当前位置： SCI文献检索 > JOURNAL OF PSYCHIATRIC RESEARCH期刊下所有文献 > Cingulate gyrus volumetry in drug free bipolar patients and patients treated with valproate or valproate and quetiapine.

Cingulate gyrus volumetry in drug free bipolar patients and patients treated with valproate or valproate and quetiapine.

Abstract：

:In patients with bipolar disorder, recent brain imaging studies have reported cingulate cortex volume change. We performed a volumetric magnetic resonance imaging (MRI) study to assess the subregions of the cingulate gyrus; left anterior cingulate (LAC), left posterior cingulate (LPC), right anterior cingulate (RAC), and right posterior cingulate (RPC). Our sample consisted of bipolar patients that are either unmedicated (n=10), on valproate monotherapy (n=10) or on valproate plus quetiapine (n=10) versus healthy comparisons (n=10). Thirty right-handed bipolar disordered patients were recruited. Of them, 10 were first-applying patients who never had taken any drug for this condition (medication-naive group), 10 were on valproate treatment (valproate group) and 10 were on valproate plus quetiapine treatment (valproate plus quetiapine group). Cingulate gyrus volumes included both cortex and white matter. Drug-free patients had significantly smaller LAC and LPC volumes compared with valproate and valproate plus quetiapine groups and healthy controls. In addition, in post hoc comparisons, a trend toward significant difference was found between valproate plus quetiapine group and valproate group in regard to only LAC. Our findings suggest that valproate and quetiapine may have neuroprotective effects.

journal_name

J Psychiatr Res

journal_title

Journal of psychiatric research

authors

Atmaca M,Ozdemir H,Cetinkaya S,Parmaksiz S,Belli H,Poyraz AK,Tezcan E,Ogur E

doi

10.1016/j.jpsychires.2006.07.006

subject

Has Abstract

pub_date

2007-11-01 00:00:00

pages

821-7

issue

10

eissn

0022-3956

issn

1879-1379

pii

S0022-3956(06)00142-7

journal_volume

41

pub_type

杂志文章

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