Abstract：
:Twenty-six psychoneurotic inpatients received oxazepam (60-120 mg daily) or placebo for one to two weeks. The strongest evidence for the superiority of oxazepam over placebo was that a greater proportion of oxazepam-treated patients remained on the study the full two weeks than placebo-treated patients. Patients' self-evaluations on the MMPI also favored oxazepam. Behavioral ratings by clinicians and ward personnel on the BPRS, symptom checklist, and assessment of global disorder did not discriminate the active drug from placebo as well as self-ratings did. Most of the differences found favored oxazepam, although some failed to reach acceptable levels of significance. It is suggested that the relative similarity of neurotic individuals to normal individuals with respect to pathology (e.g. anxiety, tension, depression) and difficulties in life and that the subjectivity of experience and the absence of gross and easily demonstrable symptoms make evaluation of improvement difficult. Symptom measurement on behavioral rating devices is probably less effective in discriminating drug-placebo differences in neurotic syndromes than in psychotic syndromes.
journal_name
J Psychiatr Resjournal_title
Journal of psychiatric researchauthors
Janecek J,Vestre ND,Schiele BC,Zimmermann Rdoi
10.1016/0022-3956(66)90007-0subject
Has Abstractpub_date
1966-12-01 00:00:00pages
199-206issue
3eissn
0022-3956issn
1879-1379journal_volume
4pub_type
杂志文章,随机对照试验abstract：:Diagnosing major depressive disorder (MDD) continues to be based on meeting phenomenological and descriptive criteria. As of yet, there is still no non-invasive, peripheral biomarker that would allow for a certain diagnosis of MDD. The objective of this paper is to use the receiver operating characteristic (ROC) analy...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2012.09.017
更新日期：2013-02-01 00:00:00
abstract：OBJECTIVE:To investigate possible differences in peripheral levels of chemokines, BDNF and oxidative markers between patients with Schizophrenia (SZ) and matched healthy controls, and investigate the correlation of these biomarkers with cognitive performance. METHODS:Thirty individuals with SZ and 27 healthy controls ...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2013.05.032
更新日期：2013-10-01 00:00:00
abstract：:Many psychiatric patients have a minor blood-CSF barrier dysfunction and increased Cerebrospinal fluid (CSF) neopterin concentrations. The source of normal CSF neopterin, a biomarker in inflammatory and non-inflammatory neurological diseases, has never been shown explicitly, a precondition for sensitive detection of p...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2013.05.027
更新日期：2013-10-01 00:00:00
abstract：BACKGROUND:Bipolar disorder may be associated with peripheral immune system dysfunction; however, results in individual studies are conflicting. Our aim was to systematically review evidence of peripheral cytokine alterations in bipolar disorder integrating findings from various affective states. METHODS:We conducted ...
journal_title：Journal of psychiatric research
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.jpsychires.2013.05.018
更新日期：2013-09-01 00:00:00
abstract：OBJECTIVES:Dysfunctions in stress biology are hypothesized to contribute to anxiety disorders, and to be ameliorated during successful treatment, but limited clinical data exist to support this hypothesis. We evaluated whether increases in morning cortisol and the diurnal cortisol slope, markers of stress biology, are ...
journal_title：Journal of psychiatric research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jpsychires.2017.10.011
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:Various studies of child cortisol secretion and sleep show a close association between poor sleep, deterioration of the HPA axis and unfavorable psychological functioning. However, there is little evidence as to whether these associations are clearly present in pre-school children suffering from psychiatric ...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2012.01.018
更新日期：2012-05-01 00:00:00
abstract：:Although fears of negative and positive social evaluation are hallmark cognitive features of social anxiety, attentional difficulties may exacerbate the relation between fears of social evaluation and social anxiety. Thus, the goal of the current study was to test whether two different types of self-reported attention...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2020.08.030
更新日期：2020-12-01 00:00:00
abstract：:Prevalence figures of depression usually show a sex ratio for males:females of 1:2. This unequal ratio has been examined by varying the time periods for the calculation of prevalance rates and the criteria for case definition. Based on results of a 20-23 yr-old cohort of 591 males and females studied in Switzerland, s...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/0022-3956(84)90029-3
更新日期：1984-01-01 00:00:00
abstract：:Antidepressant treatment for major depressive disorder remains suboptimal with response rates of just over 50%. Although treatment guidelines, algorithms and clinical keys are available to assist the clinician, the process of finding an effective pharmacotherapy to maximise benefit for the individual patient is largel...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2016.08.020
更新日期：2016-12-01 00:00:00
abstract：:Suicide plans are a major risk factor for suicide, which is a devastating outcome of depression. While structural and functional brain changes have been demonstrated in relation to suicidal thoughts and behaviour, brain mechanisms underlying suicide plans have not yet been studied. Here, we studied changes in regional...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2016.10.011
更新日期：2017-01-01 00:00:00
abstract：OBJECTIVES:The DEX/CRH test has been proposed to be suitable as a biomarker for the prediction of treatment response in depression. METHODS:We performed the DEX/CRH test in 10 severely depressed male patients with melancholic features before initiation of antidepressant treatment with 20 mg fluoxetine. RESULTS:We fou...
journal_title：Journal of psychiatric research
pub_type： 临床试验,杂志文章
doi：10.1016/j.jpsychires.2010.04.010
更新日期：2010-12-01 00:00:00
abstract：:The concentrations of amino acids in the cerebrospinal fluid (CSF) were measured in pairs of healthy mono- and dizygotic twins. Intraclass correlations were calculated. Genetic and cultural heritabilities were estimated using a path analytical model. CSF levels of glycine, tyrosine and arginine were shown to be influe...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/0022-3956(88)90028-3
更新日期：1988-01-01 00:00:00
abstract：:Childhood maltreatment is associated with posttraumatic stress disorder (PTSD) and elevated rates of adolescent and adult psychopathology including major depression, bipolar disorder, substance use disorders, and other medical comorbidities. Gray matter volume changes have been found in maltreated youth with (versus w...
journal_title：Journal of psychiatric research
pub_type： 杂志文章,多中心研究
doi：10.1016/j.jpsychires.2017.12.015
更新日期：2018-03-01 00:00:00
abstract：:A substantial number of studies have demonstrated increased imidazoline receptors (I1 binding sites) on platelets of depressed patients and downregulation following antidepressant treatments. Herein, imidazoline receptor binding protein (IRBP) antiserum was used to quantify imidazoline receptors on platelets of depres...
journal_title：Journal of psychiatric research
pub_type： 临床试验,杂志文章
doi：10.1016/s0022-3956(99)00009-6
更新日期：1999-07-01 00:00:00
abstract：:Identifying the profile of risky behaviors among drivers is central to propose effective interventions. Due to the multidimensional and overlapping aspects of risky driving behaviors, cluster analysis can provide additional insights in order to identify specific subgroups of risk. This study aimed to identify clusters...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2020.11.025
更新日期：2020-11-12 00:00:00
abstract：:Women with postnatal depression (PND) appear to have abnormal hypothalamic pituitary adrenal (HPA) axis responses to stress, which might involve a genetic variability component. We investigated association of genetic variants in the glucocorticoid receptor (GR, NR3C1) and corticotropin releasing hormone receptor 1 (CR...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2013.05.003
更新日期：2013-09-01 00:00:00
abstract：UNLABELLED:This prospective study aimed to assess symptomatic evolution of patients diagnosed with Upper Airway Resistance Syndrome (UARS) four and half years after the initial UARS diagnosis. For this purpose, 138 UARS patients were contacted by mail between 43 and 69 months after the initial evaluation; 105 responded...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2005.03.007
更新日期：2006-04-01 00:00:00
abstract：:Existing animal and human research support the causal role of stress in the emergence of anhedonia, and in turn, the influence of anhedonia in social functioning. However, this model has not been tested in relation to psychosis-risk; this literature gap is notable given that both anhedonia and declining social functio...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2021.01.005
更新日期：2021-01-11 00:00:00
abstract：BACKGROUND:Chronic users of cannabis often report withdrawal symptoms after abstinence from use, but little is known about cannabis withdrawal in people with schizophrenia. METHODS:Cannabis use patterns and withdrawal symptoms in adults with schizophrenia who had at least weekly cannabis use before attempting to quit ...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2012.10.010
更新日期：2013-02-01 00:00:00
abstract：:Utilizing the DSM-III-R schema, we have investigated lifetime comorbidity between panic disorder with or without agoraphobia (PD), social phobia (SP) and obsessive-compulsive disorder (OCD) on the one hand, and mood disorder on the other. Compared with PD, the results for SP and OCD showed significantly higher numbers...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/s0022-3956(98)00044-2
更新日期：1999-01-01 00:00:00
abstract：:One of the most characteristic alterations in depression is a disturbed regulation of the hypothalamic-pituitary-adrenocortical (HPA) system. A function test combining the pre-treatment of 1.5 mg dexamethasone (DEX) with a challenge of 100 microg corticotropin-releasing hormone (CRH) reveals a pathological increase in...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2004.04.009
更新日期：2005-01-01 00:00:00
abstract：BACKGROUND:Schizophrenia research has gained a new focus on identification and further characterization of neurocognitive deficits in the search for behavioural endophenotypes of this disorder. The objective of this study was to explore differential cortical processing during executive control in schizophrenia as asses...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2006.06.012
更新日期：2007-10-01 00:00:00
abstract：:The cytomatrix active zone (CAZ) is a specialized cellular structure regulating release of vesicles. We reported previously increased expression of three CAZ genes, piccolo, RIMS2 and RIMS3 in the amygdala in schizophrenia. This study determined the levels of gene and protein expression for components of the active zo...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2008.04.001
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND:Motivational impairments are a core feature of schizophrenia and although there are numerous reports studying this feature using clinical rating scales, objective behavioural assessments are lacking. Here, we use a translational paradigm to measure incentive motivation in individuals with schizophrenia. MET...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2013.08.003
更新日期：2013-11-01 00:00:00
abstract：:We performed a systematic review and meta-analysis of the efficacy and safety of second generation (SG) long-acting antipsychotics (LAIAs) versus first generation (FG) LAIAs in schizophrenia. We conducted a comprehensive search in PubMed, MEDLINE, EMBASE and PsycINFO until May 2019. Inclusion criteria for randomized t...
journal_title：Journal of psychiatric research
pub_type： 杂志文章,评审
doi：10.1016/j.jpsychires.2020.06.013
更新日期：2020-10-01 00:00:00
abstract：:During the evening of 13 November 2015, the deadliest terror attacks in France in recent times occurred in the Paris area. Overall, 130 people were killed, 643 were physically injured and several thousands were psychologically impacted. Thousands of first responders, including health professionals, firefighters, affil...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2019.11.018
更新日期：2020-02-01 00:00:00
abstract：:The concept that schizophrenia has its antecedents in neurodevelopment has long been debated and has been at the forefront of research on this disorder over the last decade. However new recent evidence from controlled longitudinal studies indicates that some of the structural brain anomalies observed in schizophrenia ...
journal_title：Journal of psychiatric research
pub_type： 杂志文章,评审
doi：10.1016/s0022-3956(99)00028-x
更新日期：1999-11-01 00:00:00
abstract：:Acute alcohol use is an important risk factor for attempted and completed suicide. We evaluated the effect of acute alcohol intake on the lethality of suicide attempts to test the hypothesis that acute alcohol intoxication is associated with more lethal suicide attempts. This retrospective study included 317 suicide a...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2009.01.005
更新日期：2009-07-01 00:00:00
abstract：OBJECTIVE:Diffusion magnetic resonance imaging (dMRI) enables non-invasive characterization of white matter (WM) structures in vivo. Prior studies suggest that certain WM tracts may be affected in major depressive disorder (MDD), however, hippocampal subfield-specific dMRI measures have not yet been explored in MDD. We...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2019.02.008
更新日期：2019-04-01 00:00:00
abstract：:We compared unipolar depressed patients (N = 32) with normal controls (N = 38) for their prolactin responses on the thyrotropin releasing hormone test. Depressed patients showed prolactin responses similar to sex matched controls. Among the depressed patients there were no significant differences for prolactin respons...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/0022-3956(88)90007-6
更新日期：1988-01-01 00:00:00
