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The effect of elevated systemic cortisol levels on plasma catecholamines in Cushing's syndrome patients with and without depressed mood.

Abstract：

:This study explored the effect of elevated systemic cortisol levels on plasma epinephrine and norepinephrine, and hemodynamic variables, in patients with active Cushing's syndrome; ratings of depressed mood were also obtained. Norepinephrine levels were significantly negatively correlated with 24 h urinary free cortisol levels. Cushing's patients without depressed mood showed more robust negative correlations than those with depressed mood. The inverse relationship between norepinephrine and cortisol is consistent with data obtained previously in acute studies of normal subjects. Mechanisms which might explain these relationships include changes in control of catecholamine production, release, and or metabolic clearance in Cushing's patients. The decrease in the strength of association in depressed Cushing's patients is consistent with prior studies that suggest abnormal relationships between hypothalamic-pituitary-adrenocortical activity and noradrenergic function in major depressive disorder.

journal_name

J Psychiatr Res

journal_title

Journal of psychiatric research

authors

Cameron OG,Starkman MN,Schteingart DE

doi

10.1016/0022-3956(95)00017-y

subject

Has Abstract

pub_date

1995-09-01 00:00:00

pages

347-60

issue

5

eissn

0022-3956

issn

1879-1379

pii

0022-3956(95)00017-Y

journal_volume

29

pub_type

杂志文章

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