当前位置： SCI文献检索 > JOURNAL OF PSYCHIATRIC RESEARCH期刊下所有文献 > Serum brain-derived neurotrophic factor levels in patients with major depression: effects of antidepressants.

Serum brain-derived neurotrophic factor levels in patients with major depression: effects of antidepressants.

Abstract：

:This study tried to investigate the relationships between serum brain-derived neurotrophic factor (BDNF) protein levels and major depressive patients and discuss the effects of antidepressants on the serum BDNF protein levels. A total of 218 participants, including 111 patients with major depression (91 women) and 107 healthy controls (65 women), were recruited in this study. Serum BDNF protein levels were measured using an ELISA kit. Psychiatric diagnoses were made according to DSM-IV criteria. Severity of major depression was assessed by the 17-item Hamilton Depression Rating Scale. Using analysis of covariance with age adjustment, there were significantly low serum BDNF protein levels in depressive patients than healthy controls in women (F=7.530, p=0.007), but not in men. Additionally, changes in serum BDNF protein levels were significantly increased in 79 patients taking antidepressants during a period of 4 weeks (t=2.116, p=0.038), especially in 61 women (t=2.542, p=0.014). Age-adjusted ANCOVA revealed no significant differences in serum BDNF protein levels between 58 responders and 21 non-responders (F=0.008, P=0.928). In responders, there were significantly increased changes in serum BDNF protein levels in 44 women (t=2.501, p=0.016), but not in 14 men (t=-0.767, p=0.457). These analytical results suggest that low serum BDNF may play an important role in depressive women and antidepressant treatment significantly increase serum BDNF. However, further studies of larger populations are necessary to confirm these results and further elucidate the effects of different classes of antidepressants on serum BDNF protein levels.

journal_name

J Psychiatr Res

journal_title

Journal of psychiatric research

authors

Huang TL,Lee CT,Liu YL

doi

10.1016/j.jpsychires.2007.05.007

subject

Has Abstract

pub_date

2008-06-01 00:00:00

pages

521-5

issue

7

eissn

0022-3956

issn

1879-1379

pii

S0022-3956(07)00091-X

journal_volume

42

pub_type

杂志文章

相关文献

JOURNAL OF PSYCHIATRIC RESEARCH文献大全
  • Factor structure of the Postpartum Bonding Questionnaire: Configural invariance and measurement invariance across postpartum time periods.

    abstract：BACKGROUND:Despite the research and clinical significance of the Postpartum Bonding Questionnaire (PBQ), its psychometric properties have not been studied intensively. The goodness-of-fit of proposed factor models of the PBQ is poor. Configural and measurement invariance have never been reported. METHODS:As a secondar...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2020.11.017

    authors： Matsunaga A,Ohashi Y,Sakanashi K,Kitamura T

    更新日期：2020-11-09 00:00:00

  • Bipolar disorder moderates associations between linoleic acid and markers of inflammation.

    abstract：:Dietary polyunsaturated fatty acids (PUFA) and inflammatory proteins associate with immune activation and have been implicated in the pathophysiology of mood disorders. We have previously reported that individuals with bipolar disorder (BPD) have decreased PUFA intake, including eicosapentaenoic acid (EPA), docosahexa...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2016.10.021

    authors： Chang YW,Assari S,Prossin AR,Stertz L,McInnis MG,Evans SJ

    更新日期：2017-02-01 00:00:00

  • The cerebellum in mild cognitive impairment and Alzheimer's disease - a structural MRI study.

    abstract：:Neuropathological research consistently revealed the cerebellum to undergo degenerative changes in Alzheimer's disease (AD). Whether these alterations affect cerebellar morphology in vivo has not yet been investigated in a comprehensive way. Magnetic resonance imaging was performed in 20 patients with AD, 20 with mild...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2007.12.002

    authors： Thomann PA,Schläfer C,Seidl U,Santos VD,Essig M,Schröder J

    更新日期：2008-10-01 00:00:00

  • Habituation of the auditory evoked field component N100m in male patients with schizophrenia.

    abstract：:The auditory evoked field (AEF) component N100m represents the most prominent and stable peak of the AEF, and its alterations in patients with schizophrenia are an extensive topic of neuropsychiatric research. In our current study, the degree of N100m habituation was investigated in 20 male schizophrenics and 19 healt...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/s0022-3956(00)00007-8

    authors： Rosburg T,Kreitschmann-Andermahr I,Nowak H,Sauer H

    更新日期：2000-05-01 00:00:00

  • Structural and functional brain alterations in psychiatric patients with dissociative experiences: A systematic review of magnetic resonance imaging studies.

    abstract：INTRODUCTION:There is currently no general agreement on how to best conceptualize dissociative symptoms and whether they share similar neural underpinnings across dissociative disorders. Neuroimaging data could help elucidate these questions. OBJECTIVES:The objective of this review is to summarize empirical evidence f...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章,评审

    doi：10.1016/j.jpsychires.2020.05.006

    authors： Lotfinia S,Soorgi Z,Mertens Y,Daniels J

    更新日期：2020-09-01 00:00:00

  • Folate, homocysteine, interleukin-6, and tumor necrosis factor alfa levels, but not the methylenetetrahydrofolate reductase C677T polymorphism, are risk factors for schizophrenia.

    abstract：:The methylenetetrahydrofolate reductase (MTHFR) C677T mutation has been associated to high homocysteine levels and schizophrenia. Since cytokines are altered in schizophrenia and increments of homocysteine could promote an inflammatory response, it was investigated whether interleukin-6 (IL-6) and tumor necrosis facto...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2009.10.011

    authors： García-Miss Mdel R,Pérez-Mutul J,López-Canul B,Solís-Rodríguez F,Puga-Machado L,Oxté-Cabrera A,Gurubel-Maldonado J,Arankowsky-Sandoval G

    更新日期：2010-05-01 00:00:00

  • Prospective study of chronotype and incident depression among middle- and older-aged women in the Nurses' Health Study II.

    abstract：BACKGROUND:Prior cross-sectional studies have suggested that being a late chronotype is associated with depression and depressive symptoms, but prospective data are lacking. METHODS:We examined the association between chronotype and incident depression (defined as self-reported physician/clinician-diagnosed depression...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2018.05.022

    authors： Vetter C,Chang SC,Devore EE,Rohrer F,Okereke OI,Schernhammer ES

    更新日期：2018-08-01 00:00:00

  • Major depression model induced by repeated and intermittent lipopolysaccharide administration: Long-lasting behavioral, neuroimmune and neuroprogressive alterations.

    abstract：:Major depressed patients show increased bacterial translocation with elevated plasma levels of lipopolysaccharide (LPS), which may trigger immune-inflammatory and neuro-oxidative responses. Recently, an animal model based on chronic LPS administration was developed which was associated with long-lasting depressive-lik...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2018.10.003

    authors： Rodrigues FTS,de Souza MRM,Lima CNC,da Silva FER,Costa DVDS,Dos Santos CC,Miyajima F,de Sousa FCF,Vasconcelos SMM,Barichello T,Quevedo J,Maes M,de Lucena DF,Macedo D

    更新日期：2018-12-01 00:00:00

  • Imipramine treatment of panic disorder with agoraphobia: the second time around.

    abstract：:The purpose of the present study was to assess and compare the therapeutic effects of imipramine during the initial treatment and retreatment of panic disorder with agoraphobia patients. Seven women with panic disorder with agoraphobia who had shown a marked and stable response to imipramine (121.4 +/- 41.8 mg/day) du...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/0022-3956(93)90050-c

    authors： Mavissakalian MR,Perel JM,de Groot C

    更新日期：1993-01-01 00:00:00

  • Neuroendocrine effects of benzodiazepines.

    abstract：:Benzodiazepine administration has been associated with alterations in neuroendocrine function both in experimental animals and in humans. Clinical and laboratory data indicate that the beta-carbolines, a class of active benzodiazepine receptor inverse agonists, cause behavioral and neuroendocrine changes characteristi...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章,评审

    doi：10.1016/0022-3956(90)90042-o

    authors： De Souza EB

    更新日期：1990-01-01 00:00:00

  • The familial transmission of primary major depressive disorder.

    abstract：:This is a study of the familial transmission of Primary Major Depressive Disorder in the families of 235 probands with this disorder ascertained as part of the NIMH-CRB Collaborative Depression Program. Eight hundred and twenty-six interviewed first degree relatives and 109 spouses are included. Research Diagnostic Cr...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/0022-3956(87)90112-9

    authors： Reich T,Van Eerdewegh P,Rice J,Mullaney J,Endicott J,Klerman GL

    更新日期：1987-01-01 00:00:00

  • Amygdalar expression of proteins associated with neuroplasticity in major depression and suicide.

    abstract：INTRODUCTION:Doublecortin (DCX) and polysialilated neural cell adhesion molecule (PSA-NCAM), two proteins associated with immature neuronal phenotypes and elevated neuroplasticity in the adult brain, have recently been identified in the mammalian amygdala, and evidence from rodent studies suggests that stress may modif...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2012.11.013

    authors： Maheu ME,Davoli MA,Turecki G,Mechawar N

    更新日期：2013-03-01 00:00:00

  • Platelet alpha 2-adrenoceptors in major depression: relationship with urinary 4-hydroxy-3-methoxyphenylglycol and age at onset.

    abstract：:Platelet alpha 2-adrenoceptor number and affinity were measured in 31 drug-free patients with major depressive illness utilizing 3H-clonidine as ligand. A significant negative correlation was found between number of alpha 2-adrenoceptors, baseline urinary 4-hydroxy-3-methoxyphenylglycol (MHPG) excretion, present age a...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/0022-3956(85)90077-9

    authors： Sacchetti E,Conte G,Pennati A,Vita A,Alciati A,Cazzullo CL

    更新日期：1985-01-01 00:00:00

  • Neuropsychological functions in anxiety disorders in population-based samples: evidence of episodic memory dysfunction.

    abstract：:Most of the available evidence on neuropsychological functioning in anxiety disorders is based on clinical samples, investigating persons affected by obsessive-compulsive disorder. Knowledge is sparse regarding cognitive functions in other types of anxiety disorders. The aim of this study was to examine whether person...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2004.06.001

    authors： Airaksinen E,Larsson M,Forsell Y

    更新日期：2005-03-01 00:00:00

  • Comorbidity of panic and major depressive disorder.

    abstract：:The objective of this report is to determine whether those patients with panic disorder who have current major depression disorder (MDD) differ from those who do not in terms of demographics, comorbid disorders, severity of illness, nature of symptoms of panic attacks and psychosocial functioning. The sample consisted...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章,多中心研究

    doi：10.1016/0022-3956(93)90015-t

    authors： Reich J,Warshaw M,Peterson LG,White K,Keller M,Lavori P,Yonkers KA

    更新日期：1993-01-01 00:00:00

  • Transcutaneous electrical acupoint stimulation as an adjunct therapy for obsessive-compulsive disorder: A randomized controlled study.

    abstract：BACKGROUND:Transcutaneous electrical acupoint stimulation (TEAS) is thought to have potential to treat obsessive-compulsive disorder (OCD). OBJECTIVE:The purpose of this study was to determine whether adding TEAS to cognitive behavioral therapy (CBT) and clomipramine would improve the efficacy of these conventional tr...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.jpsychires.2016.05.015

    authors： Feng B,Zhang ZJ,Zhu RM,Yuan GZ,Luo LY,McAlonan GM,Xu FZ,Chen J,Liu LY,Lv YY,Wong HK,Zhang Y,Zhu LX

    更新日期：2016-09-01 00:00:00

  • Using longitudinal prescription data to examine the incidence of other chronic diseases following antidepressant use.

    abstract：:Depression not only creates enormous costs for treatment and lost work time, but also increases the risk for other costly chronic diseases such as cardiovascular disease and diabetes. The magnitude of these risks remains unclear, with existing prospective studies using small sample sizes with limited diversity and rel...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2020.02.030

    authors： Teng A,Taylor Z,Pfeffer J,Williams LM

    更新日期：2020-06-01 00:00:00

  • Tolerability of the dexamethasone-corticotropin releasing hormone test in major depressive disorder.

    abstract：BACKGROUND:The dexamethasone-corticotropin releasing hormone (Dex-CRH) test may differentially predict which depressed patients will respond to antidepressant medication. However, a comprehensive analysis of the safety of this test in psychiatric patients has not previously been performed. METHODS:We conducted a poole...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2010.04.020

    authors： Dunlop BW,Betancourt Y,Binder EB,Heim C,Holsboer F,Ising M,McKenzie M,Mletzko T,Pfister H,Nemeroff CB,Craighead WE,Mayberg HS

    更新日期：2011-01-01 00:00:00

  • Occupational therapy in anorexia nervosa.

    abstract：:The use of activity which is carefully planned so as to facilitate change in the patient is a unique characteristic of occupational therapy. Occupational therapy closely resembles the actual living situation more so than any other treatment setting and therefore provides a realistic environment in which the patient ca...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/0022-3956(85)90054-8

    authors： Martin JE

    更新日期：1985-01-01 00:00:00

  • Perception of parent-child relationships in high-risk families, and adult schizophrenia outcome of offspring.

    abstract：:The current investigation examines perceived family relationships prior to the onset of psychopathology in a sample at high-risk for schizophrenia. Previous research suggests that environmental factors, such as family relationships, may contribute to later schizophrenia in high-risk individuals. This investigation ext...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/s0022-3956(01)00046-2

    authors： Schiffman J,LaBrie J,Carter J,Cannon T,Schulsinger F,Parnas J,Mednick S

    更新日期：2002-01-01 00:00:00

  • Different serine and glycine metabolism in patients with schizophrenia receiving clozapine.

    abstract：:Dysfunction of the N-methyl-d-aspartate receptor, which is modulated by excitatory amino acids (EAA), is involved in the pathophysiology of schizophrenia. The effects of antipsychotics on EAA metabolism are uncertain. Positive clinical effects of treatment with antipsychotics were not always associated with changes in...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2012.03.015

    authors： Hons J,Vasatova M,Cermakova E,Doubek P,Libiger J

    更新日期：2012-06-01 00:00:00

  • Gender differences in platelet brain derived neurotrophic factor in patients with cardiovascular disease and depression.

    abstract：:Women have a higher prevalence of depression compared to men. Serum levels of Brain-derived neurotrophic factor (BDNF) are decreased in depression. BDNF may also have a protective role in the pathogenesis of coronary artery disease (CAD) or events. We examined whether there are gender differences in BDNF levels in pat...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2016.03.013

    authors： Williams MS,Ngongang CK,Ouyang P,Betoudji F,Harrer C,Wang NY,Ziegelstein RC

    更新日期：2016-07-01 00:00:00

  • The potential role of atypical antipsychotics for the treatment of posttraumatic stress disorder.

    abstract：:Despite the fact that the majority of currently available treatment guidelines propose antidepressants as the first-line pharmacological therapy for posttraumatic stress disorder (PTSD), a substantial portion of patients fail to show an adequate response following this type of treatment. In this context, a number of s...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.jpsychires.2014.05.003

    authors： Han C,Pae CU,Wang SM,Lee SJ,Patkar AA,Masand PS,Serretti A

    更新日期：2014-09-01 00:00:00

  • Depressive comorbidity of panic, social phobic, and obsessive-compulsive disorders re-examined: is there a bipolar II connection?

    abstract：:Utilizing the DSM-III-R schema, we have investigated lifetime comorbidity between panic disorder with or without agoraphobia (PD), social phobia (SP) and obsessive-compulsive disorder (OCD) on the one hand, and mood disorder on the other. Compared with PD, the results for SP and OCD showed significantly higher numbers...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/s0022-3956(98)00044-2

    authors： Perugi G,Akiskal HS,Ramacciotti S,Nassini S,Toni C,Milanfranchi A,Musetti L

    更新日期：1999-01-01 00:00:00

  • Peripheral biomarkers and illness activity in bipolar disorder.

    abstract：:Recent evidence suggests that peripheral markers related to oxidative stress, inflammation and neurotrophins may be altered during mood episodes in bipolar disorder. These can be seen as proxies of peripheral toxicity or markers of illness activity. Here we report an en bloc assessment of a set of previously described...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2010.05.015

    authors： Kapczinski F,Dal-Pizzol F,Teixeira AL,Magalhaes PV,Kauer-Sant'Anna M,Klamt F,Moreira JC,de Bittencourt Pasquali MA,Fries GR,Quevedo J,Gama CS,Post R

    更新日期：2011-02-01 00:00:00

  • Altered Rap1 endogenous phosphorylation and levels in platelets from patients with bipolar disorder.

    abstract：:Previous studies have reported abnormalities either in the cAMP-dependent endogenous phosphorylation or in the levels of Rap1 in platelets from bipolar patients. One limitation of these findings was that they come from different groups of patients in independent studies. To overcome this limitation, we designed the pr...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/s0022-3956(99)00047-3

    authors： Perez J,Tardito D,Mori S,Racagni G,Smeraldi E,Zanardi R

    更新日期：2000-03-01 00:00:00

  • Evidence for the role of the dorsal ventral lateral posterior thalamic nucleus connectivity in deep brain stimulation for Gilles de la Tourette syndrome.

    abstract：:Gilles de la Tourette syndrome (GTS) can manifest as debilitating, medically-refractory tics for which deep brain stimulation (DBS) of the centromedian-parafascicular complex (CM) can provide effective treatment. However, patients have reported benefit with activation of contacts dorsal to the CM and likely in the ven...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2020.09.024

    authors： Kakusa B,Saluja S,Barbosa DAN,Cartmell S,Espil FM,Williams NR,McNab JA,Halpern CH

    更新日期：2021-01-01 00:00:00

  • The 12-year trend report of antipsychotic usage in a nationwide claims database derived from four million people in Japan.

    abstract：:The current study aimed to describe the use of antipsychotics to clarify the gap between clinical guidelines and health care practice in Japan. We used data from the JMDC Claims Database (JMDC Inc., Tokyo, Japan), a nationwide claims database, from 2005 to 2016. Antipsychotics were defined as drugs coded as N05A with ...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2020.05.012

    authors： Hata T,Kanazawa T,Hamada T,Nishihara M,Yoneda H,Nakajima M,Katsumata T

    更新日期：2020-08-01 00:00:00

  • A comparison of the Cohen-Mansfield agitation inventory with the CERAD behavioral rating scale for dementia in community-dwelling persons with Alzheimer's disease.

    abstract：:In a group of 242 community-dwelling patients with Alzheimer's disease (AD), a longitudinal comparison was made of two caregiver-administered instruments for assessment of behavioral disturbance; the Cohen-Mansfield Agitation Inventory (CMAI) and the CERAD Behavioral Rating Scale for Dementia (BRSD). We examined recor...

    journal_title：Journal of psychiatric research

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0022-3956(98)00027-2

    authors： Weiner MF,Koss E,Patterson M,Jin S,Teri L,Thomas R,Thal LJ,Whitehouse P

    更新日期：1998-11-01 00:00:00

  • Revised diagnostic criteria and a new structured interview for diagnosing anxiety disorders.

    abstract：:In recent years there has been a growing interest in the diagnosis and treatment of Anxiety Disorders. A fundamental assumption of the newer treatments is the identification of specific subtypes of Anxiety Disorders. Although the DSM-III classification of Anxiety Disorders is widely accepted, research experience since...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/0022-3956(88)90069-6

    authors： Spitzer RL,Williams JB

    更新日期：1988-01-01 00:00:00