, there is presently little known about antecedents of NSSI that might inform intervention efforts. Accumulating research suggests that anger and hostility play an important role in NSSI, ...

    journal_title:Journal of psychiatric research

    pub_type: 杂志文章


    authors: Dillon KH,Glenn JJ,Dennis PA,LoSavio ST,Cassiello-Robbins C,Gromatsky MA,Beckham JC,Calhoun PS,Kimbrel NA

    更新日期:2021-01-07 00:00:00

  • Evaluation of behavioral impulsivity and aggression tasks as endophenotypes for borderline personality disorder.

    abstract::Borderline personality disorder (BPD) is marked by aggression and impulsive, often self-destructive behavior. Despite the severe risks associated with BPD, relatively little is known about the disorder's etiology. Identification of genetic correlates (endophenotypes) of BPD would improve the prospects of targeted inte...

    journal_title:Journal of psychiatric research

    pub_type: 杂志文章


    authors: McCloskey MS,New AS,Siever LJ,Goodman M,Koenigsberg HW,Flory JD,Coccaro EF

    更新日期:2009-08-01 00:00:00

  • Course of comorbid anxiety disorders among adults with bipolar disorder in the U.S. population.

    abstract:OBJECTIVE:To examine the prevalence and correlates of comorbid anxiety disorders among individuals with bipolar disorders (BP) and their association with prospectively ascertained comorbidities, treatment, and psychosocial functioning. METHOD:As part of the National Epidemiologic Survey on Alcohol and Related Conditio...

    journal_title:Journal of psychiatric research

    pub_type: 杂志文章


    authors: Sala R,Goldstein BI,Morcillo C,Liu SM,Castellanos M,Blanco C

    更新日期:2012-07-01 00:00:00

  • TCF4 gene polymorphism is associated with cognition in patients with schizophrenia and healthy controls.

    abstract:BACKGROUND:Cognitive deficits have been identified as an important core feature of schizophrenia. Single nucleotide polymorphisms in the transcription factor 4 (TCF4) gene have been reported to be involved in the susceptibility to schizophrenia and be significantly related to cognitive deficits of schizophrenia and con...

    journal_title:Journal of psychiatric research

    pub_type: 杂志文章


    authors: Hui L,Rao WW,Yu Q,Kou C,Wu JQ,He JC,Ye MJ,Liu JH,Xu XJ,Zheng K,Ruan LN,Liu HY,Hu WM,Shao TN,AngRabanes MB,Soares JC,Zhang XY

    更新日期:2015-10-01 00:00:00

  • Deconstructing negative symptoms of schizophrenia: avolition-apathy and diminished expression clusters predict clinical presentation and functional outcome.

    abstract:BACKGROUND:Previous studies indicate that negative symptoms reflect a separable domain of pathology from other symptoms of schizophrenia. However, it is currently unclear whether negative symptoms themselves are multi-faceted, and whether sub-groups of patients who display unique negative symptom profiles can be identi...

    journal_title:Journal of psychiatric research

    pub_type: 杂志文章


    authors: Strauss GP,Horan WP,Kirkpatrick B,Fischer BA,Keller WR,Miski P,Buchanan RW,Green MF,Carpenter WT Jr

    更新日期:2013-06-01 00:00:00

  • The association between traumatic brain injury and ADHD in a Canadian adult sample.

    abstract:OBJECTIVE:This study describes the association between lifetime traumatic brain injury (TBI) and attention deficit and hyperactivity disorder (ADHD) among Canadian adults. METHOD:A cross-sectional sample of 3993 Ontario adults aged 18 or older were surveyed by Computer Assisted Telephone Interviewing (CATI) throughout...

    journal_title:Journal of psychiatric research

    pub_type: 杂志文章


    authors: Ilie G,Vingilis ER,Mann RE,Hamilton H,Toplak M,Adlaf EM,Kolla N,Ialomiteanu A,van der Mass M,Asbridge M,Vingilis-Jaremko L,Rehm J,Cusimano MD

    更新日期:2015-10-01 00:00:00

  • Extended-release venlafaxine in relapse prevention for patients with major depressive disorder.

    abstract::Many studies have demonstrated that venlafaxine is an efficacious and safe treatment for major depressive disorder (MDD). This double-blind, placebo-controlled study was performed to evaluate the efficacy of venlafaxine extended-release (XR) (75-225 mg/day) in the prevention of relapse of depression. Patients with MDD...

    journal_title:Journal of psychiatric research

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Simon JS,Aguiar LM,Kunz NR,Lei D

    更新日期:2004-05-01 00:00:00

  • The subjective-objective deficit paradox in schizotypy extends to emotion regulation and awareness.

    abstract::There is an emerging subjective-objective deficit paradox in schizotypy. Individuals with schizotypy report severe subjective complaints in several key functional domains commensurate with that of individuals with schizophrenia. However, objective assessments of the same domains show relatively intact performance. We ...

    journal_title:Journal of psychiatric research

    pub_type: 杂志文章


    authors: Li LY,Karcher NR,Kerns JG,Fung CK,Martin EA

    更新日期:2019-04-01 00:00:00

  • Maternal choline and respiratory coronavirus effects on fetal brain development.

    abstract::Prenatal COVID-19 infection is anticipated by the U.S. Centers for Disease Control to affect fetal development similarly to other common respiratory coronaviruses through effects of the maternal inflammatory response on the fetus and placenta. Plasma choline levels were measured at 16 weeks gestation in 43 mothers who...

    journal_title:Journal of psychiatric research

    pub_type: 杂志文章


    authors: Freedman R,Hunter SK,Law AJ,D'Alessandro A,Noonan K,Wyrwa A,Camille Hoffman M

    更新日期:2020-09-01 00:00:00

  • DSM-III-R schizotypal personality traits in offspring of schizophrenic disorder, affective disorder, and normal control parents.

    abstract::The aggregation of disorder in families identified by a schizophrenic disorder proband (index case) has provided indirect clues to the question of diagnostic boundaries of schizophrenic spectrum categories. The Danish Adoption Studies provided quasi-experimental evidence for the range of expression of a putative schiz...

    journal_title:Journal of psychiatric research

    pub_type: 杂志文章


    authors: Squires-Wheeler E,Skodol AE,Bassett A,Erlenmeyer-Kimling L

    更新日期:1989-01-01 00:00:00

  • Treatments for blood-injury-injection phobia: a critical review of current evidence.

    abstract::Blood-injury-injection (BII) phobia presents with a unique anxiety response that often involves blood pressure drops and pronounced bradycardia, which can culminate in fainting. The current recommended treatment for BII phobia is Applied Tension (AT), a tension technique that includes in vivo exposure. However, surpri...

    journal_title:Journal of psychiatric research

    pub_type: 杂志文章,评审


    authors: Ayala ES,Meuret AE,Ritz T

    更新日期:2009-10-01 00:00:00

  • Dietary intake and plasma metabolomic analysis of polyunsaturated fatty acids in bipolar subjects reveal dysregulation of linoleic acid metabolism.

    abstract::Polyunsaturated fatty acids (PUFA) profiles associate with risk for mood disorders. This poses the hypothesis of metabolic differences between patients and unaffected healthy controls that relate to the primary illness or are secondary to medication use or dietary intake. However, dietary manipulation or supplementati...

    journal_title:Journal of psychiatric research

    pub_type: 杂志文章


    authors: Evans SJ,Ringrose RN,Harrington GJ,Mancuso P,Burant CF,McInnis MG

    更新日期:2014-10-01 00:00:00

  • The effect of therapeutically induced weight gain on plasma leptin levels in patients with anorexia nervosa.

    abstract::Previously it was shown that hyperleptinemia ensues from the therapeutically induced weight gain in patients with anorexia nervosa (AN). However, not all studies have been able to confirm this finding. To further investigate leptin secretion during weight gain in AN and potential functional implications serum leptin l...

    journal_title:Journal of psychiatric research

    pub_type: 临床试验,杂志文章


    authors: Holtkamp K,Hebebrand J,Mika C,Grzella I,Heer M,Heussen N,Herpertz-Dahlmann B

    更新日期:2003-03-01 00:00:00

  • Adjuvant use of nutritional and herbal medicines with antidepressants, mood stabilizers and benzodiazepines.

    abstract::Adjuvant use of nutritional and herbal medicines has potential to increase the efficacy of synthetic pharmaceuticals, and perhaps also decrease their side-effects by allowing lower doses to be prescribed. We evaluated current evidence for adjuvant use of nutritional and herbal medicines with antidepressants, mood stab...

    journal_title:Journal of psychiatric research

    pub_type: 杂志文章,评审


    authors: Sarris J,Kavanagh DJ,Byrne G

    更新日期:2010-01-01 00:00:00

  • The Munich vulnerability study on affective disorders: premorbid neuroendocrine profile of affected high-risk probands.

    abstract::One of the most characteristic alterations in depression is a disturbed regulation of the hypothalamic-pituitary-adrenocortical (HPA) system. A function test combining the pre-treatment of 1.5 mg dexamethasone (DEX) with a challenge of 100 microg corticotropin-releasing hormone (CRH) reveals a pathological increase in...

    journal_title:Journal of psychiatric research

    pub_type: 杂志文章


    authors: Ising M,Lauer CJ,Holsboer F,Modell S

    更新日期:2005-01-01 00:00:00

  • Folate, homocysteine, interleukin-6, and tumor necrosis factor alfa levels, but not the methylenetetrahydrofolate reductase C677T polymorphism, are risk factors for schizophrenia.

    abstract::The methylenetetrahydrofolate reductase (MTHFR) C677T mutation has been associated to high homocysteine levels and schizophrenia. Since cytokines are altered in schizophrenia and increments of homocysteine could promote an inflammatory response, it was investigated whether interleukin-6 (IL-6) and tumor necrosis facto...

    journal_title:Journal of psychiatric research

    pub_type: 杂志文章


    authors: García-Miss Mdel R,Pérez-Mutul J,López-Canul B,Solís-Rodríguez F,Puga-Machado L,Oxté-Cabrera A,Gurubel-Maldonado J,Arankowsky-Sandoval G

    更新日期:2010-05-01 00:00:00

  • Longitudinal assessment of inpatient use and functioning of seriously mentally ill veterans with and without co-occurring substance use disorders.

    abstract::The purpose of this study was to delineate differences in inpatient service utilization and functional and subjective outcomes between veterans with a serious mental illness (SMI) and those with co-occurring serious mental illnesses and substance abuse (SA) disorders. This study assessed 2-year inpatient utilization a...

    journal_title:Journal of psychiatric research

    pub_type: 杂志文章


    authors: Blow FC,Barry KL,BootsMiller BJ,Copeland LA,McCormick R,Visnic S

    更新日期:1998-09-01 00:00:00

  • Hypericum perforatum differentially affects corticosteroid receptor-mRNA expression in human monocytic U-937 cells.

    abstract::A dysregulation of the hypothalamic-pituitary-adrenocortical (HPA) axis represents a prominent finding in major depression, possibly related to a dysfunction of the corticosteroid receptor system. Antidepressants are involved in the restoration of the altered feed-back mechanism of the HPA-axis, probably via normaliza...

    journal_title:Journal of psychiatric research

    pub_type: 杂志文章


    authors: Enning F,Murck H,Krieg JC,Vedder H

    更新日期:2011-09-01 00:00:00

  • The combination of triiodothyronine (T3) and sertraline is not superior to sertraline monotherapy in the treatment of major depressive disorder.

    abstract:OBJECTIVE:To determine whether the combination of triiodothyronine (T3) plus sertraline at treatment initiation confers greater antidepressant efficacy than sertraline plus placebo in patients with major depressive disorder. METHOD:Eight-week, double blind, randomized placebo controlled clinical trial of 153 adult out...

    journal_title:Journal of psychiatric research

    pub_type: 杂志文章,随机对照试验


    authors: Garlow SJ,Dunlop BW,Ninan PT,Nemeroff CB

    更新日期:2012-11-01 00:00:00

  • Ligands and receptors of the TNF superfamily are decreased in major depression and during early antidepressant therapy.

    abstract:BACKGROUND:The up-regulation of pro-inflammatory agents, amongst them tumor necrosis factor (TNF), may represent low-grade inflammation in major depression. To further elucidate inflammatory mechanisms related to TNF in depression, the aim of the current study was to investigate the involvement of ligands and receptors...

    journal_title:Journal of psychiatric research

    pub_type: 杂志文章


    authors: Schmidt FM,Koch J,Nowak C,Holdt LM,Teupser D,Hegerl U,Himmerich H

    更新日期:2019-12-01 00:00:00

  • Relationships between psychological distress, coping styles, and HPA axis reactivity in healthy adults.

    abstract::Psychological distress and coping styles have been suggested to relate to altered function in the hypothalamic-pituitary-adrenal (HPA) axis, although there remains much to be understood about their relationships. High and low cortisol levels (or reactivity) both represent HPA axis dysfunction, with accumulated evidenc...

    journal_title:Journal of psychiatric research

    pub_type: 杂志文章


    authors: Hori H,Ozeki Y,Teraishi T,Matsuo J,Kawamoto Y,Kinoshita Y,Suto S,Terada S,Higuchi T,Kunugi H

    更新日期:2010-10-01 00:00:00

  • Increased levels of serum leptin in the early stages of psychosis.

    abstract:BACKGROUND:Studies evaluating leptin levels in patients with first-episode psychoses (FEP) have been inconclusive, and apparently, the high levels of leptin reported in patients with schizophrenia may be associated with weight gain. The aim of this study was to evaluate leptin levels at the early stages of the disease ...

    journal_title:Journal of psychiatric research

    pub_type: 杂志文章


    authors: Martorell L,Muntané G,Porta-López S,Moreno I,Ortega L,Montalvo I,Sanchez-Gistau V,Monseny R,Labad J,Vilella E

    更新日期:2019-04-01 00:00:00