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Tolerability of the dexamethasone-corticotropin releasing hormone test in major depressive disorder.

Abstract：

BACKGROUND:The dexamethasone-corticotropin releasing hormone (Dex-CRH) test may differentially predict which depressed patients will respond to antidepressant medication. However, a comprehensive analysis of the safety of this test in psychiatric patients has not previously been performed. METHODS:We conducted a pooled analysis of depressed patients in four clinical studies. Observed and subjectively reported side-effects in 454 patients were collected for 90 minutes following CRH administration. Pre-test electrocardiograms were available in 250 patients to assess cardiac safety. Descriptive statistics were performed to evaluate these safety data. RESULTS:Eight-six (18.9%) subjects experienced no side-effects from the procedure. The mean number of side-effects per subject was 1.4±1.0. The most frequent adverse events were: flushing (n=216, 47.6%), feeling of warmth (144, 31.7%), hyperpnea/tachypnea (108, 23.8%), palpitations (37, 8.1%), and tachycardia (28, 6.2%). Side-effects were consistently mild and brief in duration. There were no serious adverse events. CONCLUSION:The Dex-CRH test produces a mild, predictable side-effect profile, characterized by flushing, feelings of warmth, hyperpnea/tachypnea, palpitations, and tachycardia. These results provide reassurance that the Dex-CRH test is well tolerated in psychiatric patients.

journal_name

J Psychiatr Res

journal_title

Journal of psychiatric research

authors

Dunlop BW,Betancourt Y,Binder EB,Heim C,Holsboer F,Ising M,McKenzie M,Mletzko T,Pfister H,Nemeroff CB,Craighead WE,Mayberg HS

doi

10.1016/j.jpsychires.2010.04.020

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

24-8

issue

1

eissn

0022-3956

issn

1879-1379

pii

S0022-3956(10)00130-5

journal_volume

45

pub_type

杂志文章

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