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Discrimination between schizophrenia and major depressive disorder by magnetic resonance imaging of the female brain.

Abstract：

BACKGROUND:Although schizophrenia and major depressive disorder (MDD) differ on a variety of neuroanatomical measures, a diagnostic tool to discriminate these disorders has not yet been established. We tried to identify structural changes of the brain that best discriminate between schizophrenia and MDD on the basis of gray matter volume, ventricle volume, and diffusion tensor imaging (DTI). METHOD:The first exploration sample consisted of 25 female patients with schizophrenia and 25 females with MDD. Regional brain volumes and fractional anisotropy (FA) values were entered into a discriminant analysis. The second validation sample consisted of 18 female schizophrenia and 16 female MDD patients. RESULTS:The stepwise discriminant analysis resulted in correct classification rates of 0.80 in the schizophrenic group and 0.76 in MDD. In the second validation sample, the obtained model yielded correct classification rates of 0.72 in the schizophrenia group and 0.88 in the MDD group. CONCLUSION:Our results suggest that schizophrenia and MDD have differential structural changes in the examined brain regions and that the obtained discriminant score may be useful to discriminate the two disorders.

journal_name

J Psychiatr Res

journal_title

Journal of psychiatric research

authors

Ota M,Ishikawa M,Sato N,Hori H,Sasayama D,Hattori K,Teraishi T,Noda T,Obu S,Nakata Y,Higuchi T,Kunugi H

doi

10.1016/j.jpsychires.2013.06.010

subject

Has Abstract

pub_date

2013-10-01 00:00:00

pages

1383-8

issue

10

eissn

0022-3956

issn

1879-1379

pii

S0022-3956(13)00193-3

journal_volume

47

pub_type

杂志文章

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