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Incentive motivation deficits in schizophrenia reflect effort computation impairments during cost-benefit decision-making.

Abstract：

BACKGROUND:Motivational impairments are a core feature of schizophrenia and although there are numerous reports studying this feature using clinical rating scales, objective behavioural assessments are lacking. Here, we use a translational paradigm to measure incentive motivation in individuals with schizophrenia. METHODS:Sixteen stable outpatients with schizophrenia and sixteen matched healthy controls completed a modified version of the Effort Expenditure for Rewards Task that accounts for differences in motoric ability. Briefly, subjects were presented with a series of trials where they may choose to expend a greater amount of effort for a larger monetary reward versus less effort for a smaller reward. Additionally, the probability of receiving money for a given trial was varied at 12%, 50% and 88%. Clinical and other reward-related variables were also evaluated. RESULTS:Patients opted to expend greater effort significantly less than controls for trials of high, but uncertain (i.e. 50% and 88% probability) incentive value, which was related to amotivation and neurocognitive deficits. Other abnormalities were also noted but were related to different clinical variables such as impulsivity (low reward and 12% probability). These motivational deficits were not due to group differences in reward learning, reward valuation or hedonic capacity. CONCLUSIONS:Our findings offer novel support for incentive motivation deficits in schizophrenia. Clinical amotivation is associated with impairments in the computation of effort during cost-benefit decision-making. This objective translational paradigm may guide future investigations of the neural circuitry underlying these motivational impairments.

journal_name

J Psychiatr Res

journal_title

Journal of psychiatric research

authors

Fervaha G,Graff-Guerrero A,Zakzanis KK,Foussias G,Agid O,Remington G

doi

10.1016/j.jpsychires.2013.08.003

subject

Has Abstract

pub_date

2013-11-01 00:00:00

pages

1590-6

issue

11

eissn

0022-3956

issn

1879-1379

pii

S0022-3956(13)00254-9

journal_volume

47

pub_type

杂志文章

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