当前位置： SCI文献检索 > JOURNAL OF PSYCHIATRIC RESEARCH期刊下所有文献 > Disrupted functional connectivity of the locus coeruleus in healthy adults with parental history of Alzheimer's disease.

Disrupted functional connectivity of the locus coeruleus in healthy adults with parental history of Alzheimer's disease.

Abstract：

:Prevention and early treatment strategies for Alzheimer's disease (AD) are hampered by the lack of research biomarkers. Neuropathological changes in the Locus Coeruleus (LC) are detected early in AD, and noradrenaline plays a neuroprotective role in LC projecting areas. We assessed functional connectivity (FC) of the brainstem in asymptomatic individuals at familial risk for AD hypothesizing that FC of the LC will be decreased in relation to not-at-risk individuals. Thirty-one offspring of patients with late-onset AD (O-LOAD) (22 females; mean age ± SD = 50.36 ± 8.32) and 28 healthy controls (HC) (20 females; mean age ± SD = 53.90 ± 8.44) underwent a neurocognitive evaluation and a resting-state functional magnetic resonance imaging acquisition. In FC analyses we evaluated whole-brain global connectivity of the brainstem area, and subsequently assessed seed-to-voxel FC patterns from regions showing between-group differences. O-LOAD individuals scored worse in neurocognitive measures of memory and overall functioning (pFDR<0.05). In imaging analyses, we observed that O-LOAD individuals showed decreased global connectivity in a cluster encompassing the left LC (peak = -4, -34, -32, pTFCE<0.05). Seed-to-voxel analyses revealed that this finding was largely explained by decreased connectivity between the LC and the cerebellar cortex. Moreover, FC between the LC and the left cerebellum correlated positively with delayed recall scores. FC between the LC and the cerebellar cortex is decreased in the healthy offspring of patients with LOAD, such connectivity measurements being associated with delayed memory scores. The assessment of FC between the LC and the cerebellum may serve as a biomarker of AD vulnerability.

journal_name

J Psychiatr Res

journal_title

Journal of psychiatric research

authors

Del Cerro I,Villarreal MF,Abulafia C,Duarte-Abritta B,Sánchez SM,Castro MN,Bocaccio H,Ferrer I,Menchón JM,Sevlever G,Nemeroff CB,Soriano-Mas C,Guinjoan SM

doi

10.1016/j.jpsychires.2020.01.018

subject

Has Abstract

pub_date

2020-04-01 00:00:00

pages

81-88

eissn

0022-3956

issn

1879-1379

pii

S0022-3956(19)31177-X

journal_volume

123

pub_type

杂志文章

相关文献

JOURNAL OF PSYCHIATRIC RESEARCH文献大全
  • Plasma S-100B protein in Chinese patients with schizophrenia: comparison with healthy controls and effect of antipsychotics treatment.

    abstract：PURPOSE:To examine the possibility that structural damage to the brain may play a role in the pathogenesis of schizophrenia by measuring the level of plasma S-100B, a calcium-binding protein found predominantly in the cytosol of glial cells. METHOD:Fifty-seven Chinese psychiatric inpatients who met DSM-IV diagnosis of...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2005.11.006

    authors： Ling SH,Tang YL,Jiang F,Wiste A,Guo SS,Weng YZ,Yang TS

    更新日期：2007-01-01 00:00:00

  • Temporal sequencing of nicotine dependence and bipolar disorder in the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC).

    abstract：:Bipolar disorder (BD) and nicotine dependence (ND) often co-occur. However, the mechanisms underlying this association remain unclear. We aimed to examine, for the first time in a national and representative sample, the magnitude and direction of the temporal relationship between BD and ND; and to compare, among indiv...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2013.03.012

    authors： Martínez-Ortega JM,Goldstein BI,Gutiérrez-Rojas L,Sala R,Wang S,Blanco C

    更新日期：2013-07-01 00:00:00

  • Suicide risk in Iraq and Afghanistan veterans with mental health problems in VA care.

    abstract：:Suicide rates among U.S. military personnel and veterans are a public health concern, and those with mental health conditions are at particular risk. We examined demographic, military, temporal, and diagnostic associations with suicidality in veterans. We conducted a population-based, retrospective cohort study of all...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2015.06.013

    authors： Maguen S,Madden E,Cohen BE,Bertenthal D,Neylan TC,Seal KH

    更新日期：2015-09-01 00:00:00

  • Escitalopram but not placebo modulates brain rhythmic oscillatory activity in the first week of treatment of Major Depressive Disorder.

    abstract：:Serotonin modulates brain oscillatory activity, and serotonergic projections to the thalamus and cortex modulate the frequency of prefrontal rhythmic oscillations. Changes in serotonergic tone have been reported to shift oscillations between the combined delta-theta (2.5-8 Hz) and the alpha (8-12 Hz) frequency ranges....

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.jpsychires.2016.10.002

    authors： Leuchter AF,Hunter AM,Jain FA,Tartter M,Crump C,Cook IA

    更新日期：2017-01-01 00:00:00

  • The emerging field of retinal electrophysiological measurements in psychiatric research: A review of the findings and the perspectives in major depressive disorder.

    abstract：:Major depressive disorder (MDD) is a severe mental illness leading to long-term disabilities. One of the current challenges in psychiatric research is to develop new approaches to investigate the pathophysiology of MDD and monitor drug response in order to provide better therapeutic strategies to the patients. Since t...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章,评审

    doi：10.1016/j.jpsychires.2015.09.003

    authors： Schwitzer T,Lavoie J,Giersch A,Schwan R,Laprevote V

    更新日期：2015-11-01 00:00:00

  • Familial aggregation in Alzheimer dementia--II. Clinical genetic implications of age-dependent onset.

    abstract：:A biomathematical genetic model for the age-specific risk of Alzheimer Dementia (AD) was applied to two problems in the clinical genetics of this disorder. In a test of the ability of a clinical marker specifically to identify genetic AD, cases grouped by the phenotype of amnesia with aphasia or apraxia (aaa) were sho...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/0022-3956(86)90022-1

    authors： Breitner JC,Murphy EA,Folstein MF

    更新日期：1986-01-01 00:00:00

  • The epidemiology of major depression and ethnicity in the United States.

    abstract：OBJECTIVES:To determine the prevalence, age of onset, severity, associated disability, and treatment of major depression among United States ethnic groups, national survey data were analyzed. METHODS:National probability samples of US household residents aged 18-years and older (n=14,710) participated. The main outcom...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2010.03.017

    authors： González HM,Tarraf W,Whitfield KE,Vega WA

    更新日期：2010-11-01 00:00:00

  • The impact of psychiatric illness on suicide: differences by diagnosis of disorders and by sex and age of subjects.

    abstract：:People with a psychiatric illness are at high risk for suicide; however, variation of the risk by patients' sex and age and by specific diagnosis needs to be explored in a more detail. This large population study systematically assesses suicide incidence rate ratio (IRR) and population attributable risk (PAR) associat...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2011.06.002

    authors： Qin P

    更新日期：2011-11-01 00:00:00

  • A learning algorithm for predicting mental health symptoms and substance use.

    abstract：:Learning health systems use data to generate knowledge that informs clinical care, but few studies have evaluated how to leverage patient-reported mental health symptoms and substance use data to make patient-specific predictions. We developed a general Bayesian prediction algorithm that uses self-reported psychiatric...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2020.12.049

    authors： Fojo AT,Lesko CR,Benke KS,Chander G,Lau B,Moore RD,Zandi PP,Zeger SL

    更新日期：2020-12-19 00:00:00

  • Posttraumatic stress disorder and nonadherence to medications prescribed for chronic medical conditions: A meta-analysis.

    abstract：BACKGROUND:Patients with posttraumatic stress disorder (PTSD) are at increased risk for adverse consequences from comorbid medical conditions. Nonadherence to medications prescribed to treat those comorbid conditions may help explain this increased risk. We sought to determine the association between PTSD and medicatio...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.jpsychires.2018.02.013

    authors： Taggart Wasson L,Shaffer JA,Edmondson D,Bring R,Brondolo E,Falzon L,Konrad B,Kronish IM

    更新日期：2018-07-01 00:00:00

  • Sluggish cognitive tempo and ADHD symptoms in relation to task-unrelated thought: Examining unique links with mind-wandering and rumination.

    abstract：:Recent theoretical and empirical evidence highlights associations between attention-deficit/hyperactivity disorder (ADHD) symptoms and task-unrelated thought, including mind-wandering and rumination. However, it has been hypothesized that sluggish cognitive tempo (SCT), characterized by daydreaming and staring behavio...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2020.01.016

    authors： Fredrick JW,Kofler MJ,Jarrett MA,Burns GL,Luebbe AM,Garner AA,Harmon SL,Becker SP

    更新日期：2020-04-01 00:00:00

  • Relationship of optimism and suicidal ideation in three groups of patients at varying levels of suicide risk.

    abstract：:Optimism has been associated with reduced suicidal ideation, but there have been few studies in patients at high suicide risk. We analyzed data from three study populations (total N = 319) with elevated risk of suicide: (1) patients with a recent acute cardiovascular event, (2) patients hospitalized for heart disease ...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.jpsychires.2016.02.020

    authors： Huffman JC,Boehm JK,Beach SR,Beale EE,DuBois CM,Healy BC

    更新日期：2016-06-01 00:00:00

  • Subjective age and risk of incident dementia: Evidence from the National Health and Aging Trends survey.

    abstract：:The present study examines the association between subjective age and risk of incident dementia in a large longitudinal sample of older adults. Participants were adults aged 65 years and older from the National Health and Aging Trends Study (NHATS). Subjective age, covariates, and cognitive status were assessed in 201...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2018.02.008

    authors： Stephan Y,Sutin AR,Luchetti M,Terracciano A

    更新日期：2018-05-01 00:00:00

  • Non response at week 4 as clinically useful indicator for antidepressant combination in major depressive disorder. A sequential RCT.

    abstract：:We aimed to compare the efficacy and tolerability of mirtazapine versus SSRIs and to assess whether "non-response at week 4" may be a clinical indicator for combining mirtazapine and SSRIs for subsequent treatment. One-hundred fifty-four outpatients with MDD were randomized to receive mirtazapine or SSRIs in step I (4...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.jpsychires.2017.02.003

    authors： Kato M,Takekita Y,Koshikawa Y,Sakai S,Bandou H,Nishida K,Sunada N,Onohara A,Hatashita Y,Serretti A,Kinoshita T

    更新日期：2017-06-01 00:00:00

  • Immune response to stress induction as a predictor of cognitive-behavioral therapy outcomes in adolescent mood disorders: A pilot study.

    abstract：:Cognitive-behavioral therapy (CBT) alleviates symptoms of depression in youth with bipolar disorder (BD) and major depressive disorder (MDD). Empirical research has linked inflammatory markers to depressive symptoms and acute psychosocial stress; however, a gap remains as to whether immune response to stress may serve...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2019.10.012

    authors： Pearlstein JG,Staudenmaier PJ,West AE,Geraghty S,Cosgrove VE

    更新日期：2020-01-01 00:00:00

  • Impaired binocular depth inversion in patients with alcohol withdrawal.

    abstract：:Binocular depth inversion represents an illusion of visual perception. Such inversion does not occur in all cases, especially when objects with a higher degree of familiarity (e.g. photographs of faces) are displayed. Cognitive factors are assumed to override the binocular disparity cues of stereopsis. We tested the h...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/s0022-3956(96)00031-3

    authors： Schneider U,Leweke FM,Niemcyzk W,Sternemann U,Bevilacqua M,Emrich HM

    更新日期：1996-11-01 00:00:00

  • CNTNAP2 polymorphisms and structural brain connectivity: a diffusion-tensor imaging study.

    abstract：:CNTNAP2 is a gene on chromosome 7 that has shown associations with autism and schizophrenia, and there is evidence that it plays an important role for neuronal synchronization and brain connectivity. In this study, we assessed the relationship between Diffusion Tensor Imaging (DTI), a putative marker of anatomical bra...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2013.07.002

    authors： Clemm von Hohenberg C,Wigand MC,Kubicki M,Leicht G,Giegling I,Karch S,Hartmann AM,Konte B,Friedl M,Ballinger T,Eckbo R,Bouix S,Jäger L,Shenton ME,Rujescu D,Mulert C

    更新日期：2013-10-01 00:00:00

  • READMIT: a clinical risk index to predict 30-day readmission after discharge from acute psychiatric units.

    abstract：:Our aim was to create a clinically useful risk index, administered prior to discharge, for determining the probability of psychiatric readmission within 30 days of hospital discharge for general psychiatric inpatients. We used population-level sociodemographic and health administrative data to develop a predictive mod...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2014.12.003

    authors： Vigod SN,Kurdyak PA,Seitz D,Herrmann N,Fung K,Lin E,Perlman C,Taylor VH,Rochon PA,Gruneir A

    更新日期：2015-02-01 00:00:00

  • Enlarged cerebellar vermis in Williams syndrome.

    abstract：:Williams syndrome (WMS) is a rare genetic disorder characterized by relative preservations of language ability and facial processing despite deficits in overall intelligence, problem solving, and visuospatial processing. Subjects with WMS also display hypersocial behavior and excessive linguistic affect during convers...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/s0022-3956(01)00024-3

    authors： Schmitt JE,Eliez S,Warsofsky IS,Bellugi U,Reiss AL

    更新日期：2001-07-01 00:00:00

  • Persistent mental health impacts of disaster. Five-year follow-up after the 2011 great east Japan earthquake and tsunami: Iwanuma Study.

    abstract：:Few studies have tracked the long-term mental health outcomes following major disaster. We sought to document the trajectories of depressive symptoms and post-traumatic stress symptoms (PTSS) in the aftermath of the 2011 Great East Japan earthquake and tsunami. A cohort of community-dwelling older adults were followed...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2020.08.016

    authors： Kino S,Aida J,Kondo K,Kawachi I

    更新日期：2020-08-23 00:00:00

  • Continuous infusion versus intermittent bolus dosing of morphine: a comparison of analgesia, tolerance, and subsequent voluntary morphine intake.

    abstract：:Improved utilization of continuous or intermittent opioid administration in pain treatment necessitates a comparison of the antinociceptive effect and tolerance of these two treatment methods. More importantly, the effect of treatment method on subsequent opioid consumption has not been directly compared, although it ...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2014.08.009

    authors： Yu G,Zhang FQ,Tang SE,Lai MJ,Su RB,Gong ZH

    更新日期：2014-12-01 00:00:00

  • Association of PTSD with COVID-19 testing and infection in the Veterans Health Administration.

    abstract：:Posttraumatic stress disorder (PTSD) is associated with coronavirus disease 2019 (COVID-19) risk factors, such as hypertension and obesity. Associations between PTSD and COVID-19 outcomes may affect Veterans Health Administration (VA) services, as PTSD occurs at higher rates among veterans than the general population....

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2020.11.033

    authors： Haderlein TP,Wong MS,Yuan A,Llorente MD,Washington DL

    更新日期：2020-11-23 00:00:00

  • Impact of peripheral levels of chemokines, BDNF and oxidative markers on cognition in individuals with schizophrenia.

    abstract：OBJECTIVE:To investigate possible differences in peripheral levels of chemokines, BDNF and oxidative markers between patients with Schizophrenia (SZ) and matched healthy controls, and investigate the correlation of these biomarkers with cognitive performance. METHODS:Thirty individuals with SZ and 27 healthy controls ...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2013.05.032

    authors： Asevedo E,Gadelha A,Noto C,Mansur RB,Zugman A,Belangero SI,Berberian AA,Scarpato BS,Leclerc E,Teixeira AL,Gama CS,Bressan RA,Brietzke E

    更新日期：2013-10-01 00:00:00

  • Alterations of oscillatory neuronal activity during reward processing in schizophrenia.

    abstract：OBJECTIVES:Reward system dysfunctions are considered to be a pathophysiological mechanism in schizophrenia. Electrophysiological studies of reward system functions have identified frequency-specific brain networks for the processing of positive (high-beta frequency) and negative (theta frequency) events. Remarkably, mi...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2020.05.031

    authors： Leicht G,Andreou C,Nafe T,Nägele F,Rauh J,Curic S,Schauer P,Schöttle D,Steinmann S,Mulert C

    更新日期：2020-10-01 00:00:00

  • Migraine and depression: association and familial transmission.

    abstract：:We have studied the association between migraine and major depression in a group of 133 probands with major depression, a group of 82 normal community controls and 400 interviewed first-degree relatives of the probands and controls. There was a significant association between depression and migraine among both the pro...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/0022-3956(88)90076-3

    authors： Merikangas KR,Risch NJ,Merikangas JR,Weissman MM,Kidd KK

    更新日期：1988-01-01 00:00:00

  • Age at onset in bipolar-related major affective illness: clinical and genetic implications.

    abstract：:Age-of-onset data were collected on 142 bipolar probands (61 males, 81 females) and 110 siblings. After correcting for demographic factors the age at illness onset did not distinguish bipolar from unipolar siblings or siblings from probands. This indicates that in a subset of pedigree data, bipolar and unipolar affect...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/0022-3956(82)90030-9

    authors： Baron M,Risch N,Mendlewicz J

    更新日期：1982-01-01 00:00:00

  • Effects of aerobic walking on cognitive function in patients with schizophrenia: A randomized controlled trial.

    abstract：:Cognitive deficits, which are core manifestations in schizophrenia and exhibit a limited response to antipsychotic treatment, contribute to poor treatment outcomes and functional disability. Evidence on the effect of aerobic walking (AW) and exercise intensity on cognitive function in patients with schizophrenia is la...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2020.12.062

    authors： Huang YC,Hung CF,Hsu ST,Lin PY,Lee Y,Chong MY,Chen CC,Kuo YH,Wang LJ

    更新日期：2020-12-24 00:00:00

  • Elevated Hippocampal Cholinergic Neurostimulating Peptide precursor protein (HCNP-pp) mRNA in the amygdala in major depression.

    abstract：:The amygdala is innervated by the cholinergic system and is involved in major depressive disorder (MDD). Evidence suggests a hyper-activate cholinergic system in MDD. Hippocampal Cholinergic Neurostimulating Peptide (HCNP) regulates acetylcholine synthesis. The aim of the present work was to investigate expression lev...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2015.02.006

    authors： Bassi S,Seney ML,Argibay P,Sibille E

    更新日期：2015-04-01 00:00:00

  • A twin study of amino acid concentrations in cerebrospinal fluid.

    abstract：:The concentrations of amino acids in the cerebrospinal fluid (CSF) were measured in pairs of healthy mono- and dizygotic twins. Intraclass correlations were calculated. Genetic and cultural heritabilities were estimated using a path analytical model. CSF levels of glycine, tyrosine and arginine were shown to be influe...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/0022-3956(88)90028-3

    authors： Hagenfeldt L,Oxenstierna G,Alfredsson G,Edman G,Iselius L,Sedvall G

    更新日期：1988-01-01 00:00:00

  • Maternal immune activation leads to behavioral and pharmacological changes in the adult offspring.

    abstract：:Maternal exposure to viral infection has been associated with an increased risk of schizophrenia in the offspring, and it has been suggested that the maternal immune response may interfere with normal fetal brain development. Although studies in rodents have shown that perinatal viral infections can lead to neuropatho...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2004.08.008

    authors： Zuckerman L,Weiner I

    更新日期：2005-05-01 00:00:00