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Cortisol responses to combined dexamethasone/CRH test in outpatients with a major depressive episode.

Abstract：

:The DEX/CRH test is now a well established method to test the hypothalamic-pituitary-adrenal (HPA) axis for depressed patients in an inpatient setting. The aim of this study was to evaluate this test in an outpatient population suffering from major depression compared to a healthy control group. The main result is a statistically significant difference concerning the delta value for cortisol plasma value on the DEX/CRH test for depressed patients with two or more previous episodes compared to healthy controls. On the contrary, the difference was not statistically significant for patients with only one or no previous episodes. In future studies, it could be interesting to use this test more specifically by dividing ambulatory patients into subgroups according to their past depressive history. It could also be interesting to measure the ACTH level.

journal_name

J Psychiatr Res

journal_title

Journal of psychiatric research

authors

Gervasoni N,Bertschy G,Osiek C,Perret G,Denis R,Golaz J,Rossier MF,Bondolfi G,Aubry JM

doi

10.1016/j.jpsychires.2004.04.008

subject

Has Abstract

pub_date

2004-11-01 00:00:00

pages

553-7

issue

6

eissn

0022-3956

issn

1879-1379

pii

S0022395604000500

journal_volume

38

pub_type

临床试验,杂志文章

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