当前位置： SCI文献检索 > JOURNAL OF PSYCHIATRIC RESEARCH期刊下所有文献 > Effects of doxycycline on depressive-like behavior in mice after lipopolysaccharide (LPS) administration.

Effects of doxycycline on depressive-like behavior in mice after lipopolysaccharide (LPS) administration.

Abstract：

:Current evidences support inflammation, oxidative and nitrogen stress, as well as brain-derived neurotrophic factor (BDNF) signaling mechanisms as important in depression pathophysiology. Tetracycline antibiotics have anti-inflammatory and antioxidant properties. Preliminary evidence indicates that minocycline has antidepressant properties. Doxycycline (DOXY) has favorable pharmacokinetic and safety profiles when compared to other tetracycline congeners. The antidepressant activity of DOXY has not been adequately investigated. This study evaluated the effects of DOXY (25 and 50 mg/kg, i.p.) on LPS-induced (0.5 mg/kg, i.p.) depressive-like behavior. Doxycycline was administered 30 min before LPS (pre-LPS) or 1.5 and 23.5 h following LPS (post-LPS) administration in mice. LPS-treated animals presented an increase in immobility time in the forced swimming test (FST) when compared to controls 24 h after endotoxin administration. Similarly to imipramine (IMI-10 mg/kg, i.p.), DOXY at both doses prevented and reversed LPS-induced alterations in the FST. IL-1β content was increased 24 h after LPS administration in striatum, hippocampus and prefrontal cortex. IMI and DOXY prevented and reversed LPS-induced increase in IL-1β. IMI and DOXY also prevented and reversed LPS-induced alterations in nitrite content and oxidative stress parameters (lipid peroxidation and reduced glutathione levels). Both DOXY and IMI prevented LPS-induced decrease in hippocampal BDNF levels. Taken together, our results demonstrate that DOXY is comparable to IMI in effectively ameliorate LPS-induced depressive-like behavior, providing a rationale for testing DOXY's antidepressant efficacy in humans.

journal_name

J Psychiatr Res

journal_title

Journal of psychiatric research

authors

Mello BS,Monte AS,McIntyre RS,Soczynska JK,Custódio CS,Cordeiro RC,Chaves JH,Vasconcelos SM,Nobre HV Jr,Florenço de Sousa FC,Hyphantis TN,Carvalho AF,Macêdo DS

doi

10.1016/j.jpsychires.2013.06.008

subject

Has Abstract

pub_date

2013-10-01 00:00:00

pages

1521-9

issue

10

eissn

0022-3956

issn

1879-1379

pii

S0022-3956(13)00191-X

journal_volume

47

pub_type

杂志文章,随机对照试验

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