Abstract:
:The goal of this article is to highlight the significant potential benefits of applying computational mathematical models to the field of psychiatry, specifically in relation to diagnostic conceptualization. The purpose of these models is to augment the current diagnostic categories that utilize a "snapshot" approach to describing mental states. We hope to convey to researchers and clinicians that non-linear dynamics can provide an additional useful longitudinal framework to understand mental illness. Psychiatric phenomena are complex processes that evolve in time, similar to many other processes in nature that have been successfully described and understood within deterministic chaos and non-linear dynamic computational models. Dynamical models describe mental processes and phenomena that change over time, more like a movie than a photograph, with multiple variables interacting over time. The use of these models may help us understand why and how current diagnostic categories are insufficient. They may also provide a new, more descriptive and ultimately more predictive approach leading to better understanding of the interrelationship between psychological, neurobiological, and genetic underpinnings of mental illness.
journal_name
J Psychiatr Resjournal_title
Journal of psychiatric researchauthors
Bystritsky A,Nierenberg AA,Feusner JD,Rabinovich Mdoi
10.1016/j.jpsychires.2011.10.013subject
Has Abstractpub_date
2012-04-01 00:00:00pages
428-35issue
4eissn
0022-3956issn
1879-1379pii
S0022-3956(11)00261-5journal_volume
46pub_type
杂志文章,评审abstract::Gender Identity Disorder (GID) is characterized by a strong and persistent cross-gender identification that affects different aspects of behavior. Brain-derived neurotrophic factor (BDNF) plays a critical role in neurodevelopment and neuroplasticity. Altered BDNF-signaling is thought to contribute to the pathogenesis ...
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pub_type: 杂志文章,多中心研究,随机对照试验
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