当前位置： SCI文献检索 > JOURNAL OF PSYCHIATRIC RESEARCH期刊下所有文献 > NT-proBNP is a potential mediator between reduced ejection fraction and depression in patients with heart failure.

NT-proBNP is a potential mediator between reduced ejection fraction and depression in patients with heart failure.

Abstract：

:Depression and anxiety are prevalent in patients with heart failure (HF). Reduced ejection fraction (EF) and increased N-terminal-prohormone B-type natriuretic peptide (NT-proBNP) have been shown to be independently associated with depressive symptoms and may therefore increase HF disease progression and mortality. This study evaluated whether NT-proBNP mediated the impact of reduced EF on depressive and anxiety symptoms in patients with HF. Participants (n = 124) were patients with a diagnosis of chronic HF enrolled in the Heart Failure Disease Management Program at Health Sciences North. Subjects were assessed for depressive and anxiety symptoms according to the Hospital Anxiety and Depression Scale questionnaire at enrolment. Ejection fraction, measured through Multigated Acquisition Technique and NT-proBNP, measured through chemiluminescent immunoassay, were obtained at baseline. Patient outcomes were monitored for 12-months after enrollment. Associations were determined using regression and multivariate models. Indirect effects were assessed using mediation analysis. EF and NT-proBNP were highly correlated. Mediation analysis showed no significant direct effect of EF on the levels of depressive and anxiety symptoms, however, there was a significant indirect effect of EF on depression that was mediated by the levels of NT-proBNP, but not for EF and anxiety. Our results suggest that NT-proBNP is a potential mechanism linking reduced EF and depressive symptoms in patients with HF. While results are still preliminary, this study suggests that NT-proBNP may be a potential biomarker in identifying HF patients with reduced EF at high risk for depression, disease progression and mortality.

journal_name

J Psychiatr Res

journal_title

Journal of psychiatric research

authors

Zuzarte P,Scola G,Duong A,Kostiw K,Figueira ML,Costa-Vitali A

doi

10.1016/j.jpsychires.2018.06.010

subject

Has Abstract

pub_date

2018-09-01 00:00:00

pages

8-15

eissn

0022-3956

issn

1879-1379

pii

S0022-3956(18)30077-3

journal_volume

104

pub_type

杂志文章

相关文献

JOURNAL OF PSYCHIATRIC RESEARCH文献大全
  • Serum brain-derived neurotrophic factor levels in patients with major depression: effects of antidepressants.

    abstract：:This study tried to investigate the relationships between serum brain-derived neurotrophic factor (BDNF) protein levels and major depressive patients and discuss the effects of antidepressants on the serum BDNF protein levels. A total of 218 participants, including 111 patients with major depression (91 women) and 107...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2007.05.007

    authors： Huang TL,Lee CT,Liu YL

    更新日期：2008-06-01 00:00:00

  • Schizophrenic performance on line bisection: no simple lateralization defects.

    abstract：:Many studies have assessed the possible lateralization deficits of schizophrenics, and the results usually suggest left hemisphere dysfunction. Nevertheless, they have been variable. This may have been due to cognitive demand of the different tasks, not to changes in brain lateralization itself. In order to circumvent...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/0022-3956(90)90058-x

    authors： Mather JA,Neufeld RW,Merskey H,Russell NC

    更新日期：1990-01-01 00:00:00

  • ABCB1 gene polymorphisms and violent suicide attempt among survivors.

    abstract：INTRODUCTION:Those suicide attempters that choose violent methods dramatically diminish the possibility of survival. Completed suicide using violent means, which is common among first-time suicide attempters, was recently found to be more likely among T allele carriers in the three most common ABCB1 SNPs, encoding for ...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2014.12.005

    authors： Peñas-Lledó E,Guillaume S,Delgado A,Naranjo ME,Jaussent I,LLerena A,Courtet P

    更新日期：2015-02-01 00:00:00

  • Hair cortisol concentrations and cortisol stress reactivity in generalized anxiety disorder, major depression and their comorbidity.

    abstract：:Studies investigating cortisol secretion in patients with generalized anxiety disorder (GAD) have reported heterogeneous findings. Further, current knowledge on the specificity of endocrine changes for GAD and/or comorbid major depression (MD) is limited. Hence, the current study investigated long-term integrated cort...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2016.09.024

    authors： Steudte-Schmiedgen S,Wichmann S,Stalder T,Hilbert K,Muehlhan M,Lueken U,Beesdo-Baum K

    更新日期：2017-01-01 00:00:00

  • A single DEX/CRH test in male drug-free depressed patients is associated with the clinical response to treatment with fluoxetine.

    abstract：OBJECTIVES:The DEX/CRH test has been proposed to be suitable as a biomarker for the prediction of treatment response in depression. METHODS:We performed the DEX/CRH test in 10 severely depressed male patients with melancholic features before initiation of antidepressant treatment with 20 mg fluoxetine. RESULTS:We fou...

    journal_title：Journal of psychiatric research

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.jpsychires.2010.04.010

    authors： Paslakis G,Heuser I,Schweiger U,Deuschle M

    更新日期：2010-12-01 00:00:00

  • Induced abortion and anxiety, mood, and substance abuse disorders: isolating the effects of abortion in the national comorbidity survey.

    abstract：:The purpose of this study was to examine associations between abortion history and a wide range of anxiety (panic disorder, panic attacks, PTSD, Agoraphobia), mood (bipolar disorder, mania, major depression), and substance abuse disorders (alcohol and drug abuse and dependence) using a nationally representative US sam...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2008.10.009

    authors： Coleman PK,Coyle CT,Shuping M,Rue VM

    更新日期：2009-05-01 00:00:00

  • An electrocortical investigation of emotional face processing in military-related posttraumatic stress disorder.

    abstract：:PTSD is a disorder of emotion dysregulation. Although much work has intended to elucidate the neural underpinnings of the disorder, much remains unknown about the neurobiological substrates of emotion dysregulation in PTSD. In order to assess the relationship between a neural measure of attention to emotion (i.e. the ...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jpsychires.2017.03.013

    authors： DiGangi JA,Burkhouse KL,Aase DM,Babione JM,Schroth C,Kennedy AE,Greenstein JE,Proescher E,Phan KL

    更新日期：2017-09-01 00:00:00

  • Efficacy and safety of TS-121, a novel vasopressin V1B receptor antagonist, as adjunctive treatment for patients with major depressive disorder: A randomized, double-blind, placebo-controlled study.

    abstract：:Vasopressin 1B (V1B) receptor has a pivotal role in the regulation of the hypothalamus-adrenal-pituitary axis, and V1B receptor antagonists have shown efficacy in a number of preclinical models of depression. The efficacy and safety of, TS-121 (active ingredient: THY1773), a novel V1B receptor antagonist, was investig...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2020.05.017

    authors： Kamiya M,Sabia HD,Marella J,Fava M,Nemeroff CB,Umeuchi H,Iijima M,Chaki S,Nishino I

    更新日期：2020-09-01 00:00:00

  • The role of estrogen and progesterone in depression after birth.

    abstract：:Previous reports suggest that massive hormonal changes that accompany the peripartum period may trigger perinatal depression. We investigated the relationship between magnitude of change and total level of estrogen and progesterone and grade of peripartal depression and depressive symptoms. One hundred and ninety two ...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2006.09.002

    authors： Klier CM,Muzik M,Dervic K,Mossaheb N,Benesch T,Ulm B,Zeller M

    更新日期：2007-04-01 00:00:00

  • A twin study of amino acid concentrations in cerebrospinal fluid.

    abstract：:The concentrations of amino acids in the cerebrospinal fluid (CSF) were measured in pairs of healthy mono- and dizygotic twins. Intraclass correlations were calculated. Genetic and cultural heritabilities were estimated using a path analytical model. CSF levels of glycine, tyrosine and arginine were shown to be influe...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/0022-3956(88)90028-3

    authors： Hagenfeldt L,Oxenstierna G,Alfredsson G,Edman G,Iselius L,Sedvall G

    更新日期：1988-01-01 00:00:00

  • Affective disorders and ABO blood groups: new data and a reanalysis of the literature using the logistic transformation of proportions.

    abstract：:No statistically significant associations were found between ABO blood group distributions and RDC subtype diagnoses in 79 subjects with unipolar (single episode and recurrent) and bipolar major depressive disorder using data from our sample. We discuss methodological issues related to the control samples and choice o...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/0022-3956(84)90003-7

    authors： Lavori PW,Keller MB,Roth SL

    更新日期：1984-01-01 00:00:00

  • The effect of elevated systemic cortisol levels on plasma catecholamines in Cushing's syndrome patients with and without depressed mood.

    abstract：:This study explored the effect of elevated systemic cortisol levels on plasma epinephrine and norepinephrine, and hemodynamic variables, in patients with active Cushing's syndrome; ratings of depressed mood were also obtained. Norepinephrine levels were significantly negatively correlated with 24 h urinary free cortis...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/0022-3956(95)00017-y

    authors： Cameron OG,Starkman MN,Schteingart DE

    更新日期：1995-09-01 00:00:00

  • Investigation of the expression of genes affecting cytomatrix active zone function in the amygdala in schizophrenia: effects of antipsychotic drugs.

    abstract：:The cytomatrix active zone (CAZ) is a specialized cellular structure regulating release of vesicles. We reported previously increased expression of three CAZ genes, piccolo, RIMS2 and RIMS3 in the amygdala in schizophrenia. This study determined the levels of gene and protein expression for components of the active zo...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2008.04.001

    authors： Weidenhofer J,Scott RJ,Tooney PA

    更新日期：2009-01-01 00:00:00

  • Cingulate gyrus volumetry in drug free bipolar patients and patients treated with valproate or valproate and quetiapine.

    abstract：:In patients with bipolar disorder, recent brain imaging studies have reported cingulate cortex volume change. We performed a volumetric magnetic resonance imaging (MRI) study to assess the subregions of the cingulate gyrus; left anterior cingulate (LAC), left posterior cingulate (LPC), right anterior cingulate (RAC), ...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2006.07.006

    authors： Atmaca M,Ozdemir H,Cetinkaya S,Parmaksiz S,Belli H,Poyraz AK,Tezcan E,Ogur E

    更新日期：2007-11-01 00:00:00

  • Serum concentrations of brain-derived neurotrophic factor in patients with gender identity disorder.

    abstract：:Gender Identity Disorder (GID) is characterized by a strong and persistent cross-gender identification that affects different aspects of behavior. Brain-derived neurotrophic factor (BDNF) plays a critical role in neurodevelopment and neuroplasticity. Altered BDNF-signaling is thought to contribute to the pathogenesis ...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2013.04.012

    authors： Fontanari AM,Andreazza T,Costa ÂB,Salvador J,Koff WJ,Aguiar B,Ferrari P,Massuda R,Pedrini M,Silveira E,Belmonte-de-Abreu PS,Gama CS,Kauer-Sant'Anna M,Kapczinski F,Lobato MI

    更新日期：2013-10-01 00:00:00

  • Perceived stress influences anhedonia and social functioning in a community sample enriched for psychosis-risk.

    abstract：:Existing animal and human research support the causal role of stress in the emergence of anhedonia, and in turn, the influence of anhedonia in social functioning. However, this model has not been tested in relation to psychosis-risk; this literature gap is notable given that both anhedonia and declining social functio...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2021.01.005

    authors： Pelletier-Baldelli A,Strauss GP,Kuhney FS,Chun C,Gupta T,Ellman LM,Schiffman J,Mittal VA

    更新日期：2021-01-11 00:00:00

  • Computational non-linear dynamical psychiatry: a new methodological paradigm for diagnosis and course of illness.

    abstract：:The goal of this article is to highlight the significant potential benefits of applying computational mathematical models to the field of psychiatry, specifically in relation to diagnostic conceptualization. The purpose of these models is to augment the current diagnostic categories that utilize a "snapshot" approach ...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章,评审

    doi：10.1016/j.jpsychires.2011.10.013

    authors： Bystritsky A,Nierenberg AA,Feusner JD,Rabinovich M

    更新日期：2012-04-01 00:00:00

  • Association between psychological morbidities and information provision, reliability, and satisfaction among disaster victims: A cross-sectional study.

    abstract：:Providing information about disaster relief services and recovery processes reduces the damage from disasters and enables disaster victims to respond to disasters effectively. The present study aimed to clarify the associations between provision, reliability, satisfaction of information and satisfaction with media cov...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2020.08.010

    authors： Kang E

    更新日期：2020-11-01 00:00:00

  • Neuropsychological profile in patients with obsessive-compulsive disorder over a period of 4-month treatment.

    abstract：:This study investigated the changes of the neuropsychological functions over a 4-month period of treatment in patients with obsessive-compulsive disorder (OCD). Thirty-nine OCD patients and 31 healthy controls were evaluated with neuropsychological and clinical tests. The same tests were readministered 4-months after ...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/s0022-3956(02)00017-1

    authors： Kim MS,Park SJ,Shin MS,Kwon JS

    更新日期：2002-07-01 00:00:00

  • An exploratory study of salivary cortisol changes during chamomile extract therapy of moderate to severe generalized anxiety disorder.

    abstract：OBJECTIVES:Dysfunctions in stress biology are hypothesized to contribute to anxiety disorders, and to be ameliorated during successful treatment, but limited clinical data exist to support this hypothesis. We evaluated whether increases in morning cortisol and the diurnal cortisol slope, markers of stress biology, are ...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.jpsychires.2017.10.011

    authors： Keefe JR,Guo W,Li QS,Amsterdam JD,Mao JJ

    更新日期：2018-01-01 00:00:00

  • Comparison of generic and disease-specific measures of quality of life in first-episode psychosis.

    abstract：BACKGROUND:Quality of life (QOL) is now recognised as an important measure of outcome that could potentially influence clinical decision-making for those with a first-episode psychosis (FEP). A number of QOL instruments are available however; many differ in their conceptual orientation which may have serious implicatio...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2013.06.001

    authors： Renwick L,Lyne J,Owens E,O' Donoghue B,Madigan K,Turner N,Drennan J,Sheridan A,Kinsella A,Clarke M,O' Callaghan E

    更新日期：2013-10-01 00:00:00

  • Maternal choline and respiratory coronavirus effects on fetal brain development.

    abstract：:Prenatal COVID-19 infection is anticipated by the U.S. Centers for Disease Control to affect fetal development similarly to other common respiratory coronaviruses through effects of the maternal inflammatory response on the fetus and placenta. Plasma choline levels were measured at 16 weeks gestation in 43 mothers who...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2020.05.019

    authors： Freedman R,Hunter SK,Law AJ,D'Alessandro A,Noonan K,Wyrwa A,Camille Hoffman M

    更新日期：2020-09-01 00:00:00

  • A summary of attentional findings in the New York High-Risk Project.

    abstract：:We summarize here our findings with respect to attentional impairment among offspring of schizophrenic, affectively ill, and normal parents followed from childhood to adulthood during the two decades of the New York High-Risk Project (NYHRP). We review our data first, on childhood attentional performance in each of ou...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/0022-3956(92)90043-n

    authors： Erlenmeyer-Kimling L,Cornblatt BA

    更新日期：1992-10-01 00:00:00

  • Epidemiology of depression and its treatment in the general population.

    abstract：:This study examines the correlates of a major depressive disorder and its treatment in the general population. The sample was composed of 6694 individuals aged between 18 and 96 years, representative of the general population of the states of California and New York (48 million inhabitants aged 18 years or older). The...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2006.10.006

    authors： Ohayon MM

    更新日期：2007-04-01 00:00:00

  • Circadian periodicity, adrenal corticosteroids, and the EEG of normal man.

    abstract：:Human EEG activity in the conventional frequency range of 1-30 c/s is a well-established entity. This paper illustrates a method for utilizing a conventional EEG frequency analyser to demonstrate a considerably lower frequency, circadian (about 24-h) rhythm in the EEGs of a group of human volunteers. This periodicity ...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/0022-3956(66)90020-3

    authors： Frank G,Halberg F,Harner R,Matthews J,Johnson E,Gravem H,Andrus V

    更新日期：1966-11-01 00:00:00

  • Perception of parent-child relationships in high-risk families, and adult schizophrenia outcome of offspring.

    abstract：:The current investigation examines perceived family relationships prior to the onset of psychopathology in a sample at high-risk for schizophrenia. Previous research suggests that environmental factors, such as family relationships, may contribute to later schizophrenia in high-risk individuals. This investigation ext...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/s0022-3956(01)00046-2

    authors： Schiffman J,LaBrie J,Carter J,Cannon T,Schulsinger F,Parnas J,Mednick S

    更新日期：2002-01-01 00:00:00

  • Affective reactivity of speech disturbances in schizotypy.

    abstract：:Speech disturbances (SD) are a pernicious symptom of schizophrenia that increase when negative emotion is elicited. This increase is referred to as affective reactivity (AR). Although considerable research has examined SD in schizophrenia, few studies have investigated this symptom in individuals at risk for the disor...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2009.06.005

    authors： Minor KS,Cohen AS

    更新日期：2010-01-01 00:00:00

  • Inverted face processing in body dysmorphic disorder.

    abstract：:Individuals with body dysmorphic disorder (BDD) are preoccupied with perceived defects in appearance. Preliminary evidence suggests abnormalities in global and local visual information processing. The objective of this study was to compare global and local processing in BDD subjects and healthy controls by testing the...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2010.03.015

    authors： Feusner JD,Moller H,Altstein L,Sugar C,Bookheimer S,Yoon J,Hembacher E

    更新日期：2010-11-01 00:00:00

  • Satiety responses in eating disorders.

    abstract：:Appetite and satiety responses in a test meal paradigm were studied in six anorexia nervosa patients (four had bingeing and purging behaviors) and in nine normal control women. The anorexic patients were distinguished from normal controls by the amounts of food taken and by the pattern of the hunger and fullness respo...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/0022-3956(85)90029-9

    authors： Owen WP,Halmi KA,Gibbs J,Smith GP

    更新日期：1985-01-01 00:00:00

  • Decreased prefrontal, anterior cingulate, insula, and ventral striatal metabolism in medication-free depressed outpatients with bipolar disorder.

    abstract：:This study explored whether cerebral metabolic changes seen in treatment resistant and rapid cycling bipolar depression inpatients are also found in an outpatient sample not specifically selected for treatment resistance or rapid cycling. We assessed 15 depressed outpatients with bipolar disorder (six type I and nine ...

    journal_title：Journal of psychiatric research

    pub_type： 杂志文章

    doi：10.1016/j.jpsychires.2008.04.015

    authors： Brooks JO 3rd,Wang PW,Bonner JC,Rosen AC,Hoblyn JC,Hill SJ,Ketter TA

    更新日期：2009-01-01 00:00:00