Abstract：
OBJECTIVE:To investigate the role of the dopamine receptor 3 (DRD3) and transporter 1 (DAT1) genes in schizophrenia or in modulating its phenotype. METHODS:a Ser9Gly polymorphism in codon 9 of the DRD3 and a VNTR polymorphism in the DAT1genes were examined in two groups of schizophrenic patients, one of excellent neuroleptic responders (N=42) and one of nonresponders (N=64). A group of healthy volunteers screened for major psychiatric disorders was also included (N=89). In addition, age at onset of psychotic symptoms, attention performance and family loading for schizophrenia spectrum disorders were compared between patients with different genotypes in the DRD3 and DAT1 genes. RESULTS:No significant differences in the allelic distribution of the DRD3 and DAT1 polymorphisms were detected between schizophrenic patients and controls. A trend toward an excess of DRD3 genotype Gly/Gly was observed in neuroleptic nonresponder schizophrenic patients compared to controls (chi(2)=3. 30, df=1, p=0.07). No significant differences in age at onset of psychotic symptoms, attention task performance or family loading for schizophrenia spectrum disorders were observed between groups with different DRD3 and DAT1 genotypes. CONCLUSION:These results do not support the role of either of these genes in increasing susceptibility to schizophrenia or in modulating its phenotype in the studied population.
journal_name
J Psychiatr Resjournal_title
Journal of psychiatric researchauthors
Joober R,Toulouse A,Benkelfat C,Lal S,Bloom D,Labelle A,Lalonde P,Turecki G,Rouleau GAdoi
10.1016/s0022-3956(00)00018-2subject
Has Abstractpub_date
2000-07-01 00:00:00pages
285-91issue
4-5eissn
0022-3956issn
1879-1379pii
S0022-3956(00)00018-2journal_volume
34pub_type
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