当前位置： SCI文献检索 > JOURNAL OF PSYCHIATRIC RESEARCH期刊下所有文献 > Neural correlates of emotional processing in depression: changes with cognitive behavioral therapy and predictors of treatment response.

Neural correlates of emotional processing in depression: changes with cognitive behavioral therapy and predictors of treatment response.

Abstract：

:Major depressive disorder (MDD) is characterized by the presence of disturbances in emotional processing. However, the neural correlates of these alterations, and how they may be affected by therapeutic interventions, remain unclear. The present study addressed these issues in a preliminary investigation using functional magnetic resonance imaging (fMRI) to examine neural responses to positive, negative, and neutral pictures in unmedicated MDD patients (N = 22) versus controls (N = 14). After this initial scan, MDD patients were treated with cognitive behavioral therapy (CBT) and scanned again after treatment. Within regions that showed pre-treatment differences between patients and controls, we tested the association between pre-treatment activity and subsequent treatment response as well as activity changes from pre- to post-treatment. This study yielded three main findings. First, prior to treatment and relative to controls, patients exhibited overall reduced activity in the ventromedial prefrontal cortex (PFC), diminished discrimination between emotional and neutral items in the amygdala, caudate, and hippocampus, and enhanced responses to negative versus positive stimuli in the left anterior temporal lobe (ATL) and right dorsolateral PFC. Second, CBT-related symptom improvement in MDD patients was predicted by increased activity at baseline in ventromedial PFC as well as the valence effects in the ATL and dorsolateral PFC. Third, from pre- to post-treatment, MDD patients exhibited overall increases in ventromedial PFC activation, enhanced arousal responses in the amygdala, caudate, and hippocampus, and a reversal of valence effects in the ATL. The study was limited by the relatively small sample that was able to complete both scan sessions, as well as an inability to determine the influence of comorbid disorders within the current sample. Nevertheless, components of the neural networks corresponding to emotion processing disturbances in MDD appear to resolve following treatment and are predictive of treatment response, possibly reflecting improvements in emotion regulation processes in response to CBT.

journal_name

J Psychiatr Res

journal_title

Journal of psychiatric research

authors

Ritchey M,Dolcos F,Eddington KM,Strauman TJ,Cabeza R

doi

10.1016/j.jpsychires.2010.09.007

subject

Has Abstract

pub_date

2011-05-01 00:00:00

pages

577-87

issue

eissn

0022-3956

issn

1879-1379

pii

S0022-3956(10)00274-8

journal_volume

pub_type

临床试验,杂志文章

在线工具

Neural correlates of emotional processing in depression: changes with cognitive behavioral therapy and predictors of treatment response.