Abstract：
:Evidence is accumulating that aldosterone may exert central actions and influence mental functions. The aim of the present study was to test the hypothesis that major depressive disorder affects the diurnal variation of salivary aldosterone and that aldosterone concentrations reflect the duration and severity of the depressive episode in a sex dependent manner. The sample consisted of 60 patients (37 postmenopausal women, 23 men) with major depressive disorder. Patients were examined two times, in acute depressive episode (admission to the hospital) and after reaching clinical remission (discharge). The samples of saliva were taken by the patients themselves twice a day (8.00-9.00 h in the morning and in the evening). Aldosterone concentrations were significantly higher in women compared to men and were significantly higher at the time of admission to the hospital compared to those at the discharge. Morning but not evening salivary aldosterone concentrations reflected the length of the depressive episode in women as well as the severity of the disorder in both sexes. Moreover, the patients with depression failed to exert known daily rhythmicity of aldosterone release. The present study brings several pieces of evidence suggesting the association of aldosterone with the pathophysiology of depression. Salivary aldosterone concentrations appear to reflect the outcome, the duration and the severity of the depressive episode in a sex dependent manner.
journal_name
J Psychiatr Resjournal_title
Journal of psychiatric researchauthors
Segeda V,Izakova L,Hlavacova N,Bednarova A,Jezova Ddoi
10.1016/j.jpsychires.2017.04.011subject
Has Abstractpub_date
2017-08-01 00:00:00pages
164-168eissn
0022-3956issn
1879-1379pii
S0022-3956(17)30193-0journal_volume
91pub_type
杂志文章abstract：:The first genome-wide association study of human memory identified an association between a common T/C polymorphism of the KIBRA gene (rs17070145) and episodic memory performance in normal individuals; subsequent studies have implicated the same polymorphism in Alzheimer's disease. Since impaired neurocognitive perfor...
journal_title：Journal of psychiatric research
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journal_title：Journal of psychiatric research
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journal_title：Journal of psychiatric research
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journal_title：Journal of psychiatric research
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更新日期：1998-11-01 00:00:00
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pub_type： 杂志文章,评审
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journal_title：Journal of psychiatric research
pub_type： 杂志文章
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journal_title：Journal of psychiatric research
pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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journal_title：Journal of psychiatric research
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