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ABCB1 gene polymorphisms and violent suicide attempt among survivors.

Abstract：

INTRODUCTION:Those suicide attempters that choose violent methods dramatically diminish the possibility of survival. Completed suicide using violent means, which is common among first-time suicide attempters, was recently found to be more likely among T allele carriers in the three most common ABCB1 SNPs, encoding for P-gp. Thus, this study examined, for the first time, whether these ABCB1 SNPs were associated with the use of violent means among survivors of a suicide attempt. MATERIAL AND METHODS:Suicide attempters (n = 578, 87.4% women; of whom 16.6% committed a violent intent) were genotyped for exonic SNPs in the ABCB1 (C1236T, G2677T/A, C3435T). The relations of the three genotypes and of the TTT haplotype with the use of a violent suicide method were evaluated separately. The impact of confounds on these variables was controlled. RESULTS:A higher frequency (p = 0.02) of suicide attempters using violent methods was found among those carrying the ABCB1 haplotype (1236TT-2677TT-3435TT). Since gender and number of previous suicide attempts were identified as confounds, the relation was tested in the subset of women who were first-time attempters or second- and more-time attempters. The ABCB1 haplotype increased the risk more than three times in those women attempting a violent suicide for the first time (OR = 3.6; CI95%: 1.08-12.09; p = 0.04). DISCUSSION:The ABCB1 haplotype (1236TT-2677TT-3435TT) was related to the use of a violent suicide attempt method. Genotyping for these three ABCB1 SNPs may be helpful to detect people at risk of first suicide intents using violent methods.

journal_name

J Psychiatr Res

journal_title

Journal of psychiatric research

authors

Peñas-Lledó E,Guillaume S,Delgado A,Naranjo ME,Jaussent I,LLerena A,Courtet P

doi

10.1016/j.jpsychires.2014.12.005

subject

Has Abstract

pub_date

2015-02-01 00:00:00

pages

52-6

eissn

0022-3956

issn

1879-1379

pii

S0022-3956(14)00346-X

journal_volume

61

pub_type

杂志文章

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