Abstract：
:Women with postnatal depression (PND) appear to have abnormal hypothalamic pituitary adrenal (HPA) axis responses to stress, which might involve a genetic variability component. We investigated association of genetic variants in the glucocorticoid receptor (GR, NR3C1) and corticotropin releasing hormone receptor 1 (CRHR1) genes with increased risk for PND. Two hundred pregnant women were recruited prospectively and PND risk was assessed by the Edinburgh Postnatal Depression Scale (EPDS) during pregnancy and again 2-8 weeks post-natally (CW-GAPND study). The BclI and ER22/23EK single nucleotide polymorphisms (SNPs) of the GR and the haplotype-tagged rs1876828, rs242939 and rs242941 SNPs of the CRHR1 associated with genetic risk to depressive disorders were genotyped. A cut-off score of 10 was used to detect increased risk of PND. Association analysis was carried out in 140 patients that completed the study protocol. The BclI and rs242939 SNPs were over-represented in women with postnatal EPDS score ≥10 with significant allele association (p = 0.011 and <0.001, respectively) and risk ratios of 2.9 (95% CI: 1.2-6.9) for BclI, 4.9 (2-12) for rs242939 and 5.48 (2.13-14.10) for both. The rs242939 SNP was also associated with increased EPDS values during pregnancy. Moreover, the G-G-T haplotype of the CRHR1 was significantly over-represented in patients with high EPDS scores, with risk ratio of 3.22 (95% CI: 1.91-5.42). This is the first evidence that specific SNPs of genes involved in 'stress' responses might contribute in the genetics of high-risk for depression during pregnancy and postpartum.
journal_name
J Psychiatr Resjournal_title
Journal of psychiatric researchauthors
Engineer N,Darwin L,Nishigandh D,Ngianga-Bakwin K,Smith SC,Grammatopoulos DKdoi
10.1016/j.jpsychires.2013.05.003subject
Has Abstractpub_date
2013-09-01 00:00:00pages
1166-73issue
9eissn
0022-3956issn
1879-1379pii
S0022-3956(13)00143-Xjournal_volume
47pub_type
杂志文章abstract：:A brief overview is given of the history of psychiatric nosology during the last 150 years. The varying role of genetics for theories of nosology is described. Classifications of mental disorders, more or less based on nosological concepts, are mentioned, as well as the recent emphasis on operational tools for classif...
journal_title：Journal of psychiatric research
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abstract：:The aim of this study was to estimate suicide risk during hospitalization and in the year following discharge for patients with mental disorders. All suicide cases in Sweden 18 years and older, between 1991 and 2003 (N=20,675; 70% male), were individually matched to 10 controls from the general Swedish population. Dis...
journal_title：Journal of psychiatric research
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journal_title：Journal of psychiatric research
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journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2015.04.017
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journal_title：Journal of psychiatric research
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Journal of psychiatric research
pub_type： 杂志文章
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journal_title：Journal of psychiatric research
pub_type： 杂志文章
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更新日期：2007-01-01 00:00:00
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journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2008.12.005
更新日期：2009-06-01 00:00:00
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journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2013.03.012
更新日期：2013-07-01 00:00:00
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journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2013.01.015
更新日期：2013-06-01 00:00:00
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journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2015.02.006
更新日期：2015-04-01 00:00:00
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journal_title：Journal of psychiatric research
pub_type： 杂志文章,meta分析
doi：10.1016/j.jpsychires.2015.12.016
更新日期：2016-03-01 00:00:00
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journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2019.05.017
更新日期：2019-08-01 00:00:00
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journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2019.01.006
更新日期：2019-04-01 00:00:00
abstract：:There is evidence that rates of major depression have increased over this century, with successive birth cohorts showing increased lifetime risks and earlier ages of onset. Two memory effects have been considered possible artifactual causes of these trends: age-related forgetting and postdating early episodes. In this...
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pub_type： 杂志文章
doi：10.1016/0022-3956(91)90007-w
更新日期：1991-01-01 00:00:00
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journal_title：Journal of psychiatric research
pub_type： 杂志文章
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journal_title：Journal of psychiatric research
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journal_title：Journal of psychiatric research
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2020-05-01 00:00:00
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pub_type： 临床试验,杂志文章
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更新日期：1999-05-01 00:00:00
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journal_title：Journal of psychiatric research
pub_type： 杂志文章,随机对照试验
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更新日期：2018-01-01 00:00:00
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journal_title：Journal of psychiatric research
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2004-09-01 00:00:00
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journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2010.05.015
更新日期：2011-02-01 00:00:00
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journal_title：Journal of psychiatric research
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期：2004-05-01 00:00:00
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journal_title：Journal of psychiatric research
pub_type： 杂志文章
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更新日期：2020-02-01 00:00:00
abstract：:Temperamental features are strongly associated with suicidal behaviors both in general population and clinical samples. In the present study we considered the association between personality traits, measured by Temperament and Character Inventory (TCI), and suicidal behavior. We analyzed five samples: a German control...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2007.10.006
更新日期：2008-09-01 00:00:00
abstract：:Reports have described how psychiatric patients respond to disasters. However, previous reports on the response depending on diagnostic categories have provided no clear consensus. Here we analyzed response to the Great East Japan Earthquake of March 11, 2011, among psychiatric patients in light of severity of pre-exi...
journal_title：Journal of psychiatric research
pub_type： 杂志文章
doi：10.1016/j.jpsychires.2013.06.006
更新日期：2013-10-01 00:00:00
