Distinct neural responses used to gain insight into hallucinatory perception in patients with schizophrenia.

Abstract:

OBJECTIVE:Most patients with schizophrenia suffer from various types of hallucinations, which commonly produce distress, functional disability or behavioral dyscontrol. The neural process of adapting to hallucinations in patients with schizophrenia remains unknown. METHODS:Functional magnetic resonance imaging (MRI) responses to an unusual threatening visual stimulus designed to simulate a hallucinatory experience were compared between 16 patients with schizophrenia and 17 healthy controls. Linear and quadratic repetition-variant as well as repetition-invariant responses to the stimulus were compared between the two groups. RESULTS:Repetition-invariant responses were similar between patients with schizophrenia and healthy controls. Patients with schizophrenia exhibited a linear activation pattern in the anterior cingulate, whereas healthy controls exhibited a parabolic activation pattern in the anterior prefrontal cortex, occipito-temporal junction and amygdala. CONCLUSIONS:These results provide us with a better understanding of the neural processes involved in gaining insight into unreality. Patients with schizophrenia may use a salience-related region instead of reality monitoring-related regions to react to the unusual stimuli, and this peculiarity of the neural processes may be related to vulnerability to psychosis.

journal_name

J Psychiatr Res

authors

Kim JJ,Ku J,Lee H,Choi SH,Kim IY

doi

10.1016/j.jpsychires.2012.06.012

subject

Has Abstract

pub_date

2012-10-01 00:00:00

pages

1318-25

issue

10

eissn

0022-3956

issn

1879-1379

pii

S0022-3956(12)00194-X

journal_volume

46

pub_type

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