当前位置： SCI文献检索 > JOURNAL OF PSYCHIATRIC RESEARCH期刊下所有文献 > The 12-year trend report of antipsychotic usage in a nationwide claims database derived from four million people in Japan.

The 12-year trend report of antipsychotic usage in a nationwide claims database derived from four million people in Japan.

Abstract：

:The current study aimed to describe the use of antipsychotics to clarify the gap between clinical guidelines and health care practice in Japan. We used data from the JMDC Claims Database (JMDC Inc., Tokyo, Japan), a nationwide claims database, from 2005 to 2016. Antipsychotics were defined as drugs coded as N05A with the Anatomical Therapeutic and Chemical (ATC) codes. We described the annual changes in proportions based on the number of patients prescribed any antipsychotics. From the database of 4,081,102 people, the data of 12,382 patients was extracted by applying the following exclusion criteria: no use of antipsychotics, missing the prescription date or dose, inpatients, prescribed antipsychotics only for use as needed, prescribed only injectable antipsychotics except for long-acting injections (LAIs), without schizophrenia as the primary disease, not exceeding 75 mg/day chlorpromazine equivalent, and less than 18 years old. The use of second-generation antipsychotics (SGA) has been expanding, while the use of first-generation antipsychotics has been decreasing. Aripiprazole accounted for the highest proportion of prescribed antipsychotics (31.9%) in 2016. Even though clozapine is categorized as a SGA, it accounted for a paltry 0.2%. The proportion of prescribed antipsychotics accounted for by LAIs was less than 5%. Although the use of antipsychotics for schizophrenia in Japan mostly corresponds to various clinical guidelines, limited use of clozapine and LAIs was identified. Further research focusing on the factors affecting the prescription of these underused antipsychotics may help advance the pharmacological therapy of schizophrenia.

journal_name

J Psychiatr Res

journal_title

Journal of psychiatric research

authors

Hata T,Kanazawa T,Hamada T,Nishihara M,Yoneda H,Nakajima M,Katsumata T

doi

10.1016/j.jpsychires.2020.05.012

subject

Has Abstract

pub_date

2020-08-01 00:00:00

pages

28-34

eissn

0022-3956

issn

1879-1379

pii

S0022-3956(20)30256-9

journal_volume

127

pub_type

杂志文章

相关文献

JOURNAL OF PSYCHIATRIC RESEARCH文献大全
  • Decoding rumination: A machine learning approach to a transdiagnostic sample of outpatients with anxiety, mood and psychotic disorders.

    abstract：OBJECTIVE:To employ machine learning algorithms to examine patterns of rumination from RDoC perspective and to determine which variables predict high levels of maladaptive rumination across a transdiagnostic sample. METHOD:Sample of 200 consecutive, consenting outpatient referrals with clinical diagnoses of schizophre...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2019.12.005

    authors： Silveira ÉM Júnior,Passos IC,Scott J,Bristot G,Scotton E,Teixeira Mendes LS,Umpierre Knackfuss AC,Gerchmann L,Fijtman A,Trasel AR,Salum GA,Kauer-Sant'Anna M

    更新日期：2020-02-01 00:00:00

  • A comparative analysis between site-based and centralized ratings and patient self-ratings in a clinical trial of Major Depressive Disorder.

    abstract：:We compared scores from three different ratings methods in a clinical trial of patients with Major Depressive Disorder (MDD). The Quick Inventory of Depressive Symptoms (QIDS-SR16) was compared to site-based clinician and centralized (site-independent) ratings of the Inventory of Depressive Symptoms (IDSc30). An extra...

    journal_title：Journal of psychiatric research

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.jpsychires.2013.02.016

    authors： Targum SD,Wedel PC,Robinson J,Daniel DG,Busner J,Bleicher LS,Rauh P,Barlow C

    更新日期：2013-07-01 00:00:00

  • HLA in psychiatric and control subjects. A comparative study of HLA antigen frequencies in schizophrenic, schizoaffective and control subjects.

    abstract：:HLA antigens were typed among 24 schizophrenic, 13 schizoaffective and 246 control subjects. Schizoaffective patients showed significantly decreased incidence of A2 compared with schizophrenic patients or controls. ...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/0022-3956(85)90076-7

    authors： Adler S,Vasile RG,Yunis E,Shapiro R

    更新日期：1985-01-01 00:00:00

  • Side-effects of SSRIs disrupt multimodal treatment for pediatric OCD in a randomized-controlled trial.

    abstract：OBJECTIVE:Activation Syndrome (AS) is a side-effect of antidepressants consisting of irritability, mania, self-harm, akathisia, and disinhibition. The current study was conducted to analyze how AS may hinder treatment outcome for multimodal treatment for children and adolescents with Obsessive-Compulsive Disorder. MET...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.jpsychires.2015.10.006

    authors： Reid AM,McNamara JP,Murphy TK,Guzick AG,Storch EA,Goodman WK,Geffken GR,Bussing R

    更新日期：2015-12-01 00:00:00

  • Structural covariance network centrality in maltreated youth with posttraumatic stress disorder.

    abstract：:Childhood maltreatment is associated with posttraumatic stress disorder (PTSD) and elevated rates of adolescent and adult psychopathology including major depression, bipolar disorder, substance use disorders, and other medical comorbidities. Gray matter volume changes have been found in maltreated youth with (versus w...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jpsychires.2017.12.015

    authors： Sun D,Peverill MR,Swanson CS,McLaughlin KA,Morey RA

    更新日期：2018-03-01 00:00:00

  • Diffusion abnormalities in adolescents and young adults with a history of heavy cannabis use.

    abstract：BACKGROUND:There is growing evidence that adolescence is a key period for neuronal maturation. Despite the high prevalence of marijuana use among adolescents and young adults in the United States and internationally, very little is known about its impact on the developing brain. Based on neuroimaging literature on norm...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2008.12.002

    authors： Ashtari M,Cervellione K,Cottone J,Ardekani BA,Sevy S,Kumra S

    更新日期：2009-01-01 00:00:00

  • Antidepressants act on glial cells: SSRIs and serotonin elicit astrocyte calcium signaling in the mouse prefrontal cortex.

    abstract：:One important target in the treatment of major depressive disorder (MDD) is the serotonin (5-hydroxytryptamine, 5-HT) system. Selective serotonin reuptake inhibitors (SSRI) are used to treat MDD. Yet, the mode of action of these drugs is not completely understood. There is evolving evidence for a role of glutamate in ...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2010.06.005

    authors： Schipke CG,Heuser I,Peters O

    更新日期：2011-02-01 00:00:00

  • Neuropsychological profile in patients with obsessive-compulsive disorder over a period of 4-month treatment.

    abstract：:This study investigated the changes of the neuropsychological functions over a 4-month period of treatment in patients with obsessive-compulsive disorder (OCD). Thirty-nine OCD patients and 31 healthy controls were evaluated with neuropsychological and clinical tests. The same tests were readministered 4-months after ...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/s0022-3956(02)00017-1

    authors： Kim MS,Park SJ,Shin MS,Kwon JS

    更新日期：2002-07-01 00:00:00

  • Early score fluctuation and placebo response in a study of major depressive disorder.

    abstract：:Early score fluctuation in double-blind, placebo-controlled studies may affect the reliability of the baseline measurement and adversely affect the eventual study outcome. We examined the effect of early score fluctuation during a 2-week double-blind placebo lead-in period in a phase II, double-blind, placebo-controll...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2019.11.014

    authors： Targum SD,Cameron BR,Ferreira L,MacDonald ID

    更新日期：2020-02-01 00:00:00

  • Fast BDNF serum level increase and diurnal BDNF oscillations are associated with therapeutic response after partial sleep deprivation.

    abstract：OBJECTIVE:Preclinical and clinical studies support a role for brain-derived neurotrophic factor (BDNF) in the pathophysiology of stress-related mood disorders. Furthermore, BDNF seems to be linked to antidepressant action. Available pharmacological treatments for depression are characterized by significant limitations ...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2014.09.005

    authors： Giese M,Beck J,Brand S,Muheim F,Hemmeter U,Hatzinger M,Holsboer-Trachsler E,Eckert A

    更新日期：2014-12-01 00:00:00

  • Effects of gustatory stimulation on brain activity during hunger and satiety in females with restricting-type anorexia nervosa: an fMRI study.

    abstract：BACKGROUND:Previous research has demonstrated altered neuronal responses to visual stimulation with food in anorexia nervosa, varying with the motivational state of hunger or satiety. The aim of the present fMRI study was to assess hunger- and satiety-dependent alterations in the gustatory processing of stimulation wit...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2010.07.012

    authors： Vocks S,Herpertz S,Rosenberger C,Senf W,Gizewski ER

    更新日期：2011-03-01 00:00:00

  • Pregnancy risk factors in relation to oppositional-defiant and conduct disorder symptoms in the Avon Longitudinal Study of Parents and Children.

    abstract：BACKGROUND:Pregnancy factors have been implicated in offspring oppositional-defiant disorder (ODD) and conduct disorder (CD) symptoms. Literature still holds notable limitations, such as studying only a restricted set of pregnancy factors, use of screening questionnaires which assess broadly defined outcome measures, a...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2018.02.020

    authors： Ruisch IH,Buitelaar JK,Glennon JC,Hoekstra PJ,Dietrich A

    更新日期：2018-06-01 00:00:00

  • Effects of doxycycline on depressive-like behavior in mice after lipopolysaccharide (LPS) administration.

    abstract：:Current evidences support inflammation, oxidative and nitrogen stress, as well as brain-derived neurotrophic factor (BDNF) signaling mechanisms as important in depression pathophysiology. Tetracycline antibiotics have anti-inflammatory and antioxidant properties. Preliminary evidence indicates that minocycline has ant...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.jpsychires.2013.06.008

    authors： Mello BS,Monte AS,McIntyre RS,Soczynska JK,Custódio CS,Cordeiro RC,Chaves JH,Vasconcelos SM,Nobre HV Jr,Florenço de Sousa FC,Hyphantis TN,Carvalho AF,Macêdo DS

    更新日期：2013-10-01 00:00:00

  • Evaluation of behavioral impulsivity and aggression tasks as endophenotypes for borderline personality disorder.

    abstract：:Borderline personality disorder (BPD) is marked by aggression and impulsive, often self-destructive behavior. Despite the severe risks associated with BPD, relatively little is known about the disorder's etiology. Identification of genetic correlates (endophenotypes) of BPD would improve the prospects of targeted inte...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2009.01.002

    authors： McCloskey MS,New AS,Siever LJ,Goodman M,Koenigsberg HW,Flory JD,Coccaro EF

    更新日期：2009-08-01 00:00:00

  • DRD3 and DAT1 genes in schizophrenia: an association study.

    abstract：OBJECTIVE:To investigate the role of the dopamine receptor 3 (DRD3) and transporter 1 (DAT1) genes in schizophrenia or in modulating its phenotype. METHODS:a Ser9Gly polymorphism in codon 9 of the DRD3 and a VNTR polymorphism in the DAT1genes were examined in two groups of schizophrenic patients, one of excellent neur...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/s0022-3956(00)00018-2

    authors： Joober R,Toulouse A,Benkelfat C,Lal S,Bloom D,Labelle A,Lalonde P,Turecki G,Rouleau GA

    更新日期：2000-07-01 00:00:00

  • Aldosterone concentrations in saliva reflect the duration and severity of depressive episode in a sex dependent manner.

    abstract：:Evidence is accumulating that aldosterone may exert central actions and influence mental functions. The aim of the present study was to test the hypothesis that major depressive disorder affects the diurnal variation of salivary aldosterone and that aldosterone concentrations reflect the duration and severity of the d...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2017.04.011

    authors： Segeda V,Izakova L,Hlavacova N,Bednarova A,Jezova D

    更新日期：2017-08-01 00:00:00

  • Triiodothyronine accelerates and enhances the antipsychotic effect of risperidone in acute schizophrenia.

    abstract：:In acute psychotic schizophrenia patients we investigated if the combination of triiodothyronine (T3) plus risperidone was more effective when compared to risperidone monotherapy. Thirty-two in-patients meeting the DSM-IV-TR diagnostic criteria for schizophrenia and without thyroid disease received risperidone (flexib...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.jpsychires.2015.11.007

    authors： Steibliene V,Bunevicius A,Savickas A,Prange AJ Jr,Nemeroff CB,Bunevicius R

    更新日期：2016-02-01 00:00:00

  • Perception of parent-child relationships in high-risk families, and adult schizophrenia outcome of offspring.

    abstract：:The current investigation examines perceived family relationships prior to the onset of psychopathology in a sample at high-risk for schizophrenia. Previous research suggests that environmental factors, such as family relationships, may contribute to later schizophrenia in high-risk individuals. This investigation ext...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/s0022-3956(01)00046-2

    authors： Schiffman J,LaBrie J,Carter J,Cannon T,Schulsinger F,Parnas J,Mednick S

    更新日期：2002-01-01 00:00:00

  • An electrocortical investigation of emotional face processing in military-related posttraumatic stress disorder.

    abstract：:PTSD is a disorder of emotion dysregulation. Although much work has intended to elucidate the neural underpinnings of the disorder, much remains unknown about the neurobiological substrates of emotion dysregulation in PTSD. In order to assess the relationship between a neural measure of attention to emotion (i.e. the ...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jpsychires.2017.03.013

    authors： DiGangi JA,Burkhouse KL,Aase DM,Babione JM,Schroth C,Kennedy AE,Greenstein JE,Proescher E,Phan KL

    更新日期：2017-09-01 00:00:00

  • Relation between cerebrospinal fluid, gray matter and white matter changes in families with schizophrenia.

    abstract：BACKGROUND:Gray matter reduction and ventricular enlargement belong to the best replicated findings in schizophrenia. Brain morphologic changes were also found in non-schizophrenic family members (FM). The intention of this study was to examine whether non-psychotic first-degree relatives reveal similar morphologic cha...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2005.04.009

    authors： Schneider-Axmann T,Kamer T,Moroni M,Maric N,Tepest R,Dani I,Honer WG,Scherk H,Rietschel M,Schulze TG,Müller DJ,Cordes J,Schönell H,Steinmetz H,Gaebel W,Vogeley K,Kühn KU,Wagner M,Maier W,Träber F,Block W,Schild

    更新日期：2006-10-01 00:00:00

  • From phone use to speeding and driving under influence: Identifying clusters of driving risk behaviors as an opportunity for targeted interventions.

    abstract：:Identifying the profile of risky behaviors among drivers is central to propose effective interventions. Due to the multidimensional and overlapping aspects of risky driving behaviors, cluster analysis can provide additional insights in order to identify specific subgroups of risk. This study aimed to identify clusters...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2020.11.025

    authors： Rabelo-da-Ponte FD,Scherer JN,Roglio V,Borges EN,Galland F,Sousa T,Passos IC,von Diemen L,Kessler F,Pechansky F

    更新日期：2020-11-12 00:00:00

  • Preliminary efficacy and tolerability profiles of first versus second-generation Long-Acting Injectable Antipsychotics in schizophrenia: A systematic review and meta-analysis.

    abstract：:We performed a systematic review and meta-analysis of the efficacy and safety of second generation (SG) long-acting antipsychotics (LAIAs) versus first generation (FG) LAIAs in schizophrenia. We conducted a comprehensive search in PubMed, MEDLINE, EMBASE and PsycINFO until May 2019. Inclusion criteria for randomized t...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章,评审

    doi：10.1016/j.jpsychires.2020.06.013

    authors： Saucedo Uribe E,Carranza Navarro F,Guerrero Medrano AF,García Cervantes KI,Álvarez Villalobos NA,Acuña Rocha VD,Méndez Hernández M,Millán Alanís JM,Hinojosa Cavada CM,Zúñiga Hernández JA,Fernández Zambrano SM

    更新日期：2020-10-01 00:00:00

  • Microglia mediated neuroinflammation in autism spectrum disorder.

    abstract：BACKGROUND:Although the precise pathophysiologies underlying autism spectrum disorder (ASD) has not yet been fully clarified, growing evidence supports the involvement of neuroinflammation in the pathogenesis of this disorder, with microglia being particular relevance in the pathophysiologic processes. OBJECTIVE:The p...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章,评审

    doi：10.1016/j.jpsychires.2020.07.013

    authors： Liao X,Yang J,Wang H,Li Y

    更新日期：2020-11-01 00:00:00

  • CT scans in sub-groups of chronic schizophrenics.

    abstract：:Measurements of the ventricular brain ratio (VBR), width of the sylvian fissure, and symmetry of the frontal lobes were obtained from 26 chronic schizophrenic patients, 22 alcoholic and neurological patients, and 20 normal controls. All schizophrenic subjects were non-responsive to long-term neuroleptic medication for...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/0022-3956(82)90042-5

    authors： Kling AS,Kurtz N,Tachiki K,Orzeck A

    更新日期：1982-01-01 00:00:00

  • Escitalopram but not placebo modulates brain rhythmic oscillatory activity in the first week of treatment of Major Depressive Disorder.

    abstract：:Serotonin modulates brain oscillatory activity, and serotonergic projections to the thalamus and cortex modulate the frequency of prefrontal rhythmic oscillations. Changes in serotonergic tone have been reported to shift oscillations between the combined delta-theta (2.5-8 Hz) and the alpha (8-12 Hz) frequency ranges....

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.jpsychires.2016.10.002

    authors： Leuchter AF,Hunter AM,Jain FA,Tartter M,Crump C,Cook IA

    更新日期：2017-01-01 00:00:00

  • Working memory dysfunction in obsessive-compulsive disorder: a neuropsychological and functional MRI study.

    abstract：:Previous neuropsychological studies indicate that OCD subtypes such as checking rituals might be associated with a working memory deficit. On the other hand, functional neuroimaging studies found functional abnormalities of the frontal cortex and subcortical structures in OCD. Combined with functional imaging method, ...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2008.10.013

    authors： Nakao T,Nakagawa A,Nakatani E,Nabeyama M,Sanematsu H,Yoshiura T,Togao O,Tomita M,Masuda Y,Yoshioka K,Kuroki T,Kanba S

    更新日期：2009-05-01 00:00:00

  • Migraine, physical health and psychiatric disorder: a prospective epidemiologic study in young adults.

    abstract：:In a prospective study of a random sample of 1,007 young adults, we examined the association between migraine and psychiatric disorder, physical complaints, indicators of functional impairment, and use of mental health services. A history of migraine was associated with increased lifetime rates of major depression, an...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/0022-3956(93)90009-q

    authors： Breslau N,Davis GC

    更新日期：1993-04-01 00:00:00

  • Self-harm behavior among individuals with intermittent explosive disorder and personality disorders.

    abstract：:Self-harm behaviors are a major public health concern across the lifespan, particularly among individuals with psychiatric disorders. Little research, however, has examined these behaviors among individuals with a diagnosis characterized by recurrent acts of impulsive aggression, Intermittent Explosive Disorder (IED)....

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2014.08.013

    authors： Jenkins AL,McCloskey MS,Kulper D,Berman ME,Coccaro EF

    更新日期：2015-01-01 00:00:00

  • Vitamin A supplementation at clinical doses induces a dysfunction in the redox and bioenergetics states, but did change neither caspases activities nor TNF-alpha levels in the frontal cortex of adult Wistar rats.

    abstract：:Vitamin A and its derivatives, the retinoids, exert modulatory roles on central nervous system (CNS) function. However, the clinical use of vitamin A at moderate to high doses induces serious side effects, including dysfunctional brain metabolism and mood disorders. Then, we have investigated in this work the effects ...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2008.10.002

    authors： De Oliveira MR,Oliveira MW,Behr GA,Moreira JC

    更新日期：2009-05-01 00:00:00

  • Treatment of a major depression episode suppresses markers of bone turnover in premenopausal women.

    abstract：UNLABELLED:Both decrease in bone mineral density and increase in bone turnover had been reported in patients with major depression compared to healthy controls. But the effect of antidepressant treatment on markers of bone turnover is not studied. The aim of this study was to investigate the effect of treatment of a ma...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2011.04.005

    authors： Aydin H,Mutlu N,Akbas NB

    更新日期：2011-10-01 00:00:00