Abstract：
BACKGROUND:Previous research has demonstrated altered neuronal responses to visual stimulation with food in anorexia nervosa, varying with the motivational state of hunger or satiety. The aim of the present fMRI study was to assess hunger- and satiety-dependent alterations in the gustatory processing of stimulation with food in anorexia nervosa. METHODS:After food abstention (hunger condition) and after eating bread rolls with cheese (satiety condition), 12 females with restricting-type anorexia nervosa and 12 healthy females drank chocolate milk and water via a tube in a blocked design during image acquisition. Additionally, heart rate was registered during the measurements, and subjective ratings of hunger/satiety and of the valence of chocolate milk were assessed using a Likert scale. RESULTS:In participants with anorexia nervosa, drinking chocolate milk in the hunger condition induced significant activations in the right amygdala and in the left medial temporal gyrus relative to healthy controls. When contrasting neuronal responses to drinking chocolate milk during satiety with those evoked during hunger, a significant activation was found in the left insula in healthy controls, whereas in participants with anorexia nervosa, neuronal activity in the inferior temporal gyrus, covering the extrastriate body area, was observed. CONCLUSIONS:Neuronal responses evoked by gustatory stimulation differ depending on hunger and satiety. Activations located in the amygdala and in the extrastriate body area might reflect fear of weight gain, representing one of the core symptoms of anorexia nervosa.
journal_name
J Psychiatr Resjournal_title
Journal of psychiatric researchauthors
Vocks S,Herpertz S,Rosenberger C,Senf W,Gizewski ERdoi
10.1016/j.jpsychires.2010.07.012subject
Has Abstractpub_date
2011-03-01 00:00:00pages
395-403issue
3eissn
0022-3956issn
1879-1379pii
S0022-3956(10)00231-1journal_volume
45pub_type
杂志文章abstract：:Prevalence figures of depression usually show a sex ratio for males:females of 1:2. This unequal ratio has been examined by varying the time periods for the calculation of prevalance rates and the criteria for case definition. Based on results of a 20-23 yr-old cohort of 591 males and females studied in Switzerland, s...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/0022-3956(84)90029-3
更新日期：1984-01-01 00:00:00
abstract：:Structural neuroimaging studies investigating amygdala volumes in patients suffering from major depression have yielded variable results. Discrepant findings across studies may be attributable in part to heterogeneity with respect to antidepressant medication and to lack of adequate control for the effects of total br...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2009.03.007
更新日期：2009-09-01 00:00:00
abstract：:Appetite and satiety responses in a test meal paradigm were studied in six anorexia nervosa patients (four had bingeing and purging behaviors) and in nine normal control women. The anorexic patients were distinguished from normal controls by the amounts of food taken and by the pattern of the hunger and fullness respo...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/0022-3956(85)90029-9
更新日期：1985-01-01 00:00:00
abstract：:Genetic factors contribute to the risk of psychopathology in many psychiatric conditions, but the specific genes are yet to be identified. Neurotransmitter alterations are implicated in the etiology of psychopathology based, in part, on studies of neurotransmitter receptors and their biosynthetic or degradative enzyme...
journal_title：Journal of psychiatric research
pub_type： 杂志文章,评审
doi：10.1016/s0022-3956(03)00048-7
更新日期：2003-09-01 00:00:00
abstract：:Eating disorders (ED) are severe psychiatric diseases that most likely result from, and are sustained by socio-cultural, psychological and biological factors. We explored whether members of the neurotrophin family are disease-modifying factors of quantitative traits, potentially contributing to the outcome or prognosi...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2010.01.009
更新日期：2010-10-01 00:00:00
abstract：:Diagnosing major depressive disorder (MDD) continues to be based on meeting phenomenological and descriptive criteria. As of yet, there is still no non-invasive, peripheral biomarker that would allow for a certain diagnosis of MDD. The objective of this paper is to use the receiver operating characteristic (ROC) analy...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2012.09.017
更新日期：2013-02-01 00:00:00
abstract：:'Behavioral contagion' refers to an increased tendency for a behavior to be performed when socially related persons have already performed it. So understood, behavioral contagion may be involved in criminality, conduct disorder, drug abuse, suicide, and teenage pregnancy. In a recent paper we showed that contagion, wh...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/0022-3956(94)90035-3
更新日期：1994-01-01 00:00:00
abstract：:We have studied the association between migraine and major depression in a group of 133 probands with major depression, a group of 82 normal community controls and 400 interviewed first-degree relatives of the probands and controls. There was a significant association between depression and migraine among both the pro...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/0022-3956(88)90076-3
更新日期：1988-01-01 00:00:00
abstract：:The cytomatrix active zone (CAZ) is a specialized cellular structure regulating release of vesicles. We reported previously increased expression of three CAZ genes, piccolo, RIMS2 and RIMS3 in the amygdala in schizophrenia. This study determined the levels of gene and protein expression for components of the active zo...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2008.04.001
更新日期：2009-01-01 00:00:00
abstract：:This study explored whether cerebral metabolic changes seen in treatment resistant and rapid cycling bipolar depression inpatients are also found in an outpatient sample not specifically selected for treatment resistance or rapid cycling. We assessed 15 depressed outpatients with bipolar disorder (six type I and nine ...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2008.04.015
更新日期：2009-01-01 00:00:00
abstract：:Borderline personality disorder (BPD) is marked by aggression and impulsive, often self-destructive behavior. Despite the severe risks associated with BPD, relatively little is known about the disorder's etiology. Identification of genetic correlates (endophenotypes) of BPD would improve the prospects of targeted inte...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2009.01.002
更新日期：2009-08-01 00:00:00
abstract：:Veterans have high rates of suicide, and nonsuicidal self-injury (NSSI) is one of the strongest predictors of suicide risk; however, there is presently little known about antecedents of NSSI that might inform intervention efforts. Accumulating research suggests that anger and hostility play an important role in NSSI, ...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2021.01.011
更新日期：2021-01-07 00:00:00
abstract：:Acute alcohol use is an important risk factor for attempted and completed suicide. We evaluated the effect of acute alcohol intake on the lethality of suicide attempts to test the hypothesis that acute alcohol intoxication is associated with more lethal suicide attempts. This retrospective study included 317 suicide a...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2009.01.005
更新日期：2009-07-01 00:00:00
abstract：:A number of lines of converging evidence suggest that brain-derived neurotrophic factor (BDNF) may play a role in the onset and treatment of bipolar disorder. We review pertinent data on BDNF from several different areas of preclinical and clinical investigation that suggest novel theoretical and treatment implication...
journal_title：Journal of psychiatric research
pub_type： 杂志文章,评审
doi：10.1016/j.jpsychires.2006.09.009
更新日期：2007-12-01 00:00:00
abstract：OBJECTIVE:To evaluate the efficacy of rEEG(®)-guided pharmacotherapy for the treatment of depression in those circumstances where rEEG and STAR*D provided different recommendations. MATERIALS AND METHODS:This was a randomized, single-blind, parallel group, 12 center, US study of rEEG-guided pharmacotherapy vs. the mos...
journal_title：Journal of psychiatric research
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.jpsychires.2010.05.009
更新日期：2011-01-01 00:00:00
abstract：:Psychiatric researchers grapple with concerns that individuals with mental illness may be less likely to appreciate risks of research participation, particularly compared to people not suffering from mental illness. Therefore, empirical studies that directly compare the perspectives of such individuals are needed. In ...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2019.12.010
更新日期：2020-03-01 00:00:00
abstract：:Several lines of evidence indicate that alterations in intracellular calcium homeostasis with sustained elevation of free calcium ions ([Ca2+]i) might be important in the pathophysiology of Alzheimer's disease (AD). Recent studies with peripheral blood-cells have demonstrated that investigation of regulatory mechanism...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/0022-3956(96)00001-5
更新日期：1996-05-01 00:00:00
abstract：:Cognitive deficits, which are core manifestations in schizophrenia and exhibit a limited response to antipsychotic treatment, contribute to poor treatment outcomes and functional disability. Evidence on the effect of aerobic walking (AW) and exercise intensity on cognitive function in patients with schizophrenia is la...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2020.12.062
更新日期：2020-12-24 00:00:00
abstract：:Narcissistic personality disorder is the subject of extensive discussion in the literature. Yet, the validity of this diagnostic category remains questionable. This is owed, in large part, to the relative absence of empirical work that has examined narcissism in clinical samples. Descriptions and findings from studies...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2008.12.005
更新日期：2009-06-01 00:00:00
abstract：BACKGROUND:Treatment-resistant major depressive disorder (MDD) is a complex condition, with very low remission rates. Physical exercise has been used, with some encouraging results, as an alternative therapy in other depressive disorders. This study assessed the impact on depression and functioning parameters of a mode...
journal_title：Journal of psychiatric research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jpsychires.2011.02.005
更新日期：2011-08-01 00:00:00
abstract：BACKGROUND:Resilience, the ability to adapt positively to adversity, may be an important factor in successful aging. However, the assessment and correlates of resilience in elderly individuals have not received adequate attention. METHOD:A total of 1395 community-dwelling women over age 60 who were participants at the...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2008.03.007
更新日期：2008-12-01 00:00:00
abstract：:To determine the role of genetics in bipolar affective disorders it was necessary to have correct diagnoses and large homogenous population(s). To identify a marker linked to the disease two additional factors were important, a correct model for genetic transmission and highly polymorphic DNA markers. With the establi...
journal_title：Journal of psychiatric research
pub_type： 杂志文章,评审
doi：10.1016/0022-3956(87)90106-3
更新日期：1987-01-01 00:00:00
abstract：:Generalized anxiety disorder (GAD) is highly prevalent among adolescents. An early detection of individuals at risk may prevent later psychiatric condition. Genome-wide studies investigating single nucleotide polymorphisms (SNPs) concluded that a focus on epigenetic mechanisms, which mediate the impact of environmenta...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2018.03.008
更新日期：2018-07-01 00:00:00
abstract：:A latent class analysis paradigm for evaluating and developing diagnostic criteria was presented. How latent class analysis statistically models the conceptual structure of diagnostic systems was demonstrated. These models were then used to study the Taylor and Abrams diagnostic criteria for schizophrenia. The finding...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/0022-3956(82)90007-3
更新日期：1982-01-01 00:00:00
abstract：:The purpose of this study was to delineate differences in inpatient service utilization and functional and subjective outcomes between veterans with a serious mental illness (SMI) and those with co-occurring serious mental illnesses and substance abuse (SA) disorders. This study assessed 2-year inpatient utilization a...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/s0022-3956(98)00015-6
更新日期：1998-09-01 00:00:00
abstract：:Schizophrenia patients have significant memory difficulties that have far-reaching implications in their daily life. These impairments are partly attributed to an inability to self-initiate effective memory encoding strategies, but its core neurobiological correlates remain unknown. The current study addresses this cr...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2017.02.024
更新日期：2017-08-01 00:00:00
abstract：OBJECTIVE:This study aims to better characterize the metabolic effects of antipsychotics in the early stage of treatment in first-episode patients with schizophrenia. METHODS:We performed a retrospective real-world study in a naturalistic setting that included inpatients with first-episode drug-naïve schizophrenia; me...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2020.07.038
更新日期：2020-10-01 00:00:00
abstract：:Although self-harm has been observed among patients with eating disorders, the effects of such tendencies on treatment outcomes are unclear. The current study employed structural equation modeling to (a) evaluate the relationship between self-harm and changes in body dissatisfaction and drive for thinness in a large s...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2015.03.016
更新日期：2015-06-01 00:00:00
abstract：:Previous studies examining the association between schizophrenia and pain have produced mixed results and data on sub-threshold psychosis or psychotic symptoms and pain are scarce. This study assessed the association between psychosis and severe pain among community-dwelling adults in 44 low- and middle-income countri...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2015.07.020
更新日期：2015-10-01 00:00:00
abstract：:In a study designed to assess the effects of short-term food deprivation on cognitive function, a sample of female subjects (N = 21) was tested on a number of measures of cognitive function after three levels of food deprivation (miss one meal, miss two meals or miss all food for 24 h prior to testing) and a condition...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/0022-3956(95)00009-t
更新日期：1995-05-01 00:00:00
