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Mice with ablated adult brain neurogenesis are not impaired in antidepressant response to chronic fluoxetine.

Abstract：

:The neurogenesis hypothesis of major depression has two main facets. One states that the illness results from decreased neurogenesis while the other claims that the very functioning of antidepressants depends on increased neurogenesis. In order to verify the latter, we have used cyclin D2 knockout mice (cD2 KO mice), known to have virtually no adult brain neurogenesis, and we demonstrate that these mice successfully respond to chronic fluoxetine. After unpredictable chronic mild stress, mutant mice showed depression-like behavior in forced swim test, which was eliminated with chronic fluoxetine treatment, despite its lack of impact on adult hippocampal neurogenesis in cD2 KO mice. Our results suggest that new neurons are not indispensable for the action of antidepressants such as fluoxetine. Using forced swim test and tail suspension test, we also did not observe depression-like behavior in control cD2 KO mice, which argues against the link between decreased adult brain neurogenesis and major depression.

journal_name

J Psychiatr Res

journal_title

Journal of psychiatric research

authors

Jedynak P,Kos T,Sandi C,Kaczmarek L,Filipkowski RK

doi

10.1016/j.jpsychires.2014.05.009

subject

Has Abstract

pub_date

2014-09-01 00:00:00

pages

106-11

eissn

0022-3956

issn

1879-1379

pii

S0022-3956(14)00147-2

journal_volume

56

pub_type

杂志文章

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