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The cerebellum in mild cognitive impairment and Alzheimer's disease - a structural MRI study.

Abstract：

:Neuropathological research consistently revealed the cerebellum to undergo degenerative changes in Alzheimer's disease (AD). Whether these alterations affect cerebellar morphology in vivo has not yet been investigated in a comprehensive way. Magnetic resonance imaging was performed in 20 patients with AD, 20 with mild cognitive impairment (MCI), and 20 healthy controls. By manual tracing the cerebellum was divided in four substructures (anterior lobe, superior posterior lobe, inferior posterior lobe and corpus medullare, respectively) on each hemisphere. Posterior cerebellar lobes were significantly smaller in AD patients when compared to healthy controls. In the AD group, atrophy of the posterior cerebellar regions was associated with poorer cognitive performance. Our findings lend further support for cerebellar involvement in AD.

journal_name

J Psychiatr Res

journal_title

Journal of psychiatric research

authors

Thomann PA,Schläfer C,Seidl U,Santos VD,Essig M,Schröder J

doi

10.1016/j.jpsychires.2007.12.002

subject

Has Abstract

pub_date

2008-10-01 00:00:00

pages

1198-202

issue

14

eissn

0022-3956

issn

1879-1379

pii

S0022-3956(07)00208-7

journal_volume

42

pub_type

杂志文章

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