Abstract：
:Thirty-one elderly depressed patients were treated for seven weeks with nortriptyline with plasma levels kept between 50-180 ng/ml. Electrocardiograms were taken at the third and seventh weeks of treatment. There were significant increases in the PR interval, QTc interval, and heart rate from before and after treatment. However, there were no consistent correlations between electrocardiographic changes during treatment and plasma levels of nortriptyline, 10-hydroxynortriptyline and either of its two isomers (E-10-hydroxynortriptyline, Z-10-hydroxynortriptyline). Increased QRS duration after seven weeks of treatment was correlated with daily dose of nortriptyline.
journal_name
J Psychiatr Resjournal_title
Journal of psychiatric researchauthors
McCue RE,Georgotas A,Nagachandran N,Abdul Basir M,Go EA,Suckow RF,Cooper TBdoi
10.1016/0022-3956(89)90019-8subject
Has Abstractpub_date
1989-01-01 00:00:00pages
73-9issue
1eissn
0022-3956issn
1879-1379journal_volume
23pub_type
临床试验,杂志文章,随机对照试验abstract：:Body-focused repetitive behaviors (BFRBs) and non-suicidal self-injury (NSSI) are recognized as distinct categories in the DSM-5. However, definitions and assessment of NSSI sometimes encompasses behaviors similar to BFRBs, and little data exist about their clinical differences. The current study examined clinical cha...
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